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Genomic characterization reveals distinct mutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract
期刊论文
CANCER COMMUNICATIONS, 2022
作者:
Wu, Huanwen
;
Yu, Zicheng
;
Liu, Yueping
;
Guo, Lei
;
Teng, Lianghong
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/12/22
Neuroendocrine carcinomas
Gastrointestinal tract
Genomic characterization
Heterogeneity
Therapeutic implications
An overview of kinase downregulators and recent advances in discovery approaches
期刊论文
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 卷号: 6
作者:
Wang, Beilei
;
Wu, Hong
;
Hu, Chen
;
Wang, Haizhen
;
Liu, Jing
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/01/25
NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms
期刊论文
CELL REPORTS, 2021, 卷号: 36, 期号: 7, 页码: 20
作者:
Zhou, Zikai
;
He, Guiqin
;
Zhang, Xiaoyun
;
Lv, Xin
;
Zhang, Xiaolin
收藏
  |  
浏览/下载:67/0
  |  
提交时间:2021/11/04
Repurposing of Kinase Inhibitors for Treatment of COVID-19
期刊论文
PHARMACEUTICAL RESEARCH, 2020, 卷号: 37
作者:
Weisberg, Ellen
;
Parent, Alexander
;
Yang, Priscilla L.
;
Sattler, Martin
;
Liu, Qingsong
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  |  
浏览/下载:34/0
  |  
提交时间:2020/10/26
Coronavirus
SARS-CoV-2
SARS-CoV
MERS-CoV
kinase inhibitors
pharmacokinetics
antiviral therapy
COVID-19
SHR-A1403, a novel c-Met antibody-drug conjugate, exerts encouraging anti-tumor activity in c-Met-overexpressing models
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 7, 页码: 971-979
作者:
Yang, Chang-yong
;
Wang, Lei
;
Sun, Xing
;
Tang, Mi
;
Quan, Hai-tian
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
SHR-A1403
c-Met ADC
anti-tumor
patient-derived xenograft (PDX)
molecular mechanisms
HoxA10 Facilitates SHP-1-Catalyzed Dephosphorylation of p38 MAPK/STAT3 To Repress Hepatitis B Virus Replication by a Feedback Regulatory Mechanism
期刊论文
JOURNAL OF VIROLOGY, 2019, 卷号: 93, 期号: 7
作者:
Yang, Qingyu
;
Zhang, Qi
;
Zhang, Xuewu
;
You, Lei
;
Wang, Wenbiao
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/12/05
hepatitis B virus infection and pathogenesis
homeobox protein A10
HoxA10
SH2-containing protein tyrosine phosphatase 1
SHP-1
signal transducer and activator of transcription 3
p38 MAPK-STAT3 signaling pathway
mitogen-activated protein kinase
metabolismanddispositionofpyrotinibinhealthymalevolunteerscovalentbindingwithhumanplasmaprotein
期刊论文
actapharmacologicasinica, 2019, 卷号: 40, 期号: 7, 页码: 980
作者:
Meng Jian
;
Liu Xiaoyun
;
Ma Sheng
;
Zhang Hua
;
Yu Songda
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2020/07/01
pyrotinib
EGFR/HER2 dual tyrosine kinase inhibitor
breast cancer
drug metabolism
drug disposition
human plasma
covalent binding
Ligand-activated epidermal growth factor receptor (EGFR) signaling governs endocytic trafficking of unliganded receptor monomers by non-canonical phosphorylation
期刊论文
The Journal of biological chemistry, 2018, 卷号: 293, 期号: 7, 页码: 2288-2301
作者:
Tanaka, Tomohiro
;
Zhou, Yue
;
Ozawa, Tatsuhiko
;
Okizono, Ryuya
;
Banba, Ayako
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  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
TLR7 (Toll-Like Receptor 7) Facilitates Heme Scavenging Through the BTK (Bruton Tyrosine Kinase)-CRT (Calreticulin)-LRP1 (Low-Density Lipoprotein Receptor-Related Protein-1)-Hx (Hemopexin) Pathway in Murine Intracerebral Hemorrhage
期刊论文
STROKE, 2018, 卷号: 49, 期号: 12
作者:
Wang, Gaiqing
;
Guo, Zhenni
;
Tong, Lusha
;
Xue, Fang
;
Krafft, Paul R.
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/12/05
Bruton tyrosine kinase
calreticulin
heme scavenging
imiquimod
intracerebral hemorrhage
toll-like receptor
The E3 ligases Itch and WWP2 cooperate to limit T(H)2 differentiation by enhancing signaling through the TCR
期刊论文
NATURE IMMUNOLOGY, 2018, 卷号: 19, 期号: 7, 页码: 766-+
作者:
Aki, Daisuke
;
Li, Hui
;
Zhang, Wen
;
Zheng, Mingke
;
Liu, Yun-Cai
收藏
  |  
浏览/下载:79/0
  |  
提交时间:2019/04/28
Cd4(+) T-cells
Ubiquitin Ligases
Immune-response
Moth-eaten
Cbl-b
Activation
Protein
Degradation
Shp-1
Ubiquitylation
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