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科研机构
上海药物研究所 [7]
中国科学院大学 [2]
山东大学 [2]
复旦大学上海医学院 [2]
中国医学科学院 北京... [2]
西安交通大学 [1]
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期刊论文 [19]
会议论文 [1]
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2021 [4]
2019 [2]
2018 [2]
2017 [1]
2016 [4]
2015 [1]
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Effects of Food on the Pharmacokinetic Properties and Mass Balance of Henagliflozin in Healthy Male Volunteers
期刊论文
CLINICAL THERAPEUTICS, 2021, 卷号: 43, 期号: 9, 页码: E264-E273
作者:
Chen, Zhen-dong
;
Chen, Qian
;
Zhu, Yun-ting
;
Zhang, Yi-fan
;
Zhan, Yan
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2022/01/04
henagliflozin
food effects
mass balance
pharmacokinetics
SGLT-2 inhibitor
Direct Cardiac Actions of the Sodium Glucose Co-Transporter 2 Inhibitor Empagliflozin Improve Myocardial Oxidative Phosphorylation and Attenuate Pressure-Overload Heart Failure
期刊论文
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2021, 卷号: 10, 期号: 6, 页码: 33
作者:
Li, Xuan
;
Lu, Qingguo
;
Qiu, Yunguang
;
do Carmo, Jussara M.
;
Wang, Zhen
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  |  
浏览/下载:25/0
  |  
提交时间:2021/05/24
cardiac hypertrophy
cardiac metabolism
cardiomyocytes
sodium glucose cotransporter 2
transverse aortic constriction
Tolerability, Pharmacokinetic, and Pharmacodynamic Profiles of Henagliflozin, a Novel Selective Inhibitor of Sodium-Glucose Cotransporter 2, in Healthy Subjects Following Single- and Multiple-dose Administration
期刊论文
CLINICAL THERAPEUTICS, 2021, 卷号: 43, 期号: 2, 页码: 396-409
作者:
Zhang, Yi-fan
;
Liu, Yan-mei
;
Yu, Chen
;
Wang, Ya-ting
;
Zhan, Yan
收藏
  |  
浏览/下载:67/0
  |  
提交时间:2021/05/24
diabetes
henagliflozin
pharmacodynamics
pharmacokinetics
SGLT-2 inhibitors
Characterization and quantitative determination of henagliflozin metabolites in humans
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 192, 页码: 8
作者:
Chen, Zhendong
;
Li, Liang
;
Zhan, Yan
;
Zhang, Yifan
;
Liu, Haiyan
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/05/24
Henagliflozin
Metabolism
LC-MS/MS
Design, synthesis and biological evaluation of 6-deoxy O-spiroketal C-arylglucosides as novel renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 180, 页码: 398-416
作者:
Wang, Yibing
;
Lou, Yang
;
Wang, Jiang
;
Li, Dan
;
Chen, Hui
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  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
SGLT2 inhibitors
Diabetes
Sugar modification
Structure-activity relationship
Urinary glucose excretion
Oral glucose tolerance
A Survey of the FDA's Adverse Event Reporting System Database Concerning Urogenital Tract Infections and Sodium Glucose Cotransporter-2Inhibitor Use
期刊论文
2019, 卷号: 10, 期号: 3, 页码: 1043-1050
作者:
Shen, Juan
;
Yang, Jincheng
;
Zhao, Bin
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  |  
浏览/下载:8/0
  |  
提交时间:2020/01/03
Adverse drug reactions
FAERS
Sodium glucose cotransporter-2 inhibitors
Urogenital tract infections
The Sodium-Glucose Cotransporter 2 Inhibitor Dapagliflozin Prevents Renal and Liver Disease in Western Diet Induced Obesity Mice
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 卷号: 19, 期号: 1
作者:
Wang, Dong
;
Luo, Yuhuan
;
Wang, Xiaoxin
;
Orlicky, David J.
;
Myakala, Komuraiah
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  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
obesity
SGLT2
dapagliflozin
fibrosis
lipid
inflammation
Efficacy and safety of sodium-glucose cotransporter 2 inhibitors in patients with type 2 diabetes and moderate renal function impairment: A systematic review and meta-analysis
期刊论文
2018, 卷号: 140, 页码: 295-303
作者:
Zhang, Lin[1,2]
;
Zhang, Mei[3]
;
Lv, Qingguo[1]
;
Tong, Nanwei[1]
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/06
Ketosis and diabetic ketoacidosis in response to SGLT2 inhibitors: Basic mechanisms and therapeutic perspectives.[Review]
期刊论文
Diabetes/Metabolism Research and Reviews, 2017, 卷号: Vol.33 No.5, 页码: e2886
作者:
Qiu, Hongyu 1,2
;
Novikov, Aleksandra 2,3
;
Vallon, Volker *,2,3
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/02/25
diabetic ketoacidosis
ketogenesis
ketone body reabsorption
ketosis
kidney
sodium glucose cotransporter
Postnatal developmental changes of the small intestinal villus height, crypt depth and hexose transporter mrna expression in supplemental feeding and grazing goats
期刊论文
Small ruminant research, 2016, 卷号: 141, 页码: 106-112
作者:
Li, Hengzhi
;
Ran, Tao
;
He, Zhixiong
;
Yan, Qiongxian
;
Tang, Shaoxun
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2019/05/09
Villus
Crypt
Hexose transporter
Intestine
Feeding regime
Goat
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