CORC

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CORC

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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers 期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:  Lu, Xuxiu;  Yu, Rilei;  Li, Zhen;  Yang, Mengke;  Dai, Jiajia
收藏  |  浏览/下载：5/0  |  提交时间：2024/04/07
Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy 期刊论文
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13
作者:  Hua, Chen;  Shena, Lijuan;  Zoua, Fengming;  Wua, Yun;  Wanga, Beilei
收藏  |  浏览/下载：12/0  |  提交时间：2023/11/10
Targeting KRAS mutant cancers: from druggable therapy to drug resistance 期刊论文
MOLECULAR CANCER, 2022, 卷号: 21
作者:  Zhu, Chunxiao;  Guan, Xiaoqing;  Zhang, Xinuo;  Luan, Xin;  Song, Zhengbo
收藏  |  浏览/下载：24/0  |  提交时间：2022/12/23
CHMFL-26 is a highly potent irreversible HER2 inhibitor for use in the treatment of HER2-positive and HER2-mutant cancers 期刊论文
ACTA PHARMACOLOGICA SINICA, 2022
作者:  Cao, Jiang-yan;  Qi, Shuang;  Wu, Hong;  Wang, Ao-li;  Liu, Qing-wang
收藏  |  浏览/下载：93/0  |  提交时间：2022/03/28
LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo 期刊论文
CANCER SCIENCE, 2021, 页码: 12
作者:  Liu, Yingqiang;  Lai, Mengzhen;  Li, Shan;  Wang, Yanan;  Feng, Fang
收藏  |  浏览/下载：62/0  |  提交时间：2022/01/18
Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: The Multi-Targeting Drug DREAM Challenge 期刊论文
PLOS COMPUTATIONAL BIOLOGY, 2021, 卷号: 17, 期号: 9, 页码: 19
作者:  Xiong, Zhaoping;  Jeon, Minji
收藏  |  浏览/下载：22/0  |  提交时间：2021/11/04
Itraconazole and rifampicin, as CYP3A modulators but not P-gp modulators, affect the pharmacokinetics of almonertinib and active metabolite HAS-719 in healthy volunteers 期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:  Liu, Lu;  Li, Wei;  Yang, Le;  Guo, Zi-tao;  Xue, Hao
收藏  |  浏览/下载：78/0  |  提交时间：2021/08/17
Discovery of a highly potent kinase inhibitor capable of overcoming multiple imatinib-resistant ABL mutants for chronic myeloid leukemia (CML) 期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2021, 卷号: 897
作者:  Lu, Tingting;  Cao, Jiangyan;  Zou, Fengming;  Li, Xixiang;  Wang, Aoli
收藏  |  浏览/下载：42/0  |  提交时间：2021/04/26
Adaptive resistance to PI3K alpha-selective inhibitor CYH33 is mediated by genomic and transcriptomic alterations in ESCC cells 期刊论文
CELL DEATH & DISEASE, 2021, 卷号: 12, 期号: 1, 页码: 13
作者:  Wang, Yu-xiang;  Zhang, Xu;  Ma, Qing-yang;  Hu, Lan-dian;  Zhang, Xi
收藏  |  浏览/下载：48/0  |  提交时间：2021/05/24
SAF-189s, a potent new-generation ROS1 inhibitor, is active against crizotinib-resistant ROS1 mutant-driven tumors 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 7
作者:  Xia, Zong-jun;  Ji, Yin-chun;  Sun, De-qiao;  Peng, Xia;  Gao, Ying-lei
收藏  |  浏览/下载：78/0  |  提交时间：2020/12/21

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