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PEG-Bottlebrush Stabilizer-Based Worm-like Nanocrystal Micelles with Long-Circulating and Controlled Release for Delivery of a BCR-ABL Inhibitor against Chronic Myeloid Leukemia (CML)
期刊论文
PHARMACEUTICS, 2022, 卷号: 14
作者:
Liang, Huamin
;
Zou, Fengming
;
Fu, Liyi
;
Liu, Qingwang
;
Wang, Beilei
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/12/23
drug nanocrystal
stabilizer
micelle
BCR-ABL
chronic myeloid leukemia (CML)
Exploring cell-specific miRNA regulation with single-cell miRNA-mRNA co-sequencing data
期刊论文
BMC BIOINFORMATICS, 2021, 卷号: 22
作者:
Zhang, Junpeng
;
Liu, Lin
;
Xu, Taosheng
;
Zhang, Wu
;
Zhao, Chunwen
收藏
  |  
浏览/下载:149/0
  |  
提交时间:2022/01/10
miRNA
mRNA
Single-cell miRNA-mRNA co-sequencing
Pseudo-cell interpolation
Cell-specific miRNA regulation
Single-cell clustering analysis
Cell-cell crosstalk
Chronic myelogenous leukemia
Discovery and structure - activity relationship exploration of pyrazolo [1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 48, 页码: 13
作者:
Chen, Yun
;
Bai, Gang
;
Li, Yan
;
Ning, Yi
;
Cao, Sufen
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2021/12/01
FLT3
FLT3-ITD
Acute myeloid leukemia
Structure-activity relationships
Pyrazolo[1, 5-a]pyrimidine
Discovery of a highly potent kinase inhibitor capable of overcoming multiple imatinib-resistant ABL mutants for chronic myeloid leukemia (CML)
期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2021, 卷号: 897
作者:
Lu, Tingting
;
Cao, Jiangyan
;
Zou, Fengming
;
Li, Xixiang
;
Wang, Aoli
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2021/04/26
BCR-ABL
ABL mutants
Chronic myeloid leukemia
Kinase inhibitor
Imatinib resistance
Adverse events associated with nilotinib in chronic myeloid leukemia: mechanisms and management strategies
期刊论文
EXPERT REVIEW OF CLINICAL PHARMACOLOGY, 2021
作者:
Wang, Zeng
;
Jiang, Liyu
;
Yan, Hao
;
Xu, Zhifei
;
Luo, Peihua
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/04/26
Adverse events
chronic myeloid leukemia
management
mechanisms
molecular target
nilotinib
Advances of Nanoparticles for Leukemia Treatment
期刊论文
ACS BIOMATERIALS SCIENCE & ENGINEERING, 2020, 卷号: 6, 期号: 12, 页码: 6478-6489
作者:
Shen, Jie
;
Lu, Zhiguo
;
Wang, Jianze
;
Zhang, Tianlu
;
Yang, Jun
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2021/03/29
Leukemia
Nanoparticles
Delivery
Drugs
Microenvironment
Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 22, 页码: 7
作者:
Bi, Xiaoyang
;
Chen, Yu
;
Sun, Zhongya
;
Lu, Wenchao
;
Xu, Pan
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/05/24
Drug design
CBP
Bromodomain
Inhibitor
Acute myeloid leukemia
An ultra-long circulating nanoparticle for reviving a highly selective BCR-ABL inhibitor in long-term effective and safe treatment of chronic myeloid leukemia
期刊论文
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2020, 卷号: 29
作者:
Fu, Liyi
;
Zou, Fengming
;
Liu, Qingwang
;
Wang, Beilei
;
Wang, Junqing
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/11/30
Chronic myeloid leukemia
BCR-ABL
Long-circulating nanoparticle
Drug delivery
Design, synthesis, and biological evaluation of tetrahydroquinolin derivatives as potent inhibitors of CBP bromodomain
期刊论文
BIOORGANIC CHEMISTRY, 2020, 卷号: 101, 页码: 11
作者:
Chen, Yu
;
Bi, Xiaoyang
;
Zhang, Fengcai
;
Sun, Zhongya
;
Xu, Pan
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/12/24
In silico screening
Drug design
CBP
Bromodomain
Inhibitor
Acute Myeloblastic Leukemia
Network-based analysis with primary cells reveals drug response landscape of acute myeloid leukemia
期刊论文
EXPERIMENTAL CELL RESEARCH, 2020, 卷号: 393
作者:
Chen, Cheng
;
Wang, Li
;
Li, Lili
;
Wang, Aoli
;
Huang, Tao
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/11/26
Acute myeloid leukemia (AML)
Drug response
Gene mutations
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