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Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design
期刊论文
NATURE COMMUNICATIONS, 2021, 卷号: 12, 期号: 1, 页码: 15
作者:
Lu, Shaoyong
;
He, Xinheng
;
Yang, Zhao
;
Chai, Zongtao
;
Zhou, Shuhua
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2021/11/04
Systematic characterization of AT1 receptor antagonists with label-free dynamic mass redistribution assays
期刊论文
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2020, 卷号: 102
作者:
Qu, Lala
;
Wang, Jixia
;
Hou, Tao
;
Zhou, Han
;
Wang, Zhiwei
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  |  
浏览/下载:19/0
  |  
提交时间:2020/11/25
Angiotensin II type 1 receptor
Antagonist
Binding property
Dynamic mass redistribution assay
Upregulation of AT(1) Receptor Mediates a Pressor Effect Through ROS-SAPK/JNK Signaling in Glutamatergic Neurons of Rostral Ventrolateral Medulla in Rats With stress-Induced Hypertension
期刊论文
FRONTIERS IN PHYSIOLOGY, 2019, 卷号: 9
作者:
Jiang, Liping
;
Zhou, Xuan
;
Yang, Hongyu
;
Guan, Ruijuan
;
Xin, Yanlei
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  |  
浏览/下载:29/0
  |  
提交时间:2019/12/05
angiotensin II type 1 receptor
stress-induced hypertension
glutamatergic neurons
rostral ventrolateral medulla
NAPDH oxidase-ROS-SAPK/JNK signaling
Central blockade of the AT1 receptor attenuates pressor effects via reduction of glutamate release and downregulation of NMDA/AMPA receptors in the rostral ventrolateral medulla of rats with stress-induced hypertension
期刊论文
HYPERTENSION RESEARCH, 2019, 卷号: 42, 期号: 8
作者:
Song, Xiaoshan
;
Wang, Jijiang
;
Wang, Jin
;
Shen, Linlin
;
Zhou, Xuan
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  |  
浏览/下载:29/0
  |  
提交时间:2019/12/05
Angiotensin II type 1 receptor
NMDA/AMPA receptor
Glutamatergic neurons
Rostral ventrolateral medulla
Stress-induced hypertension
Candesartan inhibits inflammation through an angiotensin II type 1 receptor independent way in human embryonic kidney epithelial cells
期刊论文
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS, 2019, 卷号: 91, 期号: 2
作者:
Yu, Ying
;
Jiang, Haifeng
;
Niu, Yangyang
;
Zhang, Xiaoqin
;
Zhang, Yingying
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  |  
浏览/下载:10/0
  |  
提交时间:2019/12/05
Angiotensin II type 1 receptor blockers
candesartan
inflammation
reactive oxygen species
Telmisartan attenuates diabetic nephropathy progression by inhibiting the dimerization of angiotensin type-1 receptor and adiponectin receptor-1
期刊论文
LIFE SCIENCES, 2019, 卷号: 221
作者:
Zha, Dongqing
;
Yao, Tao
;
Bao, Liping
;
Gao, Ping
;
Wu, Xiaoyan
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  |  
浏览/下载:2/0
  |  
提交时间:2019/12/05
Telmisartan
Angiotensin II type 1 receptor
Adiponectin receptor 1
Diabetic nephropathy
Heterodimerization
Decreased H3K9ac level of AT2R mediates the developmental origin of glomerulosclerosis induced by prenatal dexamethasone exposure in male offspring rats
期刊论文
TOXICOLOGY, 2019, 卷号: 411
作者:
Li, Bin
;
Zhu, Yanan
;
Chen, Haiyun
;
Gao, Hui
;
He, Hangyuan
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  |  
浏览/下载:11/0
  |  
提交时间:2019/12/05
Prenatal dexamethasone exposure
Glomerulosclerosis
Kidney development
Angiotensin II receptor type 2 (AT2R)
Intrauterine programming
Histone acetylation
Association of angiotensin II type 1 receptor gene A1166C polymorphism with cancer risk: An updated meta-analysis
期刊论文
JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 2019, 卷号: Vol.20 No.1, 页码: 1-7
作者:
Hu, Xue
;
Chen, Jing
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  |  
浏览/下载:11/0
  |  
提交时间:2019/12/13
Angiotensin
polymorphism
meta-analysis
cancer
Exposure to diisononyl phthalate induced an increase in blood pressure through activation of the ACE/ AT1R axis and inhibition of NO production.
期刊论文
Toxicology letters, 2019, 卷号: 309, 页码: 42-50
作者:
Deng, Ting
;
Xie, Xiaoman
;
Duan, Jiufei
;
Chen, Mingqing*
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  |  
浏览/下载:34/0
  |  
提交时间:2019/12/23
Angiotensin converting enzyme
Angiotensin-II- type 1 receptor
Blood pressure
Diisononyl phthalate
Endothelial nitric oxide synthase
Single-molecule force spectroscopy study of interactions between angiotensin II type 1 receptor and different biased ligands in living cells
期刊论文
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2018, 卷号: 410, 期号: 14, 页码: 3275-3284
作者:
Li, Wenhui
;
Xu, Jiachao
;
Kou, Xiaolong
;
Zhao, Rong
;
Zhou, Wei
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/04/09
Angiotensin Ii Type 1 Receptor
Biased Ligands
Atomic Force Microscopy
Single-molecule Force Spectroscopy
Energy Landscape
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