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上海药物研究所 [22]
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湖南大学 [2]
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期刊论文 [31]
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Rapid re-evaluation of bioactive saponins from Paris polyphylla using affinity ultrafiltration-LC/MS with multiple drug targets
期刊论文
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 2018, 卷号: 434, 页码: 87-92
作者:
Guo, Mingquan
;
Chen, Guilin
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浏览/下载:58/0
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提交时间:2018/12/29
Ultrafiltration-LC/MS
Polyphyllin
Topoisomerase I and II
Cyclooxygenase 2
Multiple drug targets
Synthesis and In Vitro Antitumor Activity of Novel Bivalent -Carboline-3-carboxylic Acid Derivatives with DNA as a Potential Target
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 卷号: 19, 期号: 10
作者:
Gu, Hongling
;
Li, Na
;
Dai, Jiangkun
;
Xi, Yaxi
;
Wang, Shijun
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  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
bivalent -carbolines
antitumor
apoptosis
DNA-binding affinity
bcl-2
New tanshinone I derivatives S222 and S439 similarly inhibit topoisomerase I/II but reveal different p53-dependency in inducing G2/M arrest and apoptosis
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2018, 卷号: 154, 页码: 255-264
作者:
Tian, Qian-Ting
;
Ding, Chun-Yong
;
Song, Shan-Shan
;
Wang, Ying-Qing
;
Zhang, Ao
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  |  
浏览/下载:40/0
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提交时间:2019/01/08
Tanshinone-1
S222
S439
Anticancer targets
DNA topoisomerases
P53
Molecular Determinants of the Anticancer Efficacy of Topoisomerase I Inhibitors
会议论文
MMHS-2015, Shanghai, China
作者:
Fung-Ming Siu
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浏览/下载:12/0
  |  
提交时间:2016/01/27
Design and synthesis of 2-phenylnaphthalenoids and 2-phenylbenzofuranoids as DNA topoisomerase inhibitors and antitumor agents
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 卷号: 102, 页码: 277-287
作者:
Hao, Huilin
;
Chen, Wang
;
Zhu, Jing
;
Lu, Chunhua
;
Shen, Yuemao
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  |  
浏览/下载:2/0
  |  
提交时间:2019/12/17
2-Phenylnaphthalenoids
2-Phenylbenzofuranoids
Topoisomerase II alpha
inhibitor
Antitumor
DNA Interaction, Photocleavage and Topoisomerase I Inhibition by Ru Complex with a New Ligand Possessing Phenazine Unit.
期刊论文
JOURNAL OF FLUORESCENCE, 2015, 卷号: Vol.25 No.5, 页码: 1527-1535
作者:
Liu, Xue-Wen
;
Shen, You-Ming
;
Shu, Jun-Shi
;
Xiao, Yang
;
Zhang, Song-Bai
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浏览/下载:3/0
  |  
提交时间:2019/12/31
Ru(II)
complex
DNA-binding
Photocleavage
Topoisomerase
inhibition
G226, a new epipolythiodioxopiperazine derivative, triggers DNA damage and apoptosis in human cancer cells in vitro via ROS generation
期刊论文
ACTA PHARMACOLOGICA SINICA, 2014, 卷号: 35, 期号: 12, 页码: 1546-1555
作者:
He, Peng-xing
;
Zhang, Jie
;
Che, Yong-sheng
;
He, Qiao-jun
;
Chen, Yi
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  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
G226
epipolythiodioxopiperazine
11 '-deoxyverticillin A
anti-cancer agent
Topo II
DNA damage
apoptosis
ROS
antioxidant
DNA Topoisomerase II Is Dispensable for Oocyte Meiotic Resumption but Is Essential for Meiotic Chromosome Condensation and Separation in Mice
期刊论文
http://dx.doi.org/10.1095/biolreprod.113.110692, 2013
Li, Xiao-Meng
;
Yu, Chao
;
Wang, Zhong-Wei
;
Zhang, Yin-Li
;
Liu, Xiao-Man
;
Zhou, Dawang
;
Sun, Qing-Yuan
;
Fan, Heng-Yu
;
周大旺
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2015/07/22
EMBRYONIC STEM-CELLS
DECATENATION CHECKPOINT
MAMMALIAN OOCYTES
CYCLE CHECKPOINT
CHROMATIN
DAMAGE
ALPHA
MICROTUBULES
MATURATION
SURVIVIN
Ruthenium (II) complexes containing a new asymmetric ligand: DNA interaction, photocleavage and topoisomerase I inhibition
期刊论文
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2013, 卷号: Vol.729, 页码: 1-8
作者:
Liu, Xue-Wen
;
Zhang, Song-Bai
;
Li, Lin
;
Chen, Yuan-Dao
;
Lu, Ji-Lin
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/01/05
Natural Product Triptolide Mediates Cancer Cell Death by Triggering CDK7-Dependent Degradation of RNA Polymerase II
期刊论文
CANCER RESEARCH, 2012, 卷号: 72, 期号: 20, 页码: 5363-5373
作者:
Manzo, Stefano Giustino
;
Zhou, Zhao-Li
;
Wang, Ying-Qing
;
Marinello, Jessica
;
He, Jin-Xue
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  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
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