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科研机构
新疆理化技术研究所 [6]
上海大学 [6]
地球环境研究所 [6]
河北大学 [3]
安徽大学 [2]
湖南大学 [1]
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期刊论文 [21]
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A deep learning method for repurposing antiviral drugs against new viruses via multi-view nonnegative matrix factorization and its application to SARS-CoV-2
期刊论文
BRIEFINGS IN BIOINFORMATICS, 2022, 卷号: 23, 期号: 1, 页码: 1-16
作者:
Su, XR (Su, Xiaorui) [1]
;
Hu, L (Hu, Lun) [1]
;
You, ZH (You, Zhuhong) [2]
;
Hu, PW (Hu, Pengwei) [1]
;
Wang, L (Wang, Lei) [3]
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2022/05/06
SARS-CoV-2
drugrepositioning
constrained multi-view nonnegative matrix factorization
deeplearning
graphconvolutionalnetwork
HINGRL: predicting drug-disease associations with graph representation learning on heterogeneous information networks
期刊论文
BRIEFINGS IN BIOINFORMATICS, 2022, 卷号: 23, 期号: 1, 页码: 1-15
作者:
Zhao, BW (Zhao, Bo-Wei) [1] , [2]
;
Hu, L (Hu, Lun) [2]
;
You, ZH (You, Zhu-Hong) [3] , [4]
;
Wang, L (Wang, Lei) [5]
;
Su, XR (Su, Xiao-Rui) [1] , [2]
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2022/05/06
drug-disease associations
prediction
heterogeneous information network
graph representation learning
drug repositioning
An Efficient Computational Model for Large-Scale Prediction of Protein-Protein Interactions Based on Accurate and Scalable Graph Embedding
期刊论文
FRONTIERS IN GENETICS, 2021, 卷号: 12, 期号: 2, 页码: 1-10
作者:
Su, XR (Su, Xiao-Rui)[ 1,2,3 ]
;
You, ZH (You, Zhu-Hong)[ 1,2,3 ]
;
Hu, L (Hu, Lun)[ 1,2,3 ]
;
Huang, YA (Huang, Yu-An)[ 1 ]
;
Wang, Y (Wang, Yi)[ 1,2,3 ]
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2021/05/24
large-scale
protein-protein interaction
GraphZoom
weighted graph
graph embedding
In silico drug repositioning using deep learning and comprehensive similarity measures
期刊论文
BMC BIOINFORMATICS, 2021, 卷号: 22, 期号: 增刊3, 页码: 1-14
作者:
Yi, HC (Yi, Hai-Cheng) 1 , 2
;
You, ZH (You, Zhu-Hong) 1
;
Wang, L (Wang, Lei) 1
;
Su, XR (Su, Xiao-Rui) 1 , 2
;
Zhou, X (Zhou, Xi) 1
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2021/07/14
Drug repositioningDrug-disease interactionGated recurrent unitsGaussian interaction profile kernelMachine learning
Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:
Wang, Z (Wang, Zhen)[ 1 ]
;
Jiang, XR (Jiang, Xiangrui)[ 1 ]
;
Zhang, XL (Zhang, Xianglei)[ 1,2 ]
;
Tian, GH (Tian, Guanghui)[ 3 ]
;
Yang, RL (Yang, Rulei)[ 3 ]
收藏
  |  
浏览/下载:137/0
  |  
提交时间:2019/06/28
Synthesis and biological investigation of tetrahydropyridopyrimidinone derivatives as potential multireceptor atypical antipsychotics
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 卷号: 25, 期号: 17, 页码: 4904-4916
作者:
Xiamuxi, H (Xiamuxi, Hainimu)
;
Wang, Z (Wang, Zhen)
;
Li, JF (Li, Jianfeng)
;
Wang, Y (Wang, Yu)
;
Wu, CH (Wu, Chunhui)
收藏
  |  
浏览/下载:112/0
  |  
提交时间:2017/10/31
Dopamine
Serotonin
Multireceptor
Atypical Antipsychotic
5-ht1a
Comparing watershed blacklocust afforestation and naturalrevegetation impacts on soilnitrogen on the Loess Plateauof China
期刊论文
Scientific Reportsvolume, 2016, 卷号: 6, 期号: 2016, 页码: 25048
作者:
Cui,BL(Cui,Buli)[1,3]
;
Wang,KB(Wang,Kaibo)[1]
;
Wang,Y(Wang,Yi)[1]
;
Wang,YQ(Wang,Yunqiang)[1]
;
Li,XR(Li,Xiangru)[1,2]
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2018/11/06
THE CAMPAIGN ONATMOSPHERIC AEROSOLRESEARCH NETWORKOF CHINACARE-CHINA
期刊论文
Bulletin of the American Meteorological Society, 2015, 卷号: 96, 期号: 7, 页码: 1137
作者:
Wang,XM(Wang,Xinming)[1]
;
Wang,GH(Wang,Gehui)[3]
;
Wang,PC(Wang,Pucai)[1]
;
Sun,J(Sun,Jie)[1]
;
Sun,Y(Sun,Yang)[1]
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2018/11/14
THE CAMPAIGN ONATMOSPHERIC AEROSOLRESEARCH NETWORKOF CHINACARE-CHINA
期刊论文
Bulletin of the American Meteorological Society, 2015, 卷号: 96, 期号: 7, 页码: 1137
作者:
Wang,L(Wang,Lu)[1]
;
Tian,SL(Tian,Shili)[1]
;
Miao,HY(Miao,Hongyan)[1]
;
Guo,YH(Guo,Yuhong)[1]
;
Gao,WK(Gao,Wenkang)[1]
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2018/11/21
Natural vegetation restoration is more beneficial to soil surface organic and inorganic carbon sequestration than tree plantation on the Loess Plateau of China
期刊论文
SCIENCE OF THE TOTAL ENVIRONMENT, 2014, 卷号: 485, 页码: 615-623
作者:
Jin, Z (Jin, Zhao)[ 1 ]
;
Dong, YS (Dong, Yunshe)[ 2 ]
;
Wang, YQ (Wang, Yunqiang)[ 1 ]
;
Wei, XR (Wei, Xiaorong)[ 3 ]
;
Wang, YF (Wang, Yafeng)[ 4 ]
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2018/11/26
Soil Carbon Distribution
Δ13c
Pedogenic Carbonate
Dic
Ecosystem Restoration
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