transcriptional regulation  alternative splicing  pattern recognition receptors  signaling molecules  pathogens infection  teleost fish  

MDA5  Grouper  Iridovirus  RGNNV  Antiviral  

HCC  hepatocellular carcinoma  ATO  arsenic trioxide  APL  acute promyelocytic leukemia  PML  promyelocytic leukemia protein  RARα  retinoic acid receptor α  ALDH3A1  aldehyde dehydrogenase 3 family member A1  qRT-PCR  quantitative real-time reverse transcriptase polymerase chain reaction  TMA  tissue microarray  OS  overall survival  TTR  time to recurrence  DMEM  Dulbecco's modified Eagle's medium  CB7  1-[(4-fluorophenyl) sulfonyl]-2-methyl-1H-benzimidazole  siRNA  small interfering RNA  shRNA  small hairpin RNA  GFP  green fluorescent protein  MTT  3-(4,5-dimethylthiazol2-yl)-2,5-diphenyltetrazolium bromide  ChIP  chromatin immunoprecipitation  ORF  open reading frame  ROS  reactive oxygen species  DCFH-DA  2,7-dichlorfluorescein-diacetate  AFP  α-fetoprotein  ALT  alanine aminotransferase  TTP  time to progression  GO  gene ontology  NFκB  nuclear factor kappa-light-chain-enhancer of activated B cells  Bcl-2  B-cell lymphoma 2  Promyelocytic leukemia protein  Aldehyde dehydrogenase 3 family member A1  Reactive oxygen species  Tumor growth  Drug resistance  

apo  apolipoprotein  HDL  high-density lipoprotein  HNF-1α,4α  hepatocyte nuclear factor-1α,4α  LRH-1  liver receptor homolog-1  Foxa2  forkhead box A2  PAF  platelet activating factor  LXR  liver X receptor  RXR  retinoid X receptor  FXR  farnesoid X receptor  SHP  small heterodimer partner  S1P  Sphingosine-1-Phosphate  CVD  cardiovascular disease  HDL-C  HDL cholesterol  RCT  reverse cholesterol transport  MHC  major histocompatibility complex class III  TNF  tumor necrosis factor  HRP  haptoglobin-related protein  PON-I  paraoxonase-1  SNP  single nucleotide polymorphism  T1,2D  type 1,2 diabetes  RA  rheumatoid arthritis  ABCA1  ATP-binding cassette transporter A1  PPAR-γ  peroxisome proliferator-activated receptor γ  IL  interleukin  ABCG  ATP-binding cassette sub-family G  CETP  cholesteryl ester transfer protein  SR-B1  scavenger receptor class B member 1  MODY3  maturity-onset diabetes of the young type 3  MUP  major urinary protein  RBP  retinol binding protein  RAR  retinoic acid receptor  TR  thyroid hormone receptor  PI3K  phosphatidylinositol 3-kinase  DHC  dihydrocapsaicin  HRE  hormone response element  IGF-1  insulin-like growth factors  PAF-R  platelet activating factor receptor  TGF-α,β  transforming growth factor-α,β  EGF  epidermal growth factor  HGF  hepatic growth factor  VLDL  very low-density lipoprotein  LDL  low-density lipoprotein  ldlr  LDL receptor  ldlr−/−  LDL-receptor deficient  LCAT  lecithin-cholesterol acyltransferase  CE  cholesteryl ester  TC  total cholesterol  LDL-C  LDL cholesterol  VLDL-C  VLDL cholesterol  CHD  coronary heart disease  Mets  metabolic syndrome  S1PR  S1P receptor  NF-κB  nuclear factor-κB  NO  nitrogen oxide  eNOS  endothelial nitric oxide synthase  apoM-TgN mice  mice overexpressing human apoM by approximately two-fold  apoM-TgH mice  mice overexpressing human apoM by approximately ten-fold  apoM−/− mice  apoM-null mice  apoE−/−  apoE-null mice  Apolipoprotein M  Regulation  Function  

NF-KAPPA-B  RIG-I  ANTIVIRAL RESPONSE  INTERFERON-PRODUCTION  SIGNALING PATHWAYS  UBIQUITIN LIGASE  FAMILY PROTEINS  ACTIVATION  MAVS  NEMO