×
验证码:
换一张
忘记密码?
记住我
CORC
首页
科研机构
检索
知识图谱
申请加入
托管服务
登录
注册
在结果中检索
科研机构
上海药物研究所 [13]
复旦大学上海医学院 [11]
厦门大学 [7]
北京大学 [6]
上海生物化学与细胞生... [6]
大连化学物理研究所 [4]
更多...
内容类型
期刊论文 [64]
会议论文 [2]
学位论文 [2]
发表日期
2022 [2]
2021 [2]
2020 [4]
2019 [5]
2018 [9]
2017 [6]
更多...
学科主题
Oncology [2]
Science & ... [2]
Biochemist... [1]
Cell Biolo... [1]
Oncology; ... [1]
×
知识图谱
CORC
开始提交
已提交作品
待认领作品
已认领作品
未提交全文
收藏管理
QQ客服
官方微博
反馈留言
浏览/检索结果:
共68条,第1-10条
帮助
已选(
0
)
清除
条数/页:
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
排序方式:
请选择
作者升序
作者降序
题名升序
题名降序
发表日期升序
发表日期降序
提交时间升序
提交时间降序
Targeting KRAS mutant cancers: from druggable therapy to drug resistance
期刊论文
MOLECULAR CANCER, 2022, 卷号: 21
作者:
Zhu, Chunxiao
;
Guan, Xiaoqing
;
Zhang, Xinuo
;
Luan, Xin
;
Song, Zhengbo
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2022/12/23
KRAS mutations
Druggable
Resistance
Combination therapy
Utilization of genetic biomarkers testing and its associated factors in advanced colorectal cancer patients in China: a nationwide multicenter clinical epidemiological study
期刊论文
ANNALS OF TRANSLATIONAL MEDICINE, 2022
作者:
Zhang, Xi
;
Lian, Xue-Mei
;
Gu, Xiao-Fen
;
Liu, Yin
;
Feng, Chang-Yan
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2022/05/16
Colorectal cancer (CRC)
biomarker
RAS
BRAF
microsatellite instability (MSI)
Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 218, 页码: 14
作者:
Yang, Xiangbo
;
Wang, Zhijia
;
Pei, Yuan
;
Song, Ning
;
Xu, Lei
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2021/08/17
SHP2 degradation
Proteolysis targeting chimera (PROTAC)
Thalidomide-based heterobifunctional molecules
E3 ubiquitin ligase
CRBN
Whole-exome mutational landscape of neuroendocrine carcinomas of the gallbladder
期刊论文
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 卷号: 6
作者:
Liu, Fatao
;
Li, Yongsheng
;
Ying, Dongjian
;
Qiu, Shimei
;
He, Yong
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/04/26
Unveiling conformational dynamics changes of H-Ras induced by mutations based on accelerated molecular dynamics
期刊论文
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2020, 卷号: 22, 期号: 37, 页码: 21238-21250
作者:
Chen, Jianzhong
;
Wang, Wei
;
Pang, Laixue
;
Zhu, Weiliang
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/12/21
Proteomic and Phosphoproteomic Maps of Lung Squamous Cell Carcinoma From Chinese Patients
期刊论文
FRONTIERS IN ONCOLOGY, 2020, 卷号: 10, 页码: 13
作者:
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/12/24
lung squamous cell carcinoma
proteomics
phosphoproteomics
clustering
lymph node metastasis
cell cycle
Somatic variants in new candidate genes identified in focal cortical dysplasia type II
期刊论文
EPILEPSIA, 2020, 页码: 12
作者:
Zhang, Zhongbin
;
Gao, Kai
;
Liu, Qingzhu
;
Zhou, Jiapeng
;
Li, Xiyuan
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/12/10
focal cortical dysplasia type II
insulin pathway
mTOR
Ras pathway
somatic variants
EPHA2 feedback activation limits the response to PDE delta inhibition in KRAS-dependent cancer cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 2, 页码: 270-277
作者:
Chen, Yue-hong
;
Lv, Hao
;
Shen, Ning
;
Wang, Xiao-min
;
Tang, Shuai
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/01
KRAS
anticancer therapy
PDE delta
EPHA2
RAF
MEK
ERK signaling
Identification of a new inhibitor of KRAS-PDE delta interaction targeting KRAS mutant nonsmall cell lung cancer
期刊论文
INTERNATIONAL JOURNAL OF CANCER, 2019, 卷号: 145, 期号: 5, 页码: 1334-1345
作者:
Leung, Elaine Lai-Han
;
Luo, Lian Xiang
;
Li, Ying
;
Liu, Zhong-Qiu
;
Li, Lan Lan
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
Modelling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes
期刊论文
NATURE CELL BIOLOGY, 2019, 卷号: 21, 期号: 8, 页码: 1015-+
作者:
Sun, Lulu
;
Wang, Yuqing
;
Cen, Jin
;
Ma, Xiaolong
;
Cui, Lei
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/07/01
©版权所有 ©2017 CSpace - Powered by
CSpace