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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers
期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:
Lu, Xuxiu
;
Yu, Rilei
;
Li, Zhen
;
Yang, Mengke
;
Dai, Jiajia
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/04/07
Acquired resistance
Cancer
NSCLC
JC-010a
SHP2
Insights into intercellular receptor-ligand binding kinetics in cell communication
期刊论文
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2022, 卷号: 10, 页码: 953353
作者:
An, Chenyi
;
Wang, Xiaohuan
;
Song F(宋凡)
;
Hu, Jinglei
;
Li L(李龙)
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2022/10/23
cell communication
intercellular receptor-ligand binding kinetics
protein-membrane interaction
biomechanical force
bioelectric microenvironment
DNA damage-induced translocation of mitochondrial factor HIGD1A into the nucleus regulates homologous recombination and radio/chemo-sensitivity
期刊论文
ONCOGENE, 2022
作者:
Chen, Bin
;
Xu, Feng
;
Gao, Yang
;
Hu, Guanshuo
;
Zhu, Kaili
收藏
  |  
浏览/下载:67/0
  |  
提交时间:2022/03/21
Integrated Transcriptomics and Reverse Pharmacophore Mapping-based Network Pharmacology to Explore the Mechanisms of Natural Compounds against Doxorubicin-induced Cardiotoxicity
期刊论文
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 2022, 卷号: 25
作者:
Zhu, Junfeng
;
Yi, Xiaojiao
;
Ding, Haiying
;
Zhong, Like
;
Fang, Luo
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2022/12/22
Doxorubicin-induced cardiotoxicity
natural compounds
mechanism of action
gene expression profile
bioinformatics
network pharmacology
Site-specific protein modification by 3-n-butylphthalide in primary hepatocytes: Covalent protein adducts diminished by glutathione and N-acetylcysteine
期刊论文
LIFE SCIENCES, 2021, 卷号: 287, 页码: 14
作者:
Xue, Yaru
;
Ren, Xuelian
;
Zhu, Zhengdan
;
Lei, Peng
;
Liu, Mengling
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/01/18
3-n-butylphthalide
Hepatotoxicity
Oxidative stresses
Covalent protein modification
Drug-drug interaction
Transformer-Based Generative Model Accelerating the Development of Novel BRAF Inhibitors
期刊论文
ACS OMEGA, 2021, 卷号: 6, 期号: 49, 页码: 33864-33873
作者:
Yang, Lijuan
;
Yang, Guanghui
;
Bing, Zhitong
;
Tian, Yuan
;
Niu, Yuzhen
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2022/04/11
Picture-word order compound protein interaction: Predicting compound-protein interaction using structural images of compounds
期刊论文
JOURNAL OF COMPUTATIONAL CHEMISTRY, 2021, 页码: 10
作者:
Qian, Ying
;
Li, Xuelian
;
Wu, Jian
;
Zhou, Aimin
;
Xu, Zhijian
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/01/04
compound-protein interaction
convolutional neural network (CNN)
drug-drug interaction
image processing
structural images
Structural characteristics of Heparan sulfate required for the binding with the virus processing Enzyme Furin
期刊论文
GLYCOCONJUGATE JOURNAL, 2021, 页码: 11
作者:
Zeng, Jiaxin
;
Meng, Yuan
;
Chen, Shi-Yi
;
Zhao, Gaofeng
;
Wang, Lianchun
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2021/12/01
Furin
Heparan sulfate
Heparin
Virus infection
Carbohydrate-protein interaction
Insights into agonist-elicited activation of the human glucose-dependent insulinotropic polypeptide receptor
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2021, 卷号: 192, 页码: 16
作者:
Yuliantie, Elita
;
van der Velden, Wijnand J. C.
;
Labroska, Viktorija
;
Dai, Antao
;
Zhao, Fenghui
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2021/11/04
Glucose-dependent insulinotropic polypeptide receptor
G protein-coupled receptor
GPCR structure-function relationship
ERK
cAMP
Arrestin
Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor
期刊论文
CELL RESEARCH, 2021, 页码: 11
作者:
Ma, Shanshan
;
Chen, Yan
;
Dai, Antao
;
Yin, Wanchao
;
Guo, Jia
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2021/11/04
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