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上海药物研究所 [4]
南华大学 [2]
山东大学 [2]
中南大学 [2]
大连理工大学 [1]
武汉大学 [1]
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期刊论文 [15]
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2019 [2]
2018 [2]
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TGF-beta 1 promotes the osteoinduction of human osteoblasts via the PI3K/AKT/mTOR/S6K1 signalling pathway
期刊论文
MOLECULAR MEDICINE REPORTS, 2019, 卷号: 19, 页码: 3505-3518
作者:
Zhang, Zhaodong
;
Zhang, Xiuzhi
;
Zhao, Dewei
;
Liu, Baoyi
;
Wang, Benjie
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/12/02
transforming growth factor 1
osteoinduction
phosphatidylinositol 3-kinase
protein kinase B
mammalian target of rapamycin
S6 kinase 1
Orthosilicic Acid Accelerates Bone Formation in Human Osteoblast-Like Cells Through the PI3K-Akt-mTOR Pathway
期刊论文
BIOLOGICAL TRACE ELEMENT RESEARCH, 2019, 卷号: 190, 期号: 2, 页码: 327-335
作者:
Zhou, Hongming
;
Jiao, Guangjun
;
Dong, Meng
;
Chi, Hai
;
Wang, Hongliang
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/12/11
Orthosilicic acid
Phosphatidylinositol-4
5-bisphosphate 3-kinase
(PI3K)
Protein kinase B (PKB
Akt)
Mammalian target of rapamycin
(mTOR)
Osteoporosis
Orthosilicic Acid Accelerates Bone Formation in Human Osteoblast-Like Cells Through the PI3K–Akt–mTOR Pathway
期刊论文
Biological Trace Element Research, 2018
作者:
Zhou H.
;
Jiao G.
;
Dong M.
;
Chi H.
;
Wang H.
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/11
Mammalian target of rapamycin (mTOR)
Orthosilicic acid
Osteoporosis
Phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)
Protein kinase B (PKB/Akt)
Inhibition of autophagy via activation of PI3K/Akt/mTOR pathway contributes to the protection of hesperidin against myocardial ischemia/reperfusion injury
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2018, 卷号: 42, 期号: 4
作者:
Li, Xuefei
;
Hu, Xiaorong
;
Wang, Jichun
;
Xu, Weipan
;
Yi, Chunfeng
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/05
autophagy
hesperidin
phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin
myocardial ischemia/reperfusion injury
LY294002
Metformin, beyond an insulin sensitizer, targeting heart and pancreatic β cells
期刊论文
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017, 卷号: 1863, 期号: 8, 页码: 1984-1990
作者:
Yang, Xin
;
Xu, Zhipeng
;
Zhang, Chunlan
;
Cai, Zixin
;
Zhang, Jingjing*
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/12/03
A1c
glycated hemoglobin
AACE
American Association of Clinical Endocrinologists
ACC
acetyl-CoA carboxylase
ADA
American Diabetes Association
Akt/PKB
tyrosine kinase/protein kinase B
AMP
adenosine monophosphate
AMPK
adenosine monophosphate-activated protein
Ang II
angiotensin II
ATP
adenosine triphosphate
BAT
brown adipose tissue
CHOP
CEBP-homologous protein
CEBP
CCAAT enhancer binding protein
CoA
coenzyme A
DPP
Diabetes Prevention Program
EASD
European Association for the Study of Diabetes
eNOS
endothelial nitric oxide synthase
ER
endoplasmic reticulum
FDA
Food and Drug Administration
FFA
free fatty acid
FOXO1
forkhead box protein O1
G6P
glucose 6-phosphate
GDM
gestational diabetes mellitus
GIPR
glucose-dependent insulinotropic polypeptide receptor
GLP-1R
glucagon-like peptide-1 receptor
GLUT1
glucose transporter-1
GLUT4
glucose transporter type 4
GLUTs
glucose transporters
G6P
glucose 6-phosphate, glucose transporter-1
GPR40
G protein-coupled receptor 40
HbA1c
hemoglobin A1c
HGP
hepatic glucose production
HSL
hormone sensitive lipase
IL-6
interleukin 6
INS-1
insulinoma cells in rat
IR
insulin resistance
IRS-1
insulin receptor substrate 1
JNK
c-Jun. N-terminal kinase
Kir6.2
inwardly rectifying potassium/kalium channel
LDs
lipid droplets
LDL
low density lipoprotein
LV
left ventricular
MIN6 cells
mouse insulinoma cells
MAPK
mitogen-activated protein kinases
mPTP
mitochondrial permeability transition pore opening
mTOR
mammalian target of rapamycin
NADPH
nicotinamide adenine dinucleotide phosphate
NF-kappaB
nuclear factors-kappa B
NIT-1 cells
insulinoma cells
p70S6K
p70 ribosomal S6 kinase
PA
palmitic acid
NOS
NADPH oxidase
p38 MAPK
p38 mitogen-activated protein kinase
PA
palmitic acid
PCOS
polycystic ovary syndrome
PGC-1α
peroxisome proliferator-activated receptor-g coactivator-1α
PI3K
phosphatidylinositol 3-kinase
PKB
protein kinase B
PKC
protein kinase C
PPARα
peroxisome-proliferator activated receptor α
PTP
permeability transition pore
RCT
randomized controlled trial
RISK
reperfusion injury salvage kinase
ROS
reactive oxygen species
SERCA2
reticulum sarcoplasmic Ca2 +-ATPase
RISK
reperfusion injury salvage kinase
Smad3
mothers against decapentaplegic homolog 3
SRC-2
steroid receptor coactivator 2
T1DM
Type 1 diabetes mellitus
T2DM
Type 2 diabetes mellitus
TGFβ1
transforming growth factor β1
TLR4
Toll-like receptor
TNF-α
tumor necrosis factor α
TR4
testicular receptor 4
UKPDS
United Kingdom Prospective Diabetes Study
VLDL
very low density lipoprotein
Metformin
Pancreatic β Cells
Heart failure
Insulin sensitizer
Renoprotective approaches and strategies in acute kidney injury
期刊论文
Pharmacology and Therapeutics, 2016, 卷号: 163, 页码: 58-73
作者:
Yang, Yuan
;
Song, Meifang
;
Liu, Yu
;
Liu, Hong
;
Sun, Lin
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/12/03
ACTH
Adrenocorticotropic hormone
AIF
Apoptosis inducing factor
AKI
Acute kidney injury
BMSC
Bone marrow derived stem cells
CIN
Contrast-induced nephropathy
COMP-Ang1
Cartilage oligomeric matrix protein-angiopoietin-1
CysLT1R
Cysteinyl leukotriene-1 receptor
DMARD
Disease-modifying antirheumatic drugs
eNOS
Endothelial nitric oxide synthase
eEPCs
Endothelial progenitor cells
HDAC
Histone deacetylase
HSPC
Hematopoietic stem and progenitor cells
IRI
Ischemia–reperfusion injury
ICAM-1
Intercellular adhesion molecule-1
JNK
c-Jun N-terminal kinase
KIF3B
Kinesin family member 3B
KIM-1
Kidney injury molecule 1
MAPK
Mitogen-activated protein kinase
MCP-1
Monocyte chemotactic protein-1
α-MSH
Alpha-melanocyte-stimulating hormone
MFG-E8
Milk fat globule-epidermal growth factor-factor VIII
MPT
Mitochondrial permeability transition
MSCs
Mesenchymal stem cells
NGAL
Neutrophil gelatinase-associated lipocalin
MDM2
Murine double minute-2
MMP-2
Matrix metallopeptidase 2
mTOR
Mammalian target of rapamycin
PI3K
Phosphatidylinositol-3 kinase
PACAP
Pituitary adenylate cyclase activating polypeptide
RAAS
Renin–angiotensin–aldosterone system
RANTES
Regulated upon activation normal T-cell expressed and secreted
RIP1
Receptor-interacting protein 1
TNF-α
Tumor necrosis factor-alpha
TWEAK
TNF-like weak inducer of apoptosis
VDRA
Vitamin D receptor agonist
Acute kidney injury
Kidney protection
Kidney repair
Renoprotection
Ischemia–reperfusion
Nephrotoxicity
Will targeting PI3K/Akt/mTOR signaling work in hematopoietic malignancies?
期刊论文
2016, 卷号: 3, 页码: 31
作者:
Gao Yanan
;
Yuan Chase Y
;
Yuan Weiping
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/01/04
Phosphatidylinositol 3-kinase (PI3K)
genetic analysis
hematological malignancies
mammalian target of rapamycin (mTOR)
protein kinase B (Akt)
Autophagy: A double-edged sword in intervertebral disk degeneration
期刊论文
Clinica chimica acta, international journal of clinical chemistry, 2016, 卷号: 457, 页码: 27-35
作者:
Zhang, Shu-Jun
;
Yang, Wei
;
Wang, Cheng
;
He, Wen-Si
;
Deng, Hai-Yang
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/12/27
IVD
intervertebral disk
NP
nucleus pulposus
AF
annulus fibrosus
CEPs
cartilaginous endplates
ECM
extracellular matrix
Col II
type II collagen
Col I
type I collagen
IDD
intervertebral disk degeneration
LBP
low back pain
miRNAs
microRNAs
ADAMTS
a disintegrin and metalloprotease with thrombospondin motif
MMP
matrix metalloproteinases
HSC70
heat shock cognate protein of 70 kDa
LAMP2A
lysosome-associated membrane protein type-2 A
Atg
autophagy-related genes
ULK
uncoordinated-51-like kinase
PI3KCIII
class III phosphatidylinositol 3-kinase
mTORC1
mammalian target of rapamycin complex 1
DFCP1
double FYVE-containing protein 1
3-MA
3-methyladenine
LC3
microtubule-associated protein 1 light chain 3
PE
phosphatidyl ethanolamine
LAMP-2
lysosomal membrane protein 2
TNF-α
tumor necrosis factor-α
IL-1β
interleukin-1β
NF-κB
nuclear factor-κB
JNK
c-Jun N-terminal kinase
SIRT1
silent mating type information regulator 2 homolog 1
TGF-β1
transforming growth factor-β1
ERK1/2
extracellular signal-regulated kinase 1/2
GRP78
glucose regulated protein 78
H2O2
hydrogen peroxide
Autophagy
IVD
IDD
NP
AF
MicroRNAs in osteosarcoma
期刊论文
Clinica Chimica Acta, 2015, 卷号: 444, 页码: 9-17
作者:
Zhang, Jian
;
Yan, Yi-Guo
;
Wang, Cheng
;
Zhang, Shu-Jun
;
Yu, Xiao-Hua*
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/12/27
OS
osteosarcoma
miRNAs
microRNAs
CSCs
cancer stem cells
RNA pol
RNA polymerase
DGCR8
DiGeorge syndrome critical gene 8
RISC
RNA-induced silencing complex
Exp 5
exportin 5
Ago
argonaute
MREs
miRNA recognition elements
APE1
apurinic/apyrimidinic endonuclease 1
MDM
murine double minute
TP53
tumor suppressor p53
mTOR
mammalian target of rapamycin
Eag1
ether à go-go 1
PI3K
phosphatidylinositol-3-kinase
PTEN
phosphatase and tensin homolog deleted on chromosome ten
Hsp90B1
heat shock protein 90B1
BMP2
bone morphogenetic protein 2
IGF1R
insulin-like growth factor 1 receptor
FAK
phospho-Akt and focal adhesion kinase
LPAATβ
lysophosphatidic acid acyltransferase β
HMGB1
high-mobility group box 1
FASN
fatty acid synthase
LZTS1
leucine zipper putative tumor suppressor 1
MMP
matrix metalloproteinase
LNA
locked nucleic acid
DATS
diallyl trisulfide
miRNAs
OS
TP53
Notch
Chemoresistance
HSP90 inhibitor AUY922 abrogates up-regulation of RTKs by mTOR inhibitor AZD8055 and potentiates its antiproliferative activity in human breast cancer
期刊论文
INTERNATIONAL JOURNAL OF CANCER, 2014, 卷号: 135, 期号: 10, 页码: 2462-2474
作者:
Chen, Si-Meng
;
Guo, Chen-Liang
;
Shi, Jia-Jie
;
Xu, Yi-Chao
;
Chen, Yi
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
mTOR kinase inhibitor
HSP90 inhibitor
breast cancer
receptor tyrosine kinases
drug combination
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