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浏览/检索结果: 共6条，第1-6条 帮助 已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Rational Design, synthesis and biological evaluation of novel triazole derivatives as potent and selective PRMT5 inhibitors with antitumor activity 期刊论文 JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2019, 卷号: 33, 期号: 8, 页码: 775-785 作者:  Zhu, Kongkai;  Shao, Jingwei;  Tao, Hongrui;  Yan, Xue;  Luo, Cheng 收藏  |  浏览/下载：12/0  |  提交时间：2020/07/01 PRMT5 inhibitor  Anti-proliferative  Cellular target validation  Design and synthesis   Small ribonucleoprotein particle protein SmD3 governs the homeostasis of germline stem cells and the crosstalk between the spliceosome and ribosome signals in Drosophila 期刊论文 FASEB JOURNAL, 2019, 卷号: 33, 期号: 7, 页码: 8125-8137 作者:  Yu, Jun[1];  Luan, Xiaojin[2];  Yan, Yidan[3];  Qiao, Chen[4];  Liu, Yuanyuan[5] 收藏  |  浏览/下载：37/0  |  提交时间：2019/12/24 SmD3  RpL18  GSCs   Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3693-3699 作者:  Zhu, Kongkai;  Song, Jia-Li;  Tao, Hong-Rui;  Cheng, Zhi-Qiang;  Jiang, Cheng-Shi 收藏  |  浏览/下载：100/0  |  提交时间：2019/01/08 Pharmacophore combination  Isoquinoline  PRMT5 inhibitor  Molecular docking  Molecular dynamics simulation   Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations 期刊论文 BIOORGANIC CHEMISTRY, 2018, 卷号: 81, 页码: 289-298 作者:  Zhu, Kongkai;  Tao, Hongrui;  Song, Jia-Li;  Jin, Lu;  Zhang, Yuanyuan 收藏  |  浏览/下载：129/0  |  提交时间：2019/01/08 PRMT5 inhibitor  Arginine methylation  Virtual screening  Molecular docking  Molecular dynamics simulation   Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 14, 页码: 6289-6304 作者:  Mao, Ruifeng;  Shao, Jingwei;  Zhu, Kongkai;  Zhang, Yuanyuan;  Ding, Hong 收藏  |  浏览/下载：91/0  |  提交时间：2019/01/08 Essential Role of a Trypanosome U4-Specific Sm Core Protein in Small Nuclear Ribonucleoprotein Assembly and Splicing 期刊论文 EUKARYOTIC CELL, 2010, 卷号: 9, 期号: 3, 页码: 379-386 作者:  Jae, N;  Wang, PP;  Gu, TP;  Huhn, M;  Palfi, Z 收藏  |  浏览/下载：16/0  |  提交时间：2015/07/22