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复旦大学上海医学院 [11]
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期刊论文 [48]
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Automated design and optimization of multitarget schizophrenia drug candidates by deep learning
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 204, 页码: 16
作者:
Tan, Xiaoqin
;
Jiang, Xiangrui
;
He, Yang
;
Zhong, Feisheng
;
Li, Xutong
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/12/21
Schizophrenia
Multitarget antipsychotic drugs
Recurrent neural network
Multitask deep neural network
Automated drug design
Deep Learning Enhancing Kinome-Wide Polypharmacology Profiling: Model Construction and Experiment Validation
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 16, 页码: 8723-8737
作者:
Li, Xutong
;
Li, Zhaojun
;
Wu, Xiaolong
;
Xiong, Zhaoping
;
Yang, Tianbiao
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/12/21
Deep Learning Enhancing Kinome-Wide Polypharmacology Profiling: Model Construction and Experiment Validation
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 16, 页码: 8723-8737
作者:
Li, Xutong
;
Li, Zhaojun
;
Wu, Xiaolong
;
Xiong, Zhaoping
;
Yang, Tianbiao
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/12/21
TransformerCPI: improving compound-protein interaction prediction by sequence-based deep learning with self-attention mechanism and label reversal experiments
期刊论文
BIOINFORMATICS, 2020, 卷号: 36, 期号: 16, 页码: 4406-4414
作者:
Chen, Lifan
;
Tan, Xiaoqin
;
Wang, Dingyan
;
Zhong, Feisheng
;
Liu, Xiaohong
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2021/05/24
KinomeX: a web application for predicting kinome-wide polypharmacology effect of small molecules
期刊论文
BIOINFORMATICS, 2019, 卷号: 35, 期号: 24, 页码: 5354-5356
作者:
Li, Zhaojun
;
Li, Xutong
;
Liu, Xiaohong
;
Fu, Zunyun
;
Xiong, Zhaoping
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  |  
浏览/下载:79/0
  |  
提交时间:2020/07/01
Decentralized wastewater treatment in an urban setting: a pilot study of the circulating fluidized bed bioreactor treating septic tank effluent
期刊论文
ENVIRONMENTAL TECHNOLOGY, 2019, 页码: 11
作者:
Liu, Anqi
;
Nelson, Michael J.
;
Wang, Xiaobo
;
Li, Haibin
;
He, Xiaoqin
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/10/29
Biological nutrient removal
attached growth process
high-efficiency process
decentralized treatment
in-situ treatment
Combined Visualization of Nigrosome-1 and Neuromelanin in the Substantia Nigra Using 3T MRI for the Differential Diagnosis of Essential Tremor and de novo Parkinson's Disease
期刊论文
FRONTIERS IN NEUROLOGY, 2019, 卷号: 10
作者:
Zeng, Mengsu
;
Zhong, Chunjiu
;
Lv, Minzhi
;
Li, Yuanfang
;
Huang, Zhen
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  |  
浏览/下载:83/0
  |  
提交时间:2019/12/05
Parkinson's disease
essential tremor
neuromelanin
nigrosome-1
QSM
substantia nigra
Implications of Successful Symptomatic Treatment in Parkinson's Disease for Therapeutic Strategies of Alzheimer's Disease
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2019, 卷号: 10, 期号: 2
作者:
Zhao, Lei
;
Cheng, Xiaoqin
;
Zhong, Chunjiu
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/05
Alzheimer's disease
Parkinson's disease
symptomatic treatment
brain glucose hypometabolism
brain cholinergic dysfunction
therapeutic strategies
Neuromelanin-sensitive MRI of the substantia nigra: An imaging biomarker to differentiate essential tremor from tremor-dominant Parkinson's disease
期刊论文
PARKINSONISM & RELATED DISORDERS, 2019, 卷号: 58
作者:
Wang, Jian
;
Huang, Zhen
;
Li, Yuanfang
;
Ye, Fang
;
Wang, Changpeng
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2019/12/05
Parkinson's disease
Essential tremor
Neuromelanin
Magnetic resonance imaging
Diagnostic test
Mild cognitive impairment in de novo Parkinson's disease: A neuromelanin MRI study in locus coeruleus
期刊论文
MOVEMENT DISORDERS, 2019, 卷号: 34, 期号: 6
作者:
Li, Yuanfang
;
Wang, Changpeng
;
Wang, Jian
;
Zhou, Ying
;
Ye, Fang
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2019/12/05
Parkinson's disease
neuromelanin
MRI
mild cognitive impairment
locus coeruleus
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