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上海药物研究所 [11]
山东大学 [9]
复旦大学上海医学院 [9]
四川大学 [6]
武汉大学 [6]
厦门大学 [2]
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期刊论文 [49]
会议论文 [4]
学位论文 [1]
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2021 [2]
2020 [1]
2019 [1]
2018 [2]
2017 [5]
2016 [5]
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Discovery, Structure-Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 13, 页码: 9458-9483
作者:
Huang, Huoming
;
Li, Xueping
;
Xie, Peng
;
Li, Xinwei
;
Xu, XueJun
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/08/17
Design, Synthesis, and Structure-Activity Relationship Exploration of Alkyl/Phenylalkyl Piperidine Analogues as Novel Highly Potent and Selective mu Opioid Receptor Agonists
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2021, 卷号: 12, 期号: 2, 页码: 285-299
作者:
Huang, Huoming
;
Li, Xinwei
;
Guo, Wei
;
Zhu, Chen
;
Qian, Yuanyuan
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/05/24
pain
opioid analgesic
SAR
selective MOR agonist
molecular dynamics simulations
Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxypheny1)-N-phenylpiperidine-1-carboxamide as novel potent analgesic
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 189, 页码: 14
作者:
Huang, Huoming
;
Wang, Wenli
;
Xu, Xuejun
;
Zhu, Chen
;
Wang, Yujun
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/01
Selective MOR agonists
Antinociception
Analgesic
Opioids
Molecular mechanism
Effect Analysis of Dexmedetomidine in Preventing Postoperative Hyperalgesia Induced by Remifentanil Anesthesia
期刊论文
BOLETIN DE MALARIOLOGIA Y SALUD AMBIENTAL, 2019, 卷号: 59, 期号: 3, 页码: 106-111
作者:
Zhang Jingchao
;
Yi Shuzhi
;
Zhang Fangxiang
;
Zhou Xiaona
;
Fang Hua
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/11
Hyperalgesia
VAS score
dexmedetomidine
tramadol
remifentanil
Tramadol for the treatment of catheter-related bladder discomfort: a randomized controlled trial
期刊论文
BMC Anesthesiology, 2018, 卷号: Vol.18 No.1
作者:
Shuying Li
;
Liping Song
;
Yushan Ma
;
Xuemei Lin
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/02/25
Catheter-related
bladder
discomfort
VAS
Tramadol
Treatment
Clinical opioids differentially induce co-internalization of mu- and delta-opioid receptors
期刊论文
MOLECULAR PAIN, 2018, 卷号: 14, 期号: 1, 页码: 1-15
作者:
Bao, Fenghua
;
Li, Chang-Lin
;
Lu, Ying-Jin
;
Zhang, Xu
;
Chen, Xu-Qiao
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2019/04/28
Protein-coupled Receptors
Knock-out Mice
Morphine Antinociceptive Tolerance
Dorsal-root Ganglia
Opiate Tolerance
Beta-arrestin
Desensitization
Trafficking
Dependence
Analgesia
Preemptive analgesia by using celecoxib combined with tramadol/APAP alleviates post-operative pain of patients undergoing total knee arthroplasty.
期刊论文
Phys Sportsmed, 2017, 卷号: Vol.45 No.3, 页码: 316-322
作者:
Xu Z
;
Zhang H
;
Luo J
;
Zhou A
;
Zhang J
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/02/25
Preemptive analgesia by using celecoxib combined with tramadol/APAP alleviates post-operative pain of patients undergoing total knee arthroplasty
期刊论文
PHYSICIAN AND SPORTSMEDICINE, 2017, 卷号: Vol.45 No.3, 页码: 316-322
作者:
Xu, Zhongwei
;
Zhang, Hua
;
Luo, Jiao
;
Zhou, Aiguo
;
Zhang, Jian
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/02/25
Preemptive
analgesia
celecoxib
tramadol
total
knee
arthroplasty
[Effects of Tramadol on Insulin Resistance during Cesarean Section Complicated with Gestational Diabetes Mellitus].
期刊论文
Sichuan Da Xue Xue Bao Yi Xue Ban, 2017, 卷号: Vol.48 No.3, 页码: 446-449
作者:
Lin YG
;
Huang W.
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2019/03/01
Gestational
diabetes
Mellitus
insulinresistance
Phosphoinositide
3-kinase
Tramadol
Tumor
necrosis
factor-α
Intracerebral microdialysis coupled to LC-MS/MS for the determination tramadol and its major pharmacologically active metabolite O-desmethyltramadol in rat brain microdialysates
期刊论文
DRUG TESTING AND ANALYSIS, 2017, 卷号: 9, 期号: 8
作者:
Liu, Mingzhou
;
Wang, Peng
;
Yu, Xuming
;
Dong, Guicheng
;
Yue, Jiang
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/05
tramadol
O-desmethyltramadol
microdialysis
LC-ESI-MS/MS
pharmacokinetics
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