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SL010110, a lead compound, inhibits gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and improves glucose homeostasis in diabetic mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Ren, Yu-ran
;
Ye, Yang-liang
;
Feng, Ying
;
Xu, Ti-fei
;
Shen, Yu
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/05/24
SL010110
gluconeogenesis
primary mouse hepatocytes
PEPCK1
acetylation
degradation
Activation of SIK1 by phanginin A inhibits hepatic gluconeogenesis by increasing PDE4 activity and suppressing the cAMP signaling pathway
期刊论文
MOLECULAR METABOLISM, 2020, 卷号: 41, 页码: 15
作者:
Liu, Siwen
;
Huang, Suling
;
Wu, Xingde
;
Feng, Ying
;
Shen, Yu
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  |  
浏览/下载:55/0
  |  
提交时间:2020/12/24
Salt-inducible kinase 1
Phanginin A
Phosphodiesterase 4
Gluconeogenesis
cAMP
TCDD promotes liver fibrosis through disordering systemic and hepatic iron homeostasis
期刊论文
JOURNAL OF HAZARDOUS MATERIALS, 2020, 卷号: 395, 页码: 1-8
作者:
Li, Changying
;
Liu, Yingying
;
Dong, Zheng
;
Xu, Ming
;
Gao, Ming
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2021/09/14
TCDD
Liver fibrosis
Cideb
Hepatocyte apoptosis
Iron deposition
Discovery of a Potent and Selective NF-kappa B-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 8, 页码: 4388-4407
作者:
Li, Zhiqiang
;
Li, Xinzhi
;
Su, Ming-Bo
;
Gao, Li-Xin
;
Zhou, Yu-Bo
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  |  
浏览/下载:28/0
  |  
提交时间:2020/07/01
Nimesulide increases the aldehyde oxidase activity of humans and rats
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Zhou, Lei
;
Pang, Xiao-yan
;
Hou, Xiang-yu
;
Liu, Lu
;
Guo, Zi-tao
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  |  
浏览/下载:12/0
  |  
提交时间:2020/07/01
nimesulide
aldehyde oxidase
induction
methotrexate
hepatocytes
pharmacokinetics
drug interaction
The Protective Roles of PPAR alpha Activation in Triptolide-Induced Liver Injury
期刊论文
TOXICOLOGICAL SCIENCES, 2019, 卷号: 171, 期号: 1, 页码: 1-12
作者:
Hu, Dan-Dan
;
Zhao, Qi
;
Cheng, Yan
;
Xiao, Xue-Rong
;
Huang, Jian-Feng
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  |  
浏览/下载:12/0
  |  
提交时间:2020/03/26
liver injury
metabolomics
PPAR alpha
acylcarnitines
Metabolic Activation of Myristicin and Its Role in Cellular Toxicity
期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 卷号: 67, 期号: 15, 页码: 4328-4336
作者:
Zhu, Xu
;
Wang, Yi-Kun
;
Yang, Xiao-Nan
;
Xiao, Xue-Rong
;
Zhang, Ting
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  |  
浏览/下载:50/0
  |  
提交时间:2019/05/24
myristicin
1 '-hydroxymyristicin
metabolic activation
metabolomics
PFOA and PFOS interact with superoxide dismutase and induce cytotoxicity in mouse primary hepatocytes: A combined cellular and molecular methods
期刊论文
ENVIRONMENTAL RESEARCH, 2019, 卷号: 175, 页码: 63-70
作者:
Xu, Mengchen
;
Wan, Jingqiang
;
Niu, Qigui
;
Liu, Rutao
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  |  
浏览/下载:15/0
  |  
提交时间:2019/12/11
Perfluorooctanoic acid
Perfluorooctanesulfonic acid
Superoxide
dismutase
Oxidative stress
Interaction mechanisms
Molecular mechanism of CAT and SOD activity change under MPA-CdTe quantum dots induced oxidative stress in the mouse primary hepatocytes
期刊论文
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2019, 卷号: 220
作者:
Hao, Minglu
;
Liu, Rutao
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/12/11
Quantum dot
CAT
SOD
Oxidative stress
Apoptosis
sulfuretinprotectshepaticcellsthroughregulationofroslevelsandautophagicflux
期刊论文
actapharmacologicasinica, 2019, 卷号: 40, 期号: 7, 页码: 908
作者:
Lu Yuting
;
Xiao Yufeng
;
Li Yufeng
;
Li Jia
;
Nan Fajun
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/07/01
sulfuretin
palmitate
mitophagy
autophagic flux
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