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上海药物研究所 [5]
复旦大学上海医学院 [2]
厦门大学 [1]
生物物理研究所 [1]
武汉病毒研究所 [1]
海洋研究所 [1]
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期刊论文 [12]
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2012 [2]
2011 [3]
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Virology [1]
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Development of a luciferase-based biosensor to assess enterovirus 71 3c protease activity in living cells
期刊论文
Scientific reports, 2017, 卷号: 7, 页码: 11
作者:
Zhang, Yuan
;
Ke, Xianliang
;
Zheng, Caishang
;
Liu, Yan
;
Xie, Li
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/05/08
Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 124, 页码: 981-991
作者:
Ma, Guang-Hui
;
Ye, Yan
;
Zhang, Dan
;
Xu, Xin
;
Si, Pei
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  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
HFMD
EV71 3C(Pro)
Non-peptidyl inhibitor
Virtual screening
The Enterovirus Protease Inhibitor Rupintrivir Exerts Cross-Genotypic Anti-Norovirus Activity and Clears Cells from the Norovirus Replicon
期刊论文
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 卷号: 58, 期号: 8, 页码: 4675-4681
Rocha-Pereira, J.
;
Nascimento, M. S. J.
;
Ma, Qingjun
;
Hilgenfeld, R.
;
Neyts, J.
;
Jochmans, D.
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2014/09/08
RHINOVIRUS 3C PROTEASE
IN-VITRO
NORWALK VIRUS
SUBSTRATE-SPECIFICITY
ANTIVIRAL ACTIVITY
POTENT INHIBITOR
GASTROENTERITIS
MODEL
REPLICATION
2'-C-METHYLCYTIDINE
Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases
期刊论文
ANTIVIRAL RESEARCH, 2014, 卷号: 103, 页码: 17-24
作者:
van der Linden, Lonneke
;
Ulferts, Rachel
;
Nabuurs, Sander B.
;
Kusov, Yuri
;
Liu, Hong
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  |  
浏览/下载:8/0
  |  
提交时间:2019/01/08
Cell-based assay
Protease
3C(pro)
Picornavirus
Inhibitor
Structures of Enterovirus 71 3C proteinase (strain E2004104-TW-CDC) and its complex with rupintrivir
期刊论文
http://dx.doi.org/10.1107/S0907444913002862, 2013
Wu, Caiming
;
Cai, Qixu
;
Chen, Chen
;
Li, Ning
;
Peng, Xuanjia
;
Cai, Yaxian
;
Yin, Ke
;
Chen, Xinsheng
;
Wang, Xiaolong
;
Zhang, Rongfu
;
Liu, Lijie
;
Chen, Shuhui
;
Li, Jian
;
Lin, Tianwei
;
李剑
;
林天伟
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2015/07/22
CRYSTAL-STRUCTURES
ACTIVE-SITE
PROTEASE
FOOT
REFINEMENT
INHIBITORS
DESIGN
Rupintrivir is a promising candidate for treating severe cases of enterovirus-71 infection: Evaluation of antiviral efficacy in a murine infection model
期刊论文
ANTIVIRAL RESEARCH, 2013, 卷号: 97, 期号: 3
作者:
Zhang, Xiaonan
;
Song, Zhigang
;
Qin, Boyin
;
Zhang, Xiaoling
;
Chen, Lixiang
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  |  
浏览/下载:1/0
  |  
提交时间:2019/12/19
Enterovirus 71
Hand-foot-and-mouse disease
Rupintrivir
Improved synthesis of rupintrivir
期刊论文
SCIENCE CHINA-CHEMISTRY, 2012, 卷号: 55, 期号: 6, 页码: 1101-1107
作者:
Lin DaiZong
;
Qian WangKe
;
Hilgenfeld, Rolf
;
Jiang HuaLiang
;
Chen KaiXian
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  |  
浏览/下载:25/0
  |  
提交时间:2019/01/08
rupintrivir
AG7088
synthesis
improvedsynthesisofrupintrivir
期刊论文
sciencechinachemistry, 2012, 卷号: 55, 期号: 6, 页码: 1101
作者:
Lin Daizong
;
Qian Wangke
;
Hilgenfeld Rolf
;
Jiang Hualiang
;
Chen Kaixian
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/07/01
RHINOVIRUS PROTEASE INHIBITOR
STRUCTURE-BASED DESIGN
BIOLOGICAL EVALUATION
ENTEROVIRUS 71
INTERMEDIATE
PROTEINASE
EFFICIENT
AG7088
rupintrivir
AG7088
synthesis
Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design
期刊论文
JOURNAL OF VIROLOGY, 2011, 卷号: 85, 期号: 19, 页码: 10319-10331
作者:
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design
期刊论文
JOURNAL OF VIROLOGY, 2011, 卷号: 85, 期号: 19, 页码: 10319-10331
Lu, Guangwen
;
Qi, Jianxun
;
Chen, Zhujun
;
Xu, Xiang
;
Gao, Feng
;
Lin, Daizong
;
Qian, Wangke
;
Liu, Hong
;
Jiang, Hualiang
;
Yan, Jinghua
;
Gao, George F
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2013/12/25
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