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CORC

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5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 19
作者:  Wang, Shuni;  Yang, Hong;  Su, Mingbo;  Lian, Fulin;  Cong, Zhanqing
收藏  |  浏览/下载：80/0  |  提交时间：2021/11/04
Synthesis and structure-activity relationship studies of LLY-507 analogues as SMYD2 inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 22, 页码: 5
作者:  Zhang, Bin;  Liao, Liping;  Wu, Fan;  Zhang, Fengcai;  Sun, Zhongya
收藏  |  浏览/下载：34/0  |  提交时间：2021/05/24
Lead discovery, chemical optimization, and biological evaluation studies of novel histone methyltransferase SET7 small-molecule inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 9, 页码: 10
作者:  Hou, Zeng;  Min, Wenjian;  Zhang, Rukang;  Niu, Ao;  Li, Yuanqing
收藏  |  浏览/下载：43/0  |  提交时间：2020/07/01
Amelioration of Uremic Toxin Indoxyl Sulfate-Induced Osteoblastic Calcification by SET Domain Containing Lysine Methyltransferase 7/9 Protein. 期刊论文
Nephron, 2019, 页码: 1-8
作者:  Jing Chen;  Yulu Gu;  Han Zhang;  Yichun Ning;  Nana Song
收藏  |  浏览/下载：22/0  |  提交时间：2019/12/13
Prognostic impact of SET domain-containing protein 8 and protein arginine methyltransferase 5 in patients with hepatocellular carcinoma following curative resection 期刊论文
ONCOLOGY LETTERS, 2018, 卷号: 16, 期号: 3
作者:  Lin, Zhifei;  Jia, Huliang;  Hong, Liang;  Zheng, Yahui;  Shao, Weiqin
收藏  |  浏览/下载：6/0  |  提交时间：2019/12/05
The histone methyltransferase SETD2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 24, 页码: 9188-9197
作者:  Zuo, Xiaoli;  Tong, Ming-Han;  Rong, Bowen;  Lv, Ruitu;  Lan, Fei
收藏  |  浏览/下载：42/0  |  提交时间：2019/04/28
长牡蛎免疫球蛋白超家族成员结构和功能的分析 学位论文
博士, 北京: 中国科学院大学, 2016
作者:  刘聪辉
收藏  |  浏览/下载：41/0  |  提交时间：2016/06/12
Discovery and Optimization of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Pharmacophore- and Docking-Based Virtual Screening 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2015, 卷号: 58, 期号: 20, 页码: 8166-8181
作者:  Meng, Fanwang;  Cheng, Sufang;  Ding, Hong;  Liu, Shien;  Liu, Yan
收藏  |  浏览/下载：30/0  |  提交时间：2019/01/08
Estimation of acute oral toxicity in rat using local lazy learning 期刊论文
JOURNAL OF CHEMINFORMATICS, 2014, 卷号: 6
作者:  Lu, Jing;  Peng, Jianlong;  Wang, Jinan;  Shen, Qiancheng;  Bi, Yi
收藏  |  浏览/下载：16/0  |  提交时间：2019/01/08
Epigenetic targets and drug discovery: Part 1: Histone methylation 期刊论文
Pharmacology and Therapeutics, 2014, 卷号: 143, 期号: 3, 页码: 275-294
作者:  Liu, Yanli;  Liu, Ke;  Qin, Su;  Xu, Chao;  Min, Jinrong*
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/23
Epigenetics  Histone methylation  Inhibitor  Chemical probe  Cancer  PTM  posttranslational modification  HMTs  histone methyltrans-ferases  SET  Suv39, E(z) and Trithorax  SUV39  Su(var)3-9  SUV420  histone-lysine N-methyltransferase SUV420  G9a  euchromatic histone-lysine N-methyltransferase 2  GLP  G9a-like protein 1  Wiz  widely-interspaced zinc finger-containing protein  CDYL1  chromodomain Y-like protein  ACIN1  apoptotic chromatin condensation inducer in the nucleus  SAH  S-adenosyl-l-homocysteine  l  SAM  S-adenosylmethionine  Dot1  disruptor of telomeric silencing  Dot1L  DOT1-Like protein  EZH1  Enhancer of zeste homolog 1  EZH2  Enhancer of zeste homolog 2  Hox  homeotic box  PcG  Polycomb group  PRC1  Polycomb Repressive Complex 1  PRC2  Polycomb Repressive Complex 2  DZNep  3-Deazan- eplanocin A  SMYD2  SET and MYND domain-containing protein 2  PRMT  protein arginine methyltransferases  AMI-1  arginine methyltransferase inhibitor-1  MBT  Malignant Brain Tumor  PEV  position-effect variegation  HSPC  hematopoietic stem and progenitor cells  ChIP  chromatin immunoprecipitation  PK  pharmacokinetic  

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