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上海药物研究所 [11]
厦门大学 [8]
海洋研究所 [3]
复旦大学上海医学院 [3]
山东大学 [2]
中南大学 [2]
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期刊论文 [32]
学位论文 [3]
会议论文 [2]
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2019 [3]
2018 [4]
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Repurposing antimycotic ciclopirox olamine as a promising anti-ischemic stroke agent
期刊论文
ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10, 期号: 3, 页码: 434-446
作者:
Feng, Hongxuan
;
Hu, Linghao
;
Zhu, Hongwen
;
Tao, Lingxue
;
Wu, Lei
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/01
Blood-brain barrier
Brain ischemia
Cell cycle
Inflammation
Neuroprotection
Isoflurane produces antidepressant effects inducing BDNF-TrkB signaling in CUMS mice
期刊论文
PSYCHOPHARMACOLOGY, 2019, 卷号: 236, 期号: 11, 页码: 3301-3315
作者:
Zhang, Sha-Sha
;
Tian, Yu-Hua
;
Jin, Song-Jun
;
Wang, Wen-Cheng
;
Zhao, Jing-Xin
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/09/21
Isoflurane
Rapid antidepressant activity
Chronic unpredictable mild stressed
Brain-derived neurotrophic factor
Tropomyosin receptor kinase B
Dendritic spine density
Structure‐based pharmacophore models to probe anticancer activity of inhibitors of protein kinase B‐beta (PKB β).
期刊论文
Chemical Biology & Drug Design, 2019, 卷号: Vol.93 No.3, 页码: 325-336
作者:
Akhtar, N.a
;
Jabeen, I.a
;
Jalal, N.b
;
Antilla, J.b
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/11/21
Akt
ligand–protein interactions
phosphoinositide 3‐kinase
quinoline‐type inhibitors
structure‐based pharmacophore modeling
virtual screening
Orthosilicic Acid Accelerates Bone Formation in Human Osteoblast-Like Cells Through the PI3K-Akt-mTOR Pathway
期刊论文
BIOLOGICAL TRACE ELEMENT RESEARCH, 2019, 卷号: 190, 期号: 2, 页码: 327-335
作者:
Zhou, Hongming
;
Jiao, Guangjun
;
Dong, Meng
;
Chi, Hai
;
Wang, Hongliang
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/12/11
Orthosilicic acid
Phosphatidylinositol-4
5-bisphosphate 3-kinase
(PI3K)
Protein kinase B (PKB
Akt)
Mammalian target of rapamycin
(mTOR)
Osteoporosis
Marine Bacterial Polysaccharide EPS11 Inhibits Cancer Cell Growth via Blocking Cell Adhesion and Stimulating Anoikis
期刊论文
MARINE DRUGS, 2018, 卷号: 16, 期号: 3, 页码: 18
作者:
Cao, Ruobing
;
Jin, Weihua
;
Shan, Yeqi
;
Wang, Ju
;
Liu, Ge
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2019/08/21
polysaccharide
cancer
filiform structures
beta III-tubulin
anoikis
adhesion
Novel Furocoumarin Derivatives Stimulate Melanogenesis in B16 Melanoma Cells by Up-Regulation of MITF and TYR Family via Akt/GSK3 beta/beta-Catenin Signaling Pathways
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 卷号: 19, 期号: 3, 页码: 1-19
作者:
Niu, C (Niu, Chao)[ 1 ]
;
Yin, L (Yin, Li)[ 1,2 ]
;
Aisa, HA (Aisa, Haji Akber)[ 1 ]
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2018/10/30
Vitiligo
Furocoumarin
Melanogenesis
Sar
Akt/gsk3 Beta/beta-catenin Signaling Pathways
Orthosilicic Acid Accelerates Bone Formation in Human Osteoblast-Like Cells Through the PI3K–Akt–mTOR Pathway
期刊论文
Biological Trace Element Research, 2018
作者:
Zhou H.
;
Jiao G.
;
Dong M.
;
Chi H.
;
Wang H.
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/11
Mammalian target of rapamycin (mTOR)
Orthosilicic acid
Osteoporosis
Phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)
Protein kinase B (PKB/Akt)
Statins protect diabetic myocardial microvascular endothelial cells from injury
期刊论文
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES, 2018, 卷号: 38, 期号: 4
作者:
Ge, Guanghao
;
Hou, Yuemei
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/06
Statins
Cardiac microvascular endothelial cells (CMECs)
1-integrin
Akt (protein kinase B
PKB)
SmgGDS (small GTP-binding protein dissociation stimulator)
Metformin, beyond an insulin sensitizer, targeting heart and pancreatic β cells
期刊论文
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017, 卷号: 1863, 期号: 8, 页码: 1984-1990
作者:
Yang, Xin
;
Xu, Zhipeng
;
Zhang, Chunlan
;
Cai, Zixin
;
Zhang, Jingjing*
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/12/03
A1c
glycated hemoglobin
AACE
American Association of Clinical Endocrinologists
ACC
acetyl-CoA carboxylase
ADA
American Diabetes Association
Akt/PKB
tyrosine kinase/protein kinase B
AMP
adenosine monophosphate
AMPK
adenosine monophosphate-activated protein
Ang II
angiotensin II
ATP
adenosine triphosphate
BAT
brown adipose tissue
CHOP
CEBP-homologous protein
CEBP
CCAAT enhancer binding protein
CoA
coenzyme A
DPP
Diabetes Prevention Program
EASD
European Association for the Study of Diabetes
eNOS
endothelial nitric oxide synthase
ER
endoplasmic reticulum
FDA
Food and Drug Administration
FFA
free fatty acid
FOXO1
forkhead box protein O1
G6P
glucose 6-phosphate
GDM
gestational diabetes mellitus
GIPR
glucose-dependent insulinotropic polypeptide receptor
GLP-1R
glucagon-like peptide-1 receptor
GLUT1
glucose transporter-1
GLUT4
glucose transporter type 4
GLUTs
glucose transporters
G6P
glucose 6-phosphate, glucose transporter-1
GPR40
G protein-coupled receptor 40
HbA1c
hemoglobin A1c
HGP
hepatic glucose production
HSL
hormone sensitive lipase
IL-6
interleukin 6
INS-1
insulinoma cells in rat
IR
insulin resistance
IRS-1
insulin receptor substrate 1
JNK
c-Jun. N-terminal kinase
Kir6.2
inwardly rectifying potassium/kalium channel
LDs
lipid droplets
LDL
low density lipoprotein
LV
left ventricular
MIN6 cells
mouse insulinoma cells
MAPK
mitogen-activated protein kinases
mPTP
mitochondrial permeability transition pore opening
mTOR
mammalian target of rapamycin
NADPH
nicotinamide adenine dinucleotide phosphate
NF-kappaB
nuclear factors-kappa B
NIT-1 cells
insulinoma cells
p70S6K
p70 ribosomal S6 kinase
PA
palmitic acid
NOS
NADPH oxidase
p38 MAPK
p38 mitogen-activated protein kinase
PA
palmitic acid
PCOS
polycystic ovary syndrome
PGC-1α
peroxisome proliferator-activated receptor-g coactivator-1α
PI3K
phosphatidylinositol 3-kinase
PKB
protein kinase B
PKC
protein kinase C
PPARα
peroxisome-proliferator activated receptor α
PTP
permeability transition pore
RCT
randomized controlled trial
RISK
reperfusion injury salvage kinase
ROS
reactive oxygen species
SERCA2
reticulum sarcoplasmic Ca2 +-ATPase
RISK
reperfusion injury salvage kinase
Smad3
mothers against decapentaplegic homolog 3
SRC-2
steroid receptor coactivator 2
T1DM
Type 1 diabetes mellitus
T2DM
Type 2 diabetes mellitus
TGFβ1
transforming growth factor β1
TLR4
Toll-like receptor
TNF-α
tumor necrosis factor α
TR4
testicular receptor 4
UKPDS
United Kingdom Prospective Diabetes Study
VLDL
very low density lipoprotein
Metformin
Pancreatic β Cells
Heart failure
Insulin sensitizer
NEDD4L Protein Catalyzes Ubiquitination of PIK3CA Protein and Regulates PI3K-AKT Signaling
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2016
Wang, Zixi
;
Dang, Tingting
;
Liu, Tingting
;
Chen, She
;
Li, Lin
;
Huang, Song
;
Fang, Min
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2017/12/04
Akt PKB
E3 ubiquitin ligase
phosphatidylinositide 3-kinase (PI 3-kinase)
proteasome
protein degradation
ubiquitylation (ubiquitination)
NEDD4L
PIK3CA
LIGASE NEDD4L
C2 DOMAIN
T-CELLS
CBL-B
CANCER
EXPRESSION
MUTATIONS
DEGRADATION
PROGRESSION
PROGNOSIS
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