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Novel selective kappa agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Wei, Yuan-yuan
;
Ma, Yan
;
Yao, Song-yu
;
Kong, Ling-hui
;
Liu, Xiao
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2021/11/04
kappa-opioid receptor agonist
4,5-expoxymorphinan
antinociception
conditioned place aversion
sedation
U50,488H
morphine
Nor-BNI
beta-FNA
Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxypheny1)-N-phenylpiperidine-1-carboxamide as novel potent analgesic
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 189, 页码: 14
作者:
Huang, Huoming
;
Wang, Wenli
;
Xu, Xuejun
;
Zhu, Chen
;
Wang, Yujun
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/07/01
Selective MOR agonists
Antinociception
Analgesic
Opioids
Molecular mechanism
Galanin plays a role in antinociception via binding to galanin receptors in the nucleus accumbens of rats with neuropathic pain
期刊论文
NEUROSCIENCE LETTERS, 2019, 卷号: 706
作者:
Gao, Yi
;
Li, Chong-Yang
;
Dong, Wei
;
Zhang, Ying
;
Liu, Ya-Nan
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/12/04
Galanin
Galanin receptors
Antinociception
Neuropathic pain
Nucleus accumbens
Galanin Receptor 1 Plays an Antinociceptive Effect via Inhibiting PKA Activation in the Nucleus Accumbens of Rats With Neuropathic Pain
期刊论文
PHYSIOLOGICAL RESEARCH, 2019, 卷号: 68, 期号: 3
作者:
Liu, Ya-Nan
;
Zhang, Ying
;
Gao, Yi
;
Li, Chong-Yang
;
Dong, Wei
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/12/04
Antinociception
Galanin receptor 1
Protein kinase A
Neuropathic pain
Nucleus accumbens
Cannabinoids-induced peripheral analgesia depends on activation of BK channels.
期刊论文
Brain research, 2019
作者:
Li Yongfeng
;
Zhang Leili
;
Wu Yuwei
;
Zheng Qiaohua
;
Chen Mengjiao
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/12/13
Antinociception
BK
channel
Cannabinoids
Neuropathic
pain
Sciatic
nerve
Cannabinoids-induced peripheral analgesia depends on activation of BK channels
期刊论文
Brain Research, 2019, 卷号: Vol.1711, 页码: 23-28
作者:
Yongfeng Li
;
Leili Zhang
;
Yuwei Wu
;
Qiaohua Zheng
;
Mengjiao Chen
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/12/13
Sciatic
nerve
Cannabinoids
BK
channel
Neuropathic
pain
Antinociception
Endomorphin-1 analogs with oligoarginine-conjugation at C-terminus produce potent antinociception with reduced opioid tolerance in paw withdrawal test
期刊论文
2018, 卷号: 106, 页码: 96-101
作者:
Yuan, Bi-yu
;
Liu, Wei-zhe
;
Wang, Xiao-fang
;
Zhang, Yu-zhe
;
Yang, Dai-jun
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/01/03
EM-1 analogs
Oligoarginine-conjugation
Antinociception
BBB
Opioid tolerance
Endomorphins: Promising Endogenous Opioid Peptides for the Development of Novel Analgesics.
期刊论文
Neuro-Signals, 2017, 卷号: 25, 期号: 1
作者:
Gu Zheng-Hui
;
Wang Bo
;
Kou Zhen-Zhen
;
Bai Yang
;
Chen Tao
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/05
Antinociception
Clinical implications
Coexistence
Distribution
Endomorphins
Modification
Neural circuitry
Ultrastructure
Involvement of galanin and galanin receptor 2 in nociceptive modulation in anterior cingulate cortex of normal rats and rats with mononeuropathy
期刊论文
SCIENTIFIC REPORTS, 2017
Zhang, Meng-Lin
;
Wang, Hong-Bo
;
Fu, Feng-Hua
;
Yu, Long-Chuan
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2017/12/03
CENTRAL-NERVOUS-SYSTEM
PAIN-RELATED AVERSION
NEUROPATHIC PAIN
PERIAQUEDUCTAL GREY
INDUCED ANTINOCICEPTION
SYNAPTIC PLASTICITY
NUCLEUS-ACCUMBENS
ARCUATE NUCLEUS
ACTIVATION
BEHAVIOR
Antinociception induced by galanin in anterior cingulate cortex in rats with acute inflammation
期刊论文
NEUROSCIENCE LETTERS, 2017
Zhang, Meng-Lin
;
Fu, Feng-Hua
;
Yu, Long-Chuan
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2017/12/03
Anterior cingulate cortex (ACC)
Antinociception
Galanin
Galanin receptor 2 (Gal R2)
Hindpaw withdrawal latency
Acute inflammation
CENTRAL-NERVOUS-SYSTEM
PERIAQUEDUCTAL GREY
NUCLEUS-ACCUMBENS
NEUROPATHIC PAIN
ARCUATE NUCLEUS
MONONEUROPATHY
INVOLVEMENT
HYPOTHALAMUS
RECEPTORS
PEPTIDE
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