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cKMT1 is a New Lysine Methyltransferase That Methylates the Ferredoxin-NADP(+) Oxidoreductase and Regulates Energy Transfer in Cyanobacteria
期刊论文
MOLECULAR & CELLULAR PROTEOMICS, 2023, 卷号: 22, 期号: 4, 页码: 20
作者:
Cao, Gaoxiang
;
Lin, Xiaohuang
;
Ling, Mingtian
;
Lin, Jian
;
Zhang, Qi
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/05/07
Inhibition of the deubiquitinating enzyme USP47 as a novel targeted therapy for hematologic malignancies expressing mutant EZH2
期刊论文
LEUKEMIA, 2022
作者:
Yang, Jing
;
Weisberg, Ellen L.
;
Qi, Shuang
;
Ni, Wei
;
Mei, Husheng
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  |  
浏览/下载:76/0
  |  
提交时间:2022/02/14
5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 19
作者:
Wang, Shuni
;
Yang, Hong
;
Su, Mingbo
;
Lian, Fulin
;
Cong, Zhanqing
收藏
  |  
浏览/下载:80/0
  |  
提交时间:2021/11/04
NSD2
Methyltransferase
HTS
Multiple myeloma
5-Aminonaphthalene derivatives
Inhibitor
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 12, 页码: 8194-8207
作者:
Du, Daohai
;
Xu, Dandan
;
Zhu, Licheng
;
Stazi, Giulia
;
Zwergel, Clemens
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  |  
浏览/下载:74/0
  |  
提交时间:2021/08/17
Ube2b-dependent degradation of DNMT3a relieves a transcriptional brake on opiate-induced synaptic and behavioral plasticity
期刊论文
MOLECULAR PSYCHIATRY, 2021, 卷号: 26, 期号: 4, 页码: 1162-1177
作者:
Chen, Zhong-Guo
;
Wang, Yu-Jun
;
Chen, Ruo-Song
;
Geng, Fan
;
Gan, Chen-Ling
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  |  
浏览/下载:18/0
  |  
提交时间:2021/05/24
Synthesis and structure-activity relationship studies of LLY-507 analogues as SMYD2 inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 22, 页码: 5
作者:
Zhang, Bin
;
Liao, Liping
;
Wu, Fan
;
Zhang, Fengcai
;
Sun, Zhongya
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/05/24
SMYD2 inhibitors
Thermal shift assay
Structure-activity relationships
The cross-talk between methylation and phosphorylation in lymphoid-specific helicase drives cancer stem-like properties
期刊论文
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2020, 卷号: 5, 期号: 1, 页码: 14
作者:
Liu, Na
;
Yang, Rui
;
Shi, Ying
;
Chen, Ling
;
Liu, Yating
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  |  
浏览/下载:34/0
  |  
提交时间:2020/12/21
Identification of catalytic and non-catalytic activity inhibitors against PRC2-EZH2 complex through multiple high-throughput screening campaigns
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2020, 页码: 27
作者:
Zhou, Yan
;
Du, Dao-Hai
;
Wang, Jia
;
Cai, Xiao-Qing
;
Deng, Alicia X.
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  |  
浏览/下载:102/0
  |  
提交时间:2020/07/01
embryonic ectoderm development
Enhancer of zeste homolog 2
fluorescence polarization
high-throughput screening
homogenous time-resolved fluorescence
inhibitor
polycomb repressive complex 2
Lead discovery, chemical optimization, and biological evaluation studies of novel histone methyltransferase SET7 small-molecule inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 9, 页码: 10
作者:
Hou, Zeng
;
Min, Wenjian
;
Zhang, Rukang
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2020/07/01
Histone methylation
SET7
Small-molecule inhibitor
Virtual screening
Molecular probe
Computational discovery and biological evaluation of novel inhibitors targeting histone-lysine N-methyltransferase SET7
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2020, 卷号: 28, 期号: 7, 页码: 10
作者:
Min, Wenjian
;
Hou, Zeng
;
Zhang, Fang
;
Xie, Shengnan
;
Yuan, Kai
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2020/07/01
Histone methylation
Lysine methyltransferase
SET7
Small-molecule inhibitor
Virtual screening
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