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中国医学科学院 北... [10]
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期刊论文 [31]
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Liquid chromatography-tandem mass spectrometric assay for TPN171 in human plasma
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2020, 卷号: 191, 页码: 8
作者:
Zhang, Mengqi
;
Liu, Haiming
;
He, Jiajin
;
Gui, Yuzhou
;
Qian, Hongjie
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/12/24
TPN171
LC-MS/MS
Human plasma
Protein precipitation
Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:
Wang, Zhen
;
Jiang, Xiangrui
;
Zhang, Xianglei
;
Tian, Guanghui
;
Yang, Rulei
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2020/07/01
Evaluation of the long-term safety and effectiveness of tadalafil once daily in Chinese men with erectile dysfunction: interim results of a multicenter, randomized, open-label trial
期刊论文
BJU INTERNATIONAL, 2019, 卷号: 123
作者:
Lou, Y.
;
Luo, J.
;
Hui, J.
;
Zhao, L.
;
Lin, H.
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
Enhancement of the apparent solubility and bioavailability of Tadalafil nanoparticles via antisolvent precipitation
期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 卷号: Vol.128, 页码: 222-231
作者:
Rao, Qiuhong
;
Qiu, Zhenwen
;
Huang, Deen
;
Lu, Tiejun
;
Zhang, Zhenyu Jason
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2019/12/13
Tadalafil
Antisolvent precipitation
Amorphous solid dispersion
Apparent solubility
Bioavailability
Enhancement of the apparent solubility and bioavailability of Tadalafil nanoparticles via antisolvent precipitation
期刊论文
European Journal of Pharmaceutical Sciences, 2019, 卷号: Vol.128, 页码: 222-231
作者:
Qiuhong Rao
;
Zhenwen Qiu
;
Deen Huang
;
Tiejun Lu
;
Zhenyu Jason Zhang
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2019/12/13
Tadalafil
Antisolvent
precipitation
Amorphous
solid
dispersion
Apparent
solubility
Bioavailability
Efficacy and safety of tadalafil 5 mg once-daily in Asian men with both lower urinary tract symptoms associated with benign prostatic hyperplasia and erectile dysfunction: A phase 3, randomized, double-blind, parallel, placebo- and tamsulosin-con
期刊论文
2019, 卷号: 26, 期号: 2, 页码: 192-200
作者:
Zhang, Zhichao
;
Li, Hanzhong
;
Zhang, Xiaodong
;
Dai, Yutian
;
Park, Hyun Jun
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/01/03
Asia
erectile dysfunction
lower urinary tract symptoms
prostatic hyperplasia
tadalafil
Evaluation of the long-term safety and effectiveness of tadalafil once daily in Chinese men with erectile dysfunction: interim results of a multicenter, randomized, open-label trial
会议论文
BJU INTERNATIONAL, 2019-04-01
作者:
Hui, J.
;
Zhao, L.
;
Lin, H.
;
Sun, Y.
;
Liu, J.
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/01/03
Evaluation of the long-term safety and effectiveness of tadalafil once daily in Chinese men with erectile dysfunction: interim results of a multicenter, randomized, open-label trial
期刊论文
2019, 卷号: 123, 期号: ,SI, 页码: 49-50
作者:
Hui, J.
;
Zhao, L.
;
Lin, H.
;
Sun, Y.
;
Liu, J.
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/01/03
Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetyicholinesterase (AChE) and Phosphodiesterase 5 (PDE5)
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 7, 页码: 1625-1636
作者:
Ni, Wei
;
Wang, Huan
;
Li, Xiaokang
;
Zheng, Xinyu
;
Wang, Manjiong
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/01/08
Multifunctional agents
AChE inhibitors
PDE5 inhibitors
Alzheimer's disease
Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 2, 页码: 328-345
作者:
Mao, Fei
;
Wang, Huan
;
Ni, Wei
;
Zheng, Xinyu
;
Wang, Manjiong
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2019/01/08
Alzheimer's disease
drug repositioning
dual-target inhibitor
AChE inhibition
PDE5 inhibition
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