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科研机构
山东大学 [5]
上海药物研究所 [2]
大连化学物理研究所 [2]
复旦大学上海医学院 [2]
兰州大学 [1]
心理研究所 [1]
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期刊论文 [16]
专利 [1]
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2018 [2]
2017 [1]
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2014 [2]
2012 [3]
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Lonafarnib synergizes with azoles against Aspergillus spp. and Exophiala spp.
期刊论文
MEDICAL MYCOLOGY, 2018, 卷号: 56, 期号: 4
作者:
Qiao, Jianjun
;
Sun, Yi
;
Gao, Lujuan
;
He, Chengyan
;
Zheng, Wenqian
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
lonafarnib
farnesyltransferase inhibitor
azoles
Aspergillus
Exophiala
Systemic or Forebrain Neuron-Specific Deficiency of Geranylgeranyltransferase-1 Impairs Synaptic Plasticity and Reduces Dendritic Spine Density
期刊论文
Neuroscience, 2018, 卷号: 373, 页码: 207-217
作者:
Hottman, David
;
Cheng, Shaowu(成绍武)
;
Gram, Andrea
;
LeBlanc, Kyle
;
Yuan, Li-Lian
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/27
ALS
amyotrophic lateral sclerosis
aCSF
artificial cerebrospinal fluid
AD
Alzheimer’s disease
ANOVA
analysis of variance
AO
apical oblique
BS
basal shaft
CaMKII α
Ca2+/calmodulin-dependent protein kinase
CNS
central nervous system
Cre+
Cre recombinase transgene positive
fEPSPs
field excitatory post-synaptic potentials
FPP
farnesyl pyrophosphate
FT
farnesyltransferase
GAPDH
glyceraldehyde-3-phosphate dehydrogenase
GGPP
geranylgeranyl pyrophosphate
GGT
geranylgeranyltransferase-1
GGT+/−
GGT-haplodeficient
GGTf/f
GGT gene floxed
GGTf/fCre+
conditional forebrain neuron-specific GGT knockout
GTP
guanosine triphosphate
I/O
input/output
LTP
long-term potentiation
PPF
paired-pulse facilitation
WT
wild type
protein prenylation
geranylgeranyltransferase
knockout mouse models
small GTPases
synaptic plasticity
dendritic spine density
The discovery of a novel compound with potent antitumor activity: virtual screening, synthesis, biological evaluation and preliminary mechanism study
期刊论文
2017, 卷号: 8, 期号: 15, 页码: 24635-24643
作者:
Jin Yuanyuan
;
Li Linhu
;
Yang Zhaoyong
;
Liu Mingliang
;
Guo Huiyuan
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/01/04
anti-tumor
synthesis
virtual screening
farnesyltransferase inhibitor
Absence of Protoheme IX Farnesyltransferase CtaB Causes Virulence Attenuation but Enhances Pigment Production and Persister Survival in MRSA
期刊论文
FRONTIERS IN MICROBIOLOGY, 2016, 卷号: 7
作者:
Xu, T
;
Han, J
;
Zhang, J
;
Chen, J
;
Wu, N
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2017/05/08
Staphylococcus aureus
heme
antibiotics
pigment
virulence
persister formation
Absence of Protoheme IX Farnesyltransferase CtaB Causes Virulence Attenuation but Enhances Pigment Production and Persister Survival in MRSA
期刊论文
FRONTIERS IN MICROBIOLOGY, 2016, 卷号: 7
作者:
Xu, Tao
;
Han, Jian
;
Zhang, Jia
;
Chen, Jiazhen
;
Wu, Nan
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/13
Staphylococcus aureus
heme
antibiotics
pigment
virulence
persister formation
The Recent Development of Farnesyltransferase Inhibitors as Anticancer and Antimalarial Agents
期刊论文
Mini reviews in medicinal chemistry, 2015, 卷号: 15, 期号: 10, 页码: 837-857
作者:
Shen, Yan
;
Qiang, Shengsheng
;
Ma, Shutao
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  |  
浏览/下载:3/0
  |  
提交时间:2019/12/17
Anticancer
antimalaria
farnesyltransferase
FTase inhibitors
FTase inhibitory activity
selectivity
Ras-induced Epigenetic Inactivation of the RRAD ( Ras-related Associated with Diabetes) Gene Promotes Glucose Uptake in a Human Ovarian Cancer Model
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 卷号: 289, 期号: 20, 页码: 14225-14238
作者:
Wang, Yan
;
Li, Guiling
;
Mao, Fengbiao
;
Li, Xianfeng
;
Liu, Qi
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2015/09/09
DNA Methylation
Metabolism
Ovarian Cancer
Ras
Tumor Suppressor Gene
Oncogenic Transformation
RRAD
Deracemization of 2-Methyl-1,2,3,4-Tetrahydroquinoline Using Mutant Cyclohexylamine Oxidase Obtained by Iterative Saturation Mutagenesis
期刊论文
ACS CATALYSIS, 2014, 卷号: 4, 期号: 3, 页码: 903-908
作者:
Li, Guangyue
;
Ren, Jie
;
Yao, Peiyuan
;
Duan, Yitao
;
Zhang, Hailing
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2016/06/23
biocatalysis
amine oxidase
iterative saturation mutagenesis
chiral amines
deracemization
Expression of farnesyltransferase in primary liver cancer
期刊论文
CHINESE MEDICAL JOURNAL, 2012, 卷号: 125, 期号: 14, 页码: 2427-2431
作者:
Sui Guo-de
;
Zhang Guang-yong
;
Niu Zhao-jian
;
Hu San-yuan
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/23
primary liver cancer
farnesyltransferase
fluorescent
quantitative-polymerase chain reaction
Expression of farnesyltransferase in primary liver cancer
期刊论文
中华医学杂志:英文版, 2012, 期号: 14
作者:
SUI Guo-de ZHANG Guang-yong NIU Zhao-jian HU San-yuan[1]
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/23
原发性肝癌
转移酶
MRNA表达水平
荧光定量聚合酶链反应
恶性肿瘤
PLC
肝组织
可靠指标
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