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上海药物研究所 [24]
复旦大学上海医学院 [3]
合肥物质科学研究院 [3]
厦门大学 [1]
中国科学院大学 [1]
海洋研究所 [1]
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期刊论文 [37]
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The reversal of anti-HER2 resistance in advanced HER2-positive breast cancer using apatinib: two cases reports and literature review
期刊论文
TRANSLATIONAL CANCER RESEARCH, 2022
作者:
He, Libin
;
Shen, Xiabo
;
Liu, Yiyuan
;
Gao, Lu
;
Wu, Jiayi
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/12/23
Advanced human epidermal growth factor receptor 2-positive breast cancer (advanced HER2-positive breast cancer)
apatinib
case report
Discovery of a highly selective VEGFR2 kinase inhibitor CHMFL-VEGFR2-002 as a novel anti-angiogenesis agent
期刊论文
ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10
作者:
Jiang, Zongru
;
Wang, Li
;
Liu, Xuesong
;
Chen, Cheng
;
Wang, Beilei
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/11/26
Cancer
VEGFR2 kinase
Kinase inhibitor
Angiogenesis
Inhibitor selectivity
Exploring binding mechanisms of VEGFR2 with three drugs lenvatinib, sorafenib, and sunitinib by molecular dynamics simulation and free energy calculation
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 卷号: 93, 期号: 5, 页码: 934-948
作者:
Wang, Yu
;
Peng, Cheng
;
Wang, Guimin
;
Xu, Zhijian
;
Luo, Yongfeng
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
hydrophobic contact scanning
MM
GBSA
molecular dynamics simulation
VEGFR2-drugs interaction
Discovery of Potent Irreversible Pan-Fibroblast Growth Factor Receptor (FGFR) Inhibitors
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 20, 页码: 9085-9104
作者:
Wang, Yuming
;
Li, Lijun
;
Fan, Jun
;
Dai, Yang
;
Jiang, Alan
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
Design, synthesis and biological evaluation of a series of novel 2-benzamide-4-(6-oxy-N-methyl-l-naphthamide)-pyridine derivatives as potent fibroblast growth factor receptor (FGFR) inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 154, 页码: 9-28
作者:
Wei, Manman
;
Peng, Xia
;
Xing, Li
;
Dai, Yang
;
Huang, Ruimin
收藏
  |  
浏览/下载:63/0
  |  
提交时间:2019/01/08
FGFR
VEGFR
Synergistic effect
Tumor growth inhibition
Lucitanib
Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFR alpha kinase inhibitor for PDGFR alpha driving chronic eosinophilic leukemia
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 150, 期号: 无, 页码: 366-384
作者:
Wang, Qiang
;
Liu, Feiyang
;
Qi, Shuang
;
Qi, Ziping
;
Yan, Xiao-E.
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  |  
浏览/下载:62/0
  |  
提交时间:2019/06/10
PDGFR kinase
Type II inhibitor
Kinase inhibitor
CEL
PBA2 exhibits potent anti-tumor activity via suppression of VEGFR2 mediated-cell proliferation and angiogenesis
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2018, 卷号: 150, 页码: 131-140
作者:
Fang, Xiaona
;
Xie, Hua
;
Luo, Min
;
Chen, Zhen
;
Wang, Fang
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  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
Angiogenesis
And-tumor activity
Multi-tyrosine kinases inhibitor
PBA2
VEGFR2
Preclinical characterization of anlotinib, a highly potent and selective vascular endothelial growth factor receptor-2 inhibitor
期刊论文
CANCER SCIENCE, 2018, 卷号: 109, 期号: 4, 页码: 1207-1219
作者:
Xie, Chengying
;
Wan, Xiaozhe
;
Quan, Haitian
;
Zheng, Mingyue
;
Fu, Li
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/01/08
angiogenesis
anlotinib
tyrosine kinase inhibitor
VEGF
VEGFR2
Chlorogenic acid attenuates diabetic retinopathy by reducing VEGF expression and inhibiting VEGF-mediated retinal neoangiogenesis
期刊论文
Vascular pharmacology, 2018, 卷号: 101, 页码: 29-37
作者:
Mei, Xiyu
;
Zhou, Lingyu
;
Zhang, Tianyu
;
Lu, Bin
;
Sheng, Yuchen
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2019/01/08
Dioscin suppresses the viability of ovarian cancer cells by regulating the VEGFR2 and PI3K/AKT/MAPK signaling pathways
期刊论文
ONCOLOGY LETTERS, 2018, 卷号: 15, 期号: 6, 页码: 9537-9542
作者:
Guo, Xianqing
;
Ding, Xiao
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/11
dioscin
ovarian cancer cells
vascular endothelial growth factor
receptor 2
phosphoinositide 3-kinase/protein kinase B
mitogen-activated protein kinase
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