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科研机构
上海药物研究所 [10]
北京大学 [1]
暨南大学 [1]
复旦大学上海医学院 [1]
内容类型
期刊论文 [13]
发表日期
2021 [2]
2020 [4]
2019 [2]
2018 [1]
2017 [2]
2016 [1]
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浏览/检索结果:
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Glycogen synthase kinase 3 beta inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer
期刊论文
CELL DEATH & DISEASE, 2021, 卷号: 12, 期号: 2, 页码: 18
作者:
Zhang, Ning
;
Tian, Yu-Nan
;
Zhou, Li-Na
;
Li, Meng-Zhu
;
Chen, Hua-Dong
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/05/24
Glycogen synthase kinase 3β inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer
期刊论文
Cell Death & Disease, 2021, 卷号: 12, 期号: 2, 页码: 1
作者:
Ning Zhang
;
Yu-Nan Tian
;
Li-Na Zhou
;
Meng-Zhu Li
;
Hua-Dong Chen
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2021/12/01
Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton's tyrosine kinase inhibitors
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 415-422
作者:
Lai, Meng-zhen
;
Song, Pei-ran
;
Dou, Dou
;
Diao, Yan-yan
;
Tong, Lin-jiang
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/07/01
B cell receptor
Bruton's tyrosine kinase
ibrutinib
small-molecule inhibitor
B cell malignancies
Polymerase independent repression of FoxO1 transcription by sequence-specific PARP1 binding to FoxO1 promoter
期刊论文
CELL DEATH & DISEASE, 2020, 卷号: 11, 期号: 1, 页码: 12
作者:
Tian, Yu-Nan
;
Chen, Hua-Dong
;
Tian, Chang-Qing
;
Wang, Ying-Qing
;
Miao, Ze-Hong
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2020/12/24
Novel mutations in BRCA2 intron 11 and overexpression of COX-2 and BIRC3 mediate cellular resistance to PARP inhibitors
期刊论文
AMERICAN JOURNAL OF CANCER RESEARCH, 2020, 卷号: 10, 期号: 9, 页码: 2813-+
作者:
Chen, Hua-Dong
;
Guo, Ne
;
Song, Shan-Shan
;
Chen, Chuan-Huizi
;
Miao, Ze-Hong
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/12/24
PARP inhibitors resistance
BRCA2
COX-2
BIRC3
apoptotic resistance
Novel mutations in BRCA2 intron 11 and overexpression of COX-2 and BIRC3 mediate cellular resistance to PARP inhibitors
期刊论文
AMERICAN JOURNAL OF CANCER RESEARCH, 2020, 卷号: 10, 期号: 9, 页码: 2813-+
作者:
Chen, Hua-Dong
;
Guo, Ne
;
Song, Shan-Shan
;
Chen, Chuan-Huizi
;
Miao, Ze-Hong
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2020/12/24
PARP inhibitors resistance
BRCA2
COX-2
BIRC3
apoptotic resistance
EGFR and c-MET Cooperate to Enhance Resistance to PARP Inhibitors in Hepatocellular Carcinoma
期刊论文
CANCER RESEARCH, 2019, 卷号: 79, 期号: 4
作者:
Du, Yi
;
Dong, Qiongzhu
;
Li, Hui
;
Liu, Chunxiao
;
Wei, Yongkun
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/12/05
PI3K alpha inhibitors sensitize esophageal squamous cell carcinoma to radiation by abrogating survival signals in tumor cells and tumor microenvironment
期刊论文
CANCER LETTERS, 2019, 卷号: 459, 页码: 145-155
作者:
Shi, Jia-jie
;
Xing, Hui
;
Wang, Yu-xiang
;
Zhang, Xi
;
Zhan, Qi-min
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/07/01
CYH33
Radiation
Synergism
ESCC
PI3K alpha
Acquired resistance of phosphatase and tensin homolog-deficient cells to poly(ADP-ribose) polymerase inhibitor and Ara-C mediated by 53BP1 loss and SAMHD1 overexpression
期刊论文
CANCER SCIENCE, 2018, 卷号: 109, 期号: 3, 页码: 821-831
作者:
Wang, Yu-Ting
;
Yuan, Bo
;
Chen, Hua-Dong
;
Xu, Lin
;
Tian, Yu-Nan
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/01/08
53BP1
acquired resistance
phosphatase and tensin homolog deficiency
poly(ADP-ribose) polymerase inhibitors
SAMHD1
Combining 53BP1 with BRCA1 as a biomarker to predict the sensitivity of poly(ADP-ribose) polymerase (PARP) inhibitors
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 7, 页码: 1038-1047
作者:
Yang, Zhong-min
;
Liao, Xue-mei
;
Chen, Yi
;
Shen, Yan-yan
;
Yang, Xin-ying
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/01/08
homologous recombination repair defects
breast cancer
ovarian cancer
TALEN
combined biomarker
simmiparib
olaparib
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