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上海药物研究所 [26]
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The unconventional prefoldin RPB5 interactor mediates the gravitropic response by modulating cytoskeleton organization and auxin transport in Arabidopsis
期刊论文
JOURNAL OF INTEGRATIVE PLANT BIOLOGY, 2022, 卷号: 64, 期号: 10, 页码: 1916-1934
作者:
Yang, Yi
;
Liu, Fang
;
Liu, Le
;
Zhu, Mingyue
;
Yuan, Jinfeng
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/03/07
Arabidopsis
auxin
cytoskeleton
PIN2
prefoldin (PFD)
unconventional prefoldin RPB5 interactor (URI)
Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Zhou, Yu-bo
;
Zhang, Yang-ming
;
Huang, Hong-hui
;
Shen, Li-jing
;
Han, Xiao-feng
收藏
  |  
浏览/下载:93/0
  |  
提交时间:2021/11/04
multiple myeloma
HDAC inhibitor
bisthianostat
pharmacodynamics
pharmacokinetics
phase 1a clinical trial
antitumor drug
Discovery of isopenicin A, a meroterpenoid as a novel inhibitor of tubulin polymerization
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020
作者:
Chen, Lin
;
Fan, Dong-Mei
;
Tang, Jian-Wei
;
An, Tao
;
Li, Xue
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  |  
浏览/下载:47/0
  |  
提交时间:2021/01/05
1-Phenyl-dihydrobenzoindazoles as novel colchicine site inhibitors: Structural basis and antitumor efficacy
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 177, 页码: 448-456
作者:
Jiang, Junhang
;
Zhang, Hao
;
Wang, Chongqing
;
Zhang, Qingsen
;
Fang, Shaoyu
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/07/01
Microtubule-targeting agents
Colchicine site inhibitors
Cis-trans photoisomerization
X-ray co-crystal structure
Water-soluble prodrug
Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Bousigonia mekongensis Inhibit Tubulin Polymerization
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 7, 页码: 10
作者:
Zhang, Yu
;
Goto, Masuo
;
Oda, Akifumi
;
Hsu, Pei-Ling
;
Guo, Ling-Li
收藏
  |  
浏览/下载:67/0
  |  
提交时间:2019/07/29
aspidosperma-type
monoterpenoid indole alkaloids
antiproliferative activity
tubulin inhibitor
Bousigonia mekongensis
3, 9-di-O-substituted coumestrols incorporating basic amine side chains act as novel apoptosis inducers with improved pharmacological selectivity
期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 85
作者:
Luo, Guoshun
;
Tang, Zhengpu
;
Li, Xinyu
;
Hou, Qiangqiang
;
Chen, Yu
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/12/05
Coumestrol
Estrogenic activity
Apoptosis
Cell cycle
Tubulin polymerization inhibitor
Tubulin colchicine site binding agent LL01 displays potent antitumor efficiency both in vitro and in vivo with suitable drug-like properties
期刊论文
Investigational New Drugs, 2019
作者:
Wu J.-D.
;
Cui Y.-J.
;
Zhou Y.-G.
;
Tang L.-Q.
;
Zhang C.-M.
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/11
Hepatocellular carcinoma
Liver microsome stability
Multidrug-resistance
Pharmacokinetics
Tubulin polymerization inhibitor
Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site
期刊论文
European Journal of Medicinal Chemistry, 2019, 卷号: Vol.163, 页码: 428-442
作者:
Wenlong Li
;
Wen Shuai
;
Honghao Sun
;
Feijie Xu
;
Yi Bi
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/13
Quinoline
Indole
Microtubule
Tubulin
inhibitor
Colchicine
binding
site
Antitumor
Synthesis, molecular properties prediction and biological evaluation of indole-vinyl sulfone derivatives as novel tubulin polymerization inhibitors targeting the colchicine binding site
期刊论文
Bioorganic Chemistry, 2019, 卷号: Vol.85, 页码: 49-59
作者:
Wenlong Li
;
Honghao Sun
;
Feijie Xu
;
Wen Shuai
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/12/13
Tubulin
inhibitor
Vinyl
sulfone
Indole
Colchicine
site
Drug-likeness
The Structure of MT189-Tubulin Complex Provides Insights into Drug Design
期刊论文
LETTERS IN DRUG DESIGN & DISCOVERY, 2019, 卷号: 16, 期号: 9, 页码: 1069-1073
作者:
Li, Zhongping
;
Ma, Lingling
;
Wu, Chengyong
;
Meng, Tao
;
Ma, Lanping
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/07/01
Crystal structure
tubulin
colchicine binding site
inhibitor
MT189
drug design
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