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Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439
期刊论文
ACS INFECTIOUS DISEASES, 2021, 卷号: 7, 期号: 7, 页码: 1885-1893
作者:
Shackleford, David M.
;
Chiu, Francis C. K.
;
Katneni, Kasiram
;
Blundell, Scott
;
McLaren, Jenna
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2021/11/04
OZ439 (artefenomel)
malaria
metabolite identification
cytochrome P450 metabolism
cytochrome P450 inhibition
time-dependent inhibition
In Vivo Efficacy and Metabolism of the Antimalarial Cycleanine and Improved In Vitro Antiplasmodial Activity of Semisynthetic Analogues
期刊论文
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021, 卷号: 65, 期号: 2, 页码: 11
作者:
Uche, Fidelia Ijeoma
;
Guo, Xiaozhen
;
Okokon, Jude
;
Ullah, Imran
;
Horrocks, Paul
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/05/24
malaria
Plasmodium falciparum
Plasmodium berghei
bisbenzylisoquinoline alkaloids
cycleanine
metabolism
in vivo activity
antimalarial agents
drug metabolism
Resistance to Some But Not Other Dimeric Lindenane Sesquiterpenoid Esters Is Mediated by Mutations in a Plasmodium falciparum Esterase
期刊论文
ACS INFECTIOUS DISEASES, 2020, 卷号: 6, 期号: 11, 页码: 2994-3003
作者:
Butler, Joshua H.
;
Baptista, Rodrigo P.
;
Valenciano, Ana L.
;
Zhou, Bin
;
Kissinger, Jessica C.
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2021/05/24
Plasmodium
PfPARE
structure-resistance relationship study
Malaria Box
Pathogen Box
lindenane sesquiterpenoid dimers
Discovery of 6 '-chloro-N-methyl-5 '-(phenylsulfonamido)-[3,3 '-bipyridine]-5-carboxamide (CHMFL-PI4K-127) as a novel Plasmodium falciparum PI(4)K inhibitor with potent antimalarial activity against both blood and liver stages of Plasmodium
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 188
作者:
Liang, Xiaofei
;
Jiang, Zongru
;
Huang, Zhenghui
;
Li, Feng
;
Chen, Cheng
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/11/26
PI4K kinase
Kinase inhibitor
Malaria
Blood stage
Liver stage
Identification and analysis of vulnerable populations for malaria based on K-prototypes clustering
期刊论文
ENVIRONMENTAL RESEARCH, 2019, 卷号: 176
作者:
Li, Chenlu
;
Wu, Xiaoxu
;
Cheng, Xiao
;
Fan, Cheng
;
Li, Zhixin
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2019/09/24
Malaria
K-prototypes clustering
Vulnerable populations
Yunnan
Nano-biotechnology: a new approach to treat and prevent malaria
期刊论文
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2019, 卷号: 14, 页码: 1401-1410
作者:
Rahman, Khaista
;
Khan, Shahid Ullah
;
Fahad, Shah
;
Chang, Ming Xian
;
Abbas, Aqleem
收藏
  |  
浏览/下载:78/0
  |  
提交时间:2019/06/18
malaria
vectors
chemotherapy
drug resistance
nano-biotechnology
The glucose-6-phosphate dehydrogenase Mahidol variant protects against uncomplicated Plasmodium vivax infection and reduces disease severity in a Kachin population from northeast Myanmar.
期刊论文
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2019, 卷号: 75
作者:
Yi Haoan
;
Li Hong
;
Liang Luxin
;
Wu Yanrui
;
Zhang Lu
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/12/04
G6PD
Haplotype 1311T/93C
Kachin population
Mahidol variant
Malaria
Plasmodium vivax
Geographical heterogeneity in prevalence of subclinical malaria infections at sentinel endemic sites of Myanmar
期刊论文
PARASITES & VECTORS, 2019, 卷号: 12
作者:
Liu, Ziling
;
Soe, Than Naing
;
Zhao, Yan
;
Than, Aye
;
Cho, Cho
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2019/12/04
Myanmar
Malaria
Prevalence
Subclinical
Pooling strategy
Changing epidemiology and challenges of malaria in China towards elimination
期刊论文
MALARIA JOURNAL, 2019, 卷号: 18
作者:
Lai, Shengjie
;
Sun, Junling
;
Ruktanonchai, Nick W.
;
Zhou, Sheng
;
Yu, Jianxing
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/12/05
Malaria
Epidemiology
Elimination
Importation
China
Africa
Southeast Asia
Numerical design of a microfluidic chip for probing mechanical properties of cells
期刊论文
Journal of Biomechanics, 2019, 卷号: Vol.84, 页码: 103-112
作者:
Ting Ye
;
Huixin Shi
;
Nhan Phan-Thien
;
Chwee Teck Lim
;
Yu Li
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/17
Smoothed
dissipative
particle
dynamics
Immersed
boundary
method
Mechanical
properties
Microfluidic
chip
Red
blood
cell
Malaria
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