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Furmonertinib (Alflutinib, AST2818) is a potential positive control drug comparable to rifampin for evaluation of CYP3A4 induction in sandwich-cultured primary human hepatocytes
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Wu, Ya-li
;
Xue, Ya-ru
;
Guo, Zi-tao
;
Chen, Zhen-dong
;
Ge, Xin-yu
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/08/17
furmonertinib (alflutinib
AST2818)
quantitative proteomics
sandwich-cultured human hepatocytes
Functional Proliferating Human Hepatocytes: In Vitro Hepatocyte Model for Drug Metabolism, Excretion, and Toxicity
期刊论文
DRUG METABOLISM AND DISPOSITION, 2021, 卷号: 49, 期号: 4, 页码: 305-313
作者:
Qiao, Shida
;
Feng, Sisi
;
Wu, Zhitao
;
He, Ting
;
Ma, Chen
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/05/24
Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3
期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:
Xie, Wei
;
Ye, Yangliang
;
Feng, Ying
;
Xu, Tifei
;
Huang, Suling
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/01/08
cAMP
gluconeogenesis
linderane
phosphodiesterase
type 2 diabetes
Detection of nanocarrier potentiation on drug induced phospholipidosis in cultured cells and primary hepatocyte spheroids by high content imaging and analysis
期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2018, 卷号: 348, 页码: 54, 66
作者:
Zhang, Xihui
;
Yang, Liecheng
;
Liu, Yongming
;
Song, Zhentao
;
Zhao, Jian
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2018/12/28
Phospholipidosis
Nanocarrier
Primary hepatocyte
Spheroid
High content screening
Paper supported long-term 3D liver co-culture model for the assessment of hepatotoxic drugs
期刊论文
TOXICOLOGY RESEARCH, 2018, 卷号: 7, 期号: 1, 页码: 13-21
作者:
Wang, Yaqing
;
Su, Wentao
;
Qin, Jianhua
;
Jiang, Lei
;
Liu, Yang
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  |  
浏览/下载:31/0
  |  
提交时间:2019/06/20
Insulin suppresses the AMPK signaling pathway to regulate lipid metabolism in primary cultured hepatocytes of dairy cows.
期刊论文
JOURNAL OF DAIRY RESEARCH, 2018, 卷号: Vol.85 No.2, 页码: 157-162
作者:
Li Xinwei
;
Li Yu
;
Ding Hongyan
;
Dong Jihong
;
Zhang Renhe
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/26
Insulin
AMPK
alpha
dairy
cow
hepatocytes
The involvement of multidrug and toxin extrusion protein 1 in the distribution and excretion of berberine
期刊论文
XENOBIOTICA, 2018, 卷号: 48, 期号: 3, 页码: 314-323
作者:
Xiao, Ling
;
Xue, Yaru
;
Zhang, Cuifeng
;
Wang, Le
;
Lin, Yunfei
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  |  
浏览/下载:38/0
  |  
提交时间:2019/01/08
Berberine
MATE1
hepatobiliary distribution
excretion
DDIs
Physiological oxygen tension reduces hepatocyte dedifferentiation in in vitro culture
期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7
作者:
Guo, Ren
;
Xu, Xinxiu
;
Lu, Yuting
;
Xie, Xin
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  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Functional human induced hepatocytes (hiHeps) with bile acid synthesis and transport capacities: A novel in vitro cholestatic model
期刊论文
Scientific Reports, 2016, 卷号: 6
作者:
Ni, Xuan
;
Gao, Yimeng
;
Wu, Zhitao
;
Ma, Leilei
;
Chen, Chen
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2019/01/08
Inhibition of hepatic cytochrome P450 enzymes and sodium/bile acid cotransporter exacerbates leflunomide-induced hepatotoxicity
期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 3, 页码: 415-424
作者:
Ma, Lei-lei
;
Wu, Zhi-tao
;
Wang, Le
;
Zhang, Xue-feng
;
Wang, Jing
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
leflunomide
hepatotoxicity
CYPs
teriflunomide
aminobenzotriazole
proadifen
NTCP
cholestasis
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