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Synthesis and biological evaluation of benzomorpholine derivatives as novel EZH2 inhibitors for anti-non-small cell lung cancer activity. 期刊论文
Molecular diversity, 2019
作者:  Feng Qiang;  He Hualong;  Gao Tiantao;  Zhang Qiangsheng;  Liu Zhihao
收藏  |  浏览/下载：77/0  |  提交时间：2019/02/25
In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 卷号: 115, 期号: 17, 页码: E3978-E3986
作者:  Wu, Qibiao;  Tian, Yahui;  Zhang, Jian;  Tong, Xinyuan;  Huang, Hsinyi
收藏  |  浏览/下载：68/0  |  提交时间：2018/10/10
In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 卷号: 115, 期号: 17
作者:  Wu, Qibiao;  Tian, Yahui;  Zhang, Jian;  Tong, Xinyuan;  Huang, Hsinyi
收藏  |  浏览/下载：18/0  |  提交时间：2019/12/05
Combination of EZH2 inhibitor and BET inhibitor for treatment of diffuse intrinsic pontine glioma 期刊论文
CELL AND BIOSCIENCE, 2017, 卷号: 7
作者:  Zhang, Yaqin[1];  Dong, Weijie[2];  Zhu, Junying[3];  Wang, Lizhu[1];  Wu, Xinjian[2]
收藏  |  浏览/下载：7/0  |  提交时间：2019/04/24
Inhibitory effect of EZH2 inhibitor on cervical cancer HeLa cells 期刊论文
Journal of Xi'an Jiaotong University (Medical Sciences), 2015, 卷号: 36, 期号: [db:dc_citation_issue]
作者:  Ding, Mu-Yang;  Jiang, Wen-Jun;  Zhang, Li;  Cui, Yu-Meng;  Zhang, Hang
收藏  |  浏览/下载：2/0  |  提交时间：2019/12/02
ABCB1 and ABCG2 restrict the brain penetration of a panel of novel EZH2-Inhibitors 期刊论文
INTERNATIONAL JOURNAL OF CANCER, 2015, 卷号: 137, 期号: 8, 页码: 2007-2018
作者:  Zhang, Ping;  de Gooijer, Mark C.;  Buil, Levi C. M.;  Beijnen, Jos H.;  Li, Gang
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/17
EZH2: biology, disease, and structure-based drug discovery 期刊论文
ACTA PHARMACOLOGICA SINICA, 2014, 卷号: 35, 期号: 2, 页码: 161-174
作者:  Tan, Jin-zhi;  Yan, Yan;  Wang, Xiao-xi;  Jiang, Yi;  Xu, H. Eric
收藏  |  浏览/下载：13/0  |  提交时间：2019/01/08
Epigenetic targets and drug discovery: Part 1: Histone methylation 期刊论文
Pharmacology and Therapeutics, 2014, 卷号: 143, 期号: 3, 页码: 275-294
作者:  Liu, Yanli;  Liu, Ke;  Qin, Su;  Xu, Chao;  Min, Jinrong*
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/23
Epigenetics  Histone methylation  Inhibitor  Chemical probe  Cancer  PTM  posttranslational modification  HMTs  histone methyltrans-ferases  SET  Suv39, E(z) and Trithorax  SUV39  Su(var)3-9  SUV420  histone-lysine N-methyltransferase SUV420  G9a  euchromatic histone-lysine N-methyltransferase 2  GLP  G9a-like protein 1  Wiz  widely-interspaced zinc finger-containing protein  CDYL1  chromodomain Y-like protein  ACIN1  apoptotic chromatin condensation inducer in the nucleus  SAH  S-adenosyl-l-homocysteine  l  SAM  S-adenosylmethionine  Dot1  disruptor of telomeric silencing  Dot1L  DOT1-Like protein  EZH1  Enhancer of zeste homolog 1  EZH2  Enhancer of zeste homolog 2  Hox  homeotic box  PcG  Polycomb group  PRC1  Polycomb Repressive Complex 1  PRC2  Polycomb Repressive Complex 2  DZNep  3-Deazan- eplanocin A  SMYD2  SET and MYND domain-containing protein 2  PRMT  protein arginine methyltransferases  AMI-1  arginine methyltransferase inhibitor-1  MBT  Malignant Brain Tumor  PEV  position-effect variegation  HSPC  hematopoietic stem and progenitor cells  ChIP  chromatin immunoprecipitation  PK  pharmacokinetic  
ezh2biologydiseaseandstructurebaseddrugdiscovery 期刊论文
actapharmacologicasinica, 2014, 卷号: 35, 期号: 2, 页码: 161
作者:  Tan Jinzhi;  Yan Yan;  Wang Xiaoxi;  Jiang Yi;  Xu H Eric
收藏  |  浏览/下载：3/0  |  提交时间：2020/07/01
Synthesis and biological evaluation of benzomorpholine derivatives as novel EZH2 inhibitors for anti-non-small cell lung cancer activity 期刊论文
Molecular Diversity, 页码: 1-16
作者:  Qiang Feng;  Hualong He;  Tiantao Gao;  Qiangsheng Zhang;  Zhihao Liu
收藏  |  浏览/下载：3/0  |  提交时间：2019/02/25

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