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CORC

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Intracellular Delivery of Micron-Sized Magnetic Particles through a Virus Infection Pathway 期刊论文
ACS APPLIED MATERIALS & INTERFACES, 2022
作者:  Feng, Xiayi;  Gao, Ding;  Jing, Yipeng;  Qian, Junchao;  Cui, Zongqiang
收藏  |  浏览/下载：14/0  |  提交时间：2022/12/22
The cyclase-associated protein ChCAP is important for regulation of hyphal growth, appressorial development, penetration, pathogenicity, conidiation, intracellular cAMP level, and stress tolerance in Colletotrichum higginsianum 期刊论文
Plant Science, 2019, 卷号: Vol.283, 页码: 1-10
作者:  Wenjun Zhu;  Xiaowen Xu;  Fang Peng;  Da-zhong Yan;  Shaopeng Zhang
收藏  |  浏览/下载：10/0  |  提交时间：2019/12/17
The cyclase-associated protein ChCAP is important for regulation of hyphal growth, appressorial development, penetration, pathogenicity, conidiation, intracellular cAMP level, and stress tolerance in Colletotrichum higginsianum. 期刊论文
Plant science : an international journal of experimental plant biology, 2019, 卷号: 283, 页码: 1-10
作者:  Zhu, Wenjun;  Xu, Xiaowen;  Peng, Fang;  Yan, Da-zhong;  Zhang, Shaopeng
收藏  |  浏览/下载：9/0  |  提交时间：2019/12/27
Posttranslational Modification Control of Inflammatory Signaling 期刊论文
REGULATION OF INFLAMMATORY SIGNALING IN HEALTH AND DISEASE, 2017, 卷号: 1024
作者:  Si, Yibo;  Zhang, Yunlu;  Chen, Zijuan;  Zhou, Ruixue;  Zhang, Yihua
收藏  |  浏览/下载：8/0  |  提交时间：2019/12/05
p38 inhibition provides anti-DNA virus immunity by regulation of USP21 phosphorylation and STING activation 期刊论文
JOURNAL OF EXPERIMENTAL MEDICINE, 2017
Chen, Yunfei; Wang, Lufan; Jin, Jiali; Luan, Yi; Chen, Cong; Li, Yu; Chu, Hongshang; Wang, Xinbo; Liao, Guanghong; Yu, Yue; Teng, Hongqi; Wang, Yanming; Pan, Weijuan; Fang, Lan; Liao, Lujian; Jiang, Zhengfan; Ge, Xin; Li, Bin; Wang, Ping
收藏  |  浏览/下载：8/0  |  提交时间：2017/12/03
Transcriptome analysis reveals global regulation in response to CO2 supplementation in oleaginous microalga Coccomyxa subellipsoidea C-169 期刊论文
BIOTECHNOLOGY FOR BIOFUELS, 2016
Peng, Huifeng; Wei, Dong; Chen, Gu; Chen, Feng
收藏  |  浏览/下载：115/0  |  提交时间：2017/12/04
DMS triggers apoptosis associated with the inhibition of SPHK1/NF-kappa B activation and increase in intracellular Ca2+ concentration in human cancer cells 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2014, 卷号: 33, 期号: [db:dc_citation_issue], 页码: 17-24
作者:  Chen, Kan;  Pan, Qiuwei;  Gao, Ying;  Yang, Xinyan;  Wang, Shibing
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/03
Elucidating the role of free polycationic chains in polycation gene carriers by free chains of polyethylenimine or N,N,N-trimethyl chitosan plus a certain polyplex 期刊论文
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2014, 卷号: 9
作者:  Xu, Tao;  Liu, Wei;  Wang, Suhang;  Shao, Zhengzhong
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/19
Delivery system for DNAzymes using arginine-modified hydroxyapatite nanoparticles for therapeutic application in a nasopharyngeal carcinoma model 期刊论文
International Journal of Nanomedicine, 2013, 卷号: 8, 期号: 1, 页码: 3107-3118
作者:  Chen, Yan;  Yang, Lifang*;  Huang, Suping;  Li, Zhi;  Zhang, Lu
收藏  |  浏览/下载：8/0  |  提交时间：2019/12/03
DNAzymes are synthetic  single-stranded  catalytic nucleic acids that bind and cleave target mRNA in a sequence-specific manner  and have been explored for genotherapeutics. One bottleneck restricting their application is the lack of an efficient delivery system. As an inorganic nanomaterial with potentially wide application  nanohydroxyapatite particles (nHAP) have attracted increasing attention as new candidates for nonviral vectors. In this study  we developed an nHAP-based delivery system and explored its cellular uptake mechanisms  intracellular localization  and biological effects. Absorption of arginine-modified nanohydroxyapatite particles (Arg-nHAP) and DZ1 (latent membrane protein 1 [LMP1]-targeted) reached nearly 100% efficiency under in vitro conditions. Using specific inhibitors  cellular uptake of the Arg-nHAP/DZ1 complex was shown to be mediated by the energy-dependent endocytosis pathway. Further  effective intracellular delivery and nuclear localization of the complex was confirmed by confocal microscopy. Biologically  the complex successfully downregulated the expression of LMP1 in nasopharyngeal carcinoma cells. In a mouse tumor xenograft model  the complex was shown to be delivered efficiently to tumor tissue  downregulating expression of LMP1 and suppressing tumor growth. These results suggest that Arg-nHAP may be an efficient vector for nucleic acid-based drugs with potential clinical application.  
Potential protection of green tea polyphenols against intracellular amyloid beta-induced toxicity on primary cultured prefrontal cortical neurons of rats 期刊论文
神经科学快报, 2012
Qin, Xiao-Yan; Cheng, Yong; Yu, Long-Chuan
收藏  |  浏览/下载：3/0  |  提交时间：2015/11/12

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