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上海药物研究所 [6]
清华大学 [2]
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大连理工大学 [2]
大连化学物理研究所 [2]
武汉大学 [2]
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期刊论文 [24]
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2019 [1]
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Conserved Residues Control the T1R3-Specific Allosteric Signaling Pathway of the Mammalian Sweet-Taste Receptor
期刊论文
CHEMICAL SENSES, 2019, 卷号: 44, 期号: 5
作者:
Cheron, Jean-Baptiste
;
Soohoo, Amanda
;
Wang, Yi
;
Golebiowski, Jerome
;
Antonczak, Serge
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/05
allosteric binding site
class C GPCR
cyclamate
mammalian
sweet-taste receptor
taste modulator
Crystal structures of sirt3 reveal that the alpha 2-alpha 3 loop and alpha 3-helix affect the interaction with long-chain acyl lysine
期刊论文
Febs letters, 2016, 卷号: 590, 期号: 17, 页码: 3019-3028
作者:
Gai, Wei
;
Li, He
;
Jiang, Hualiang
;
Long, Yaqiu
;
Liu, Dongxiang
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2019/05/09
Allosteric site
Deacylation
Inhibitor
Long-chain fatty acid
Sirtuins
Crystal structures of SIRT3 reveal that the alpha 2-alpha 3 loop and alpha 3-helix affect the interaction with long-chain acyl lysine
期刊论文
FEBS LETTERS, 2016, 卷号: 590, 期号: 17, 页码: 3019-3028
作者:
Gai, Wei
;
Li, He
;
Jiang, Hualiang
;
Long, Yaqiu
;
Liu, Dongxiang
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
allosteric site
deacylation
inhibitor
long-chain fatty acid
sirtuins
Structure-based optimization and derivatization of 2-substituted quinolone-based non-nucleoside HCV NS5B inhibitors with submicromolar cellular replicon potency
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 期号: 12, 页码: 2900-2906
作者:
Cheng, Yu
;
Shen, Jian
;
Peng, Run-Ze
;
Wang, Gui-Feng
;
Zuo, Jian-Ping
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
HCV NS5B polymerase
2-Alkyl quinolone
1,6-Naphthyridine-4,5-dione
Non-nucleoside inhibitor
Direct acting antiviral
Allosteric site
New insight into the binding modes of TNP-AMP to human liver fructose-1,6-bisphosphatase
期刊论文
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2016, 卷号: 165, 页码: 155-160
作者:
Han, Xinya
;
Huang, Yunyuan
;
Zhang, Rui
;
Xiao, San
;
Zhu, Shuaihuan
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/23
FBPase
fructose-1,6-bisphosphatase
TNP-AMP
2′,3′-O-(2,4,6-trinitrophenyl)adenosine 5′-monophosphate
FBP
fructose 1,6-bisphosphate
AMP
adenosine monophosphate
FDP
fructose-2,6-bisphosphate
F6P
fructose 6-phosphate
Fructose-1,6-bisphosphatase
TNP-AMP binding site
Active site
Allosteric site
Inhibitor binding site
New insight into the binding modes of TNP-AMP to human liver fructose-1,6-bisphosphatase
期刊论文
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2016, 卷号: 165
作者:
Han, Xinya
;
Huang, Yunyuan
;
Zhang, Rui
;
Xiao, San
;
Zhu, Shuaihuan
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/05
Fructose-1,6-bisphosphatase
TNP-AMP binding site
Active site
Allosteric site
Inhibitor binding site
Computer-Aided Drug Discovery and Design Targeting Ion Channels
期刊论文
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2016, 卷号: 16, 期号: 16, 页码: 1819-1829
作者:
Zhang, Qiansen
;
Gao, Zhaobing
;
Yang, Huaiyu
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/01/08
Ion channel
Drug design
Drug discovery
Molecular dynamic simulation
Allosteric site
Allosteric sites can be identified based on the residue-residue interaction energy difference
期刊论文
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2015, 卷号: 83, 期号: 8, 页码: 1375-1384
作者:
Ma, Xiaomin
;
Qi, Yifei
;
Lai, Luhua
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2015/10/27
allosteric site identification
MM
GBSA
energy decomposition
residue-residue interaction energy
CAVITY
Ainsliadimer A selectively inhibits IKK alpha/beta by covalently binding a conserved cysteine
期刊论文
NATURE COMMUNICATIONS, 2015
Dong, Ting
;
Li, Chao
;
Wang, Xing
;
Dian, Longyang
;
Zhang, Xiuguo
;
Li, Lin
;
Chen, She
;
Cao, Ran
;
Li, Li
;
Huang, Niu
;
He, Sudan
;
Lei, Xiaoguang
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2017/12/03
NF-KAPPA-B
BIOMIMETIC SYNTHESES
ALLOSTERIC SITE
CANCER-THERAPY
BCL-X
ACTIVATION
PHOSPHORYLATION
INFLAMMATION
KINASE
UBIQUITINATION
Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human alpha 7 Nicotinic Receptor
期刊论文
PLOS ONE, 2015, 卷号: 10, 期号: 9, 页码: -
作者:
Zhang, Qinhui
;
Du, Yingjie
;
Zhang, Jianliang
;
Xu, Xiaojun
;
Xue, Fenqin
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2016/12/22
CHOLINERGIC ANTIINFLAMMATORY PATHWAY
POSITIVE ALLOSTERIC MODULATION
GATED ION-CHANNEL
ACETYLCHOLINE-RECEPTOR
AGONIST-BINDING
INTERNATIONAL UNION
TRANSMEMBRANE SITE
SILENT AGONIST
AMINO-ACIDS
ACTIVATION
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