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科研机构
上海药物研究所 [1]
山东大学 [1]
华中师范大学 [1]
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期刊论文 [3]
发表日期
2020 [1]
2018 [1]
2014 [1]
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Synthesis and structure-activity relationship studies of LLY-507 analogues as SMYD2 inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 22, 页码: 5
作者:
Zhang, Bin
;
Liao, Liping
;
Wu, Fan
;
Zhang, Fengcai
;
Sun, Zhongya
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2021/05/24
SMYD2 inhibitors
Thermal shift assay
Structure-activity relationships
Overexpression of SET and MYND Domain-Containing Protein 2 (SMYD2) Is Associated with Tumor Progression and Poor Prognosis in Patients with Papillary Thyroid Carcinoma
期刊论文
MEDICAL SCIENCE MONITOR, 2018, 卷号: 24, 页码: 7357-7365
作者:
Xu, Wenchao
;
Chen, Fulian
;
Fei, Xiao
;
Yang, Xiaoqing
;
Lu, Xiaofei
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  |  
浏览/下载:6/0
  |  
提交时间:2019/12/11
Cell Proliferation
Prognosis
Thyroid Neoplasms
Epigenetic targets and drug discovery: Part 1: Histone methylation
期刊论文
Pharmacology and Therapeutics, 2014, 卷号: 143, 期号: 3, 页码: 275-294
作者:
Liu, Yanli
;
Liu, Ke
;
Qin, Su
;
Xu, Chao
;
Min, Jinrong*
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浏览/下载:3/0
  |  
提交时间:2019/12/23
Epigenetics
Histone methylation
Inhibitor
Chemical probe
Cancer
PTM
posttranslational modification
HMTs
histone methyltrans-ferases
SET
Suv39, E(z) and Trithorax
SUV39
Su(var)3-9
SUV420
histone-lysine N-methyltransferase SUV420
G9a
euchromatic histone-lysine N-methyltransferase 2
GLP
G9a-like protein 1
Wiz
widely-interspaced zinc finger-containing protein
CDYL1
chromodomain Y-like protein
ACIN1
apoptotic chromatin condensation inducer in the nucleus
SAH
S-adenosyl-l-homocysteine
l
SAM
S-adenosylmethionine
Dot1
disruptor of telomeric silencing
Dot1L
DOT1-Like protein
EZH1
Enhancer of zeste homolog 1
EZH2
Enhancer of zeste homolog 2
Hox
homeotic box
PcG
Polycomb group
PRC1
Polycomb Repressive Complex 1
PRC2
Polycomb Repressive Complex 2
DZNep
3-Deazan- eplanocin A
SMYD2
SET and MYND domain-containing protein 2
PRMT
protein arginine methyltransferases
AMI-1
arginine methyltransferase inhibitor-1
MBT
Malignant Brain Tumor
PEV
position-effect variegation
HSPC
hematopoietic stem and progenitor cells
ChIP
chromatin immunoprecipitation
PK
pharmacokinetic
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