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海洋研究所 [8]
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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers
期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:
Lu, Xuxiu
;
Yu, Rilei
;
Li, Zhen
;
Yang, Mengke
;
Dai, Jiajia
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/04/07
Acquired resistance
Cancer
NSCLC
JC-010a
SHP2
Potential roles of MEK1 on aging in Argopecten scallops
期刊论文
FRONTIERS IN MARINE SCIENCE, 2022, 卷号: 9, 页码: 16
作者:
Yuan, Ke
;
Lu, Xia
;
Ning, Junhao
;
Chen, Min
;
Wang, Quanchao
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2023/08/17
bivalve
Argopecten scallops
MEK1
aging
nutrition restriction
The Role of Anti-EGFR Monoclonal Antibody in mCRC Maintenance Therapy
期刊论文
FRONTIERS IN MOLECULAR BIOSCIENCES, 2022, 卷号: 9
作者:
Yuan, Meiqin
;
Wang, Zeng
;
Lv, Wangxia
;
Pan, Hongming
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/05/16
mCRC
maintenance therapy
EGFR
monoclonal antibody
panitumumab
cetuximab
Cardiotoxicity of Epidermal Growth Factor Receptor 2-Targeted Drugs for Breast Cancer
期刊论文
FRONTIERS IN PHARMACOLOGY, 2021, 卷号: 12
作者:
Yang, ZiYan
;
Wang, Wei
;
Wang, Xiaojia
;
Qin, ZhiQuan
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2022/01/10
cardiotoxicity
ErbB2
targeting drugs
breast cancer
therapy
Application of Multigroup Technology in Non-Small-Cell Lung Cancer with Qi Stagnation and Blood Stasis Syndrome
期刊论文
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2021, 卷号: 2021
作者:
Ma, Guan-Jun
;
Qian, Xiang
;
Chen, Zhuo
;
Chen, Sha-Sha
;
Zhang, Ai-Qin
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/08/30
Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 218, 页码: 14
作者:
Yang, Xiangbo
;
Wang, Zhijia
;
Pei, Yuan
;
Song, Ning
;
Xu, Lei
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2021/08/17
SHP2 degradation
Proteolysis targeting chimera (PROTAC)
Thalidomide-based heterobifunctional molecules
E3 ubiquitin ligase
CRBN
Dual Mechanisms of Novel CD73-Targeted Antibody and Antibody-Drug Conjugate in Inhibiting Lung Tumor Growth and Promoting Antitumor Immune-Effector Function
期刊论文
MOLECULAR CANCER THERAPEUTICS, 2020, 卷号: 19, 期号: 11, 页码: 2340-2352
作者:
Jin, Rui
;
Liu, Liang
;
Xing, Yun
;
Meng, Tao
;
Ma, Lanping
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2020/12/24
Effect of Sediment Load Boundary Conditions in Predicting Sediment Delta of Tarbela Reservoir in Pakistan
期刊论文
WATER, 2019, 卷号: 11, 期号: 8, 页码: 20
作者:
Tarar, Zeeshan Riaz
;
Ahmad, Sajid Rashid
;
Ahmad, Iftikhar
;
ul Hasson, Shabeh
;
Khan, Zahid Mahmood
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  |  
浏览/下载:79/0
  |  
提交时间:2019/10/18
Upper Indus Basin (UIB)
Tarbela Reservoir
Besham Qila
sediment modeling
uncertainty
wavelet transform analysis-artificial neural network (WA-ANN)
sediment rating curve (SRC)
HEC-RAS
Effect of flow velocity on the growth, stress and immune responses of turbot (Scophthalmus maximus) in recirculating aquaculture systems
期刊论文
FISH & SHELLFISH IMMUNOLOGY, 2019, 卷号: 86, 页码: 1169-1176
作者:
Li, Xian
;
Ji, Liqin
;
Wu, Lele
;
Gao, Xiaolong
;
Li, Xueqin
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2019/05/15
Scophthalmus maximus
Flow velocity
Growth
Innate immune responses
Growth, immune response, antioxidant capability, and disease resistance of juvenile Atlantic salmon (Salmo salar L.) fed Bacillus velezensis V4 and Rhodotorula mucilaginosa compound
期刊论文
AQUACULTURE, 2019, 卷号: 500, 页码: 65-74
作者:
Wang, Chun
;
Liu, Ying
;
Sun, Guoxiang
;
Li, Xian
;
Liu, Zhipei
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2019/05/15
Antioxidant
Atlantic salmon
Bacillus velezensis V4
Growth
Immunity
Rhodotorula mucilaginosa
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