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上海药物研究所 [17]
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期刊论文 [28]
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GM-Pep: A High Efficiency Strategy to De Novo Design Functional Peptide Sequences
期刊论文
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2022, 卷号: 62, 期号: 10, 页码: 2617-2629
作者:
Chen, Qushuo
;
Yang, Changyan
;
Xie, Yihao
;
Wang, Yuqiang
;
Li, Xiaoxu
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2022/06/21
BioactivityDrug interactionsLearning systemsToxicity
Auto encodersComputation methodsDe novo designFunctional peptidesHigher efficiencyMulti-classifierPeptide sequencesPeptide therapeuticsTherapeutic agentsTherapeutic peptides
Define Mesenchymal Stem Cell from Its Fate: Biodisposition of Human Mesenchymal Stem Cells in Normal and Concanavalin A-Induced Liver Injury Mice
期刊论文
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2021, 卷号: 379, 期号: 2, 页码: 125-133
作者:
Han, Li
;
Ma, Chenhui
;
Peng, Huige
;
Wu, Zhitao
;
Xu, Huiming
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  |  
浏览/下载:25/0
  |  
提交时间:2022/01/04
Discovery of a Pyrimidinedione Derivative as a Potent and Orally Bioavailable Axl Inhibitor
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 7, 页码: 3956-3975
作者:
Zhang, Hefeng
;
Peng, Xia
;
Dai, Yang
;
Shao, Jingwei
;
Ji, Yinchun
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  |  
浏览/下载:16/0
  |  
提交时间:2021/06/11
Design, Synthesis, and Biological Evaluation of Orally Bioavailable CHK1 Inhibitors Active against Acute Myeloid Leukemia
期刊论文
CHEMMEDCHEM, 2021, 页码: 12
作者:
Jin, Tingting
;
Wang, Peipei
;
Long, Xiubing
;
Jiang, Kailong
;
Song, Pinrao
收藏
  |  
浏览/下载:133/0
  |  
提交时间:2021/05/24
CHK1 inhibitor
diaminopyrimidine
DNA damage response
oral bioavailability
Evaluation of biased agonism mediated by dual agonists of the GLP-1 and glucagon receptors
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 180, 页码: 16
作者:
Darbalaei, Sanaz
;
Yuliantie, Elita
;
Dai, Antao
;
Chang, Rulue
;
Zhao, Peishen
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  |  
浏览/下载:19/0
  |  
提交时间:2020/12/21
G protein-coupled receptor
Glucagon-like peptide-1 receptor
Glucagon receptor
Biased agonism
Unimolecular dual agonist
Advances in the development of imaging probes and aggregation inhibitors for alpha-synuclein
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 4, 页码: 483-498
作者:
Xu, Ming-ming
;
Ryan, Philip
;
Rudrawar, Santosh
;
Quinn, Ronald J.
;
Zhang, Hai-yan
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  |  
浏览/下载:26/0
  |  
提交时间:2020/07/01
Parkinson's disease
alpha-synuclein
imaging probes
aggregation inhibitors
thioflavin-T
mass spectrometry
Multifunctional Nanoparticles in Precise Cancer Treatment: Considerations in Design and Functionalization of Nanocarriers
期刊论文
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2020, 卷号: 20, 期号: 27, 页码: 2427-2441
作者:
Lu, Lina
;
Kang, Shuhe
;
Sun, Chao
;
Sun, Chufeng
;
Guo, Zhong
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  |  
浏览/下载:15/0
  |  
提交时间:2021/12/10
Nanoparticles
Targeted cancer treatment
Physiochemical characteristics
Targeting strategies
Clinical applications
Toxicity
Cholesterol-tuned liposomal membrane rigidity directs tumor penetration and anti-tumor effect
期刊论文
Acta Pharmaceutica Sinica B, 2019, 卷号: 9, 期号: 4, 页码: 858-870
作者:
Wu Hangyi
;
Yu Miaorong
;
Miao Yunqiu
;
He Shufang
;
Dai Zhuo
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2021/02/02
Therapeutics. Pharmacology
RM1-950
Recent progress in drug delivery
期刊论文
Acta Pharmaceutica Sinica B, 2019, 卷号: 9, 期号: 6, 页码: 1145-1162
作者:
Li Chong
;
Wang Jiancheng
;
Wang Yiguang
;
Gao Huile
;
Wei Gang
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2021/02/02
Therapeutics. Pharmacology
RM1-950
Novel C-17 spirost protostane-type triterpenoids from Alismaplantago-aquaticawith anti-inflammatory activity inCaco-2cells
期刊论文
Acta Pharmaceutica Sinica B, 2019, 卷号: 9, 期号: 4, 页码: 809
作者:
Qinghao Jin
;
Jianqing Zhang
;
Jinjun Hou
;
Min Lei
;
Chen Liu
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/12/24
Therapeutics. Pharmacology
RM1-950
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