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期刊论文 [57]
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Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 45, 页码: 9
作者:
Liu, Xiao
;
Yang, Su
;
Hart, Jonathan R.
;
Xu, Yingna
;
Zou, Xinyu
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/01/04
phosphoinositide 3-kinase (PI3K)
activation
inhibition
activity-dependent conformational changes
Silencing PDK1 limits hypoxia-induced pulmonary arterial hypertension in mice via the Akt/p70S6K signaling pathway
期刊论文
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2019, 卷号: 18, 期号: 1
作者:
Di, Ruomin
;
Yang, Zhongzhou
;
Xu, Peng
;
Xu, Yingjia
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  |  
浏览/下载:19/0
  |  
提交时间:2019/12/05
phosphoinositide-dependent protein kinase-1
pulmonary arterial hypertension
protein kinase B
hypoxia
Immunostimulatory Effects of Chitooligosaccharides on RAW 264.7 Mouse Macrophages via Regulation of the MAPK and PI3K/Akt Signaling Pathways
期刊论文
MARINE DRUGS, 2019, 卷号: 17, 期号: 1, 页码: 12
作者:
Yang, Yue
;
Xing, Ronge
;
Liu, Song
;
Qin, Yukun
;
Li, Kecheng
收藏
  |  
浏览/下载:75/0
  |  
提交时间:2019/08/28
chitooligosaccharide
immunostimulatory activity
RAW 264
7 cells
mitogen-activated protein kinases (MAPK)
phosphoinositide 3-kinases (PI3K)
Akt
Mechanochemical modeling of neutrophil migration based on four signaling layers, integrin dynamics, and substrate stiffness
期刊论文
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, 2018, 卷号: 17, 期号: 6, 页码: 1611-1630
作者:
Feng SL(冯世亮)
;
Zhou LW(周吕文)
;
Zhang Y(章燕)
;
Lv SQ(吕守芹)
;
Long M(龙勉)
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  |  
浏览/下载:56/0
  |  
提交时间:2019/05/30
Chemotaxis
Cytoskeletal remodeling
Mathematical model
Biochemical
Biomechanical
DCZ3301, a novel aryl-guanidino inhibitor, induces cell apoptosis and cell cycle arrest via suppressing the PI3K/AKT pathway in T-cell leukemia/lymphoma
期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2018, 卷号: 50, 期号: 7, 页码: 643-650
作者:
Xiao, Wenqin
;
Li, Bo
;
Sun, Xi
;
Yu, Dandan
;
Xie, Yongsheng
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  |  
浏览/下载:82/0
  |  
提交时间:2019/01/08
DCZ3301
T-cell leukemia/lymphoma
apoptosis
cell cycle
PI3K/AKT
A11, a novel diaryl acylhydrazone derivative, exerts neuroprotection against ischemic injury in vitro and in vivo
期刊论文
Acta pharmacologica Sinica, 2018
作者:
Feng, Hong-Xuan
;
Li, Chun-Pu
;
Shu, Shuang-Jie
;
Liu, Hong
;
Zhang, Hai-Yan
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  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
PDK1-WNK1 signaling is affected by HBx and involved in the viability and metastasis of hepatic cells
期刊论文
ONCOLOGY LETTERS, 2018, 卷号: 15, 期号: 4
作者:
Li, Chaoying
;
Lin, Cong
;
Jiang, Ying
;
Cong, Xianling
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/05
3-phosphoinositide-dependent protein kinase-1
hepatitis B virus-encoded X antigen
hepatocellular carcinoma
Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis
期刊论文
MOLECULAR CELL, 2018, 卷号: 71, 期号: 2, 页码: 201-+
作者:
Zhang, Yajuan
;
Wang, Xiongjun
;
Cai, Guoqing
;
Liu, Ruilong
;
Gao, Hong
收藏
  |  
浏览/下载:66/0
  |  
提交时间:2019/04/28
Tumor-associated Macrophages
Cancer-cell Metabolism
Blood-brain-barrier
Phosphoglycerate Kinase
Human Glioblastoma
Microenvironment
Progression
Expression
Pkm2
Pdk1
Insulin and 20-hydroxyecdysone oppose each other in the regulation of phosphoinositide-dependent kinase-1 expression during insect pupation
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 48, 页码: 18613-18623
作者:
Pan, Jing
;
Di, Yu-Qin
;
Li, Yong-Bo
;
Chen, Cai-Hua
;
Wang, Jin-Xing
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  |  
浏览/下载:4/0
  |  
提交时间:2019/12/11
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