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CORC

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Recent progress in HIV-1 inhibitors targeting the entrance channel of HIV-1 non-nucleoside reverse transcriptase inhibitor binding pocket 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 174
作者:  Gu, Shuang-Xi;  Xiao, Ting;  Zhu, Yuan-Yuan;  Liu, Gen-Yan;  Chen, Fen-Er
收藏  |  浏览/下载：11/0  |  提交时间：2019/12/05
Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 3, 页码: 447-456
作者:  Wang, Zhao;  Yu, Zhao;  Kang, Dongwei;  Zhang, Jian;  Tian, Ye
收藏  |  浏览/下载：5/0  |  提交时间：2019/12/11
Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 4, 页码: 2083-2098
作者:  Huang, Boshi;  Chen, Wenmin;  Zhao, Tong;  Li, Zhenyu;  Jiang, Xiangyi
收藏  |  浏览/下载：15/0  |  提交时间：2019/12/11
The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to Clinic 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4851-4883
作者:  Namasivayam, Vigneshwaran;  Vanangamudi, Murugesan;  Kramer, Victor G.;  Kurup, Sonali;  Zhan, Peng
收藏  |  浏览/下载：2/0  |  提交时间：2019/12/11
Targeting the hydrophobic channel of NNIBP: discovery of novel 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs with high potency against wild-type and K103N mutant virus 期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2019, 卷号: 17, 期号: 12, 页码: 3202-3217
作者:  Zhou, Zhongxia;  Liu, Tao;  Wu, Gaochan;  Kang, Dongwei;  Fu, Zhipeng
收藏  |  浏览/下载：11/0  |  提交时间：2019/12/11
Discovery of novel indolylarylsulfones as potent HIV-1 NNRTIs via structure-guided scaffold morphing 期刊论文
European Journal of Medicinal Chemistry, 2019, 卷号: 182
作者:  Zhao T.;  Meng Q.;  Kang D.;  Ji J.;  De Clercq E.
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/11
Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs 期刊论文
Acta Pharmaceutica Sinica B, 2019
作者:  Kang D.;  Feng D.;  Ginex T.;  Zou J.;  Wei F.
收藏  |  浏览/下载：12/0  |  提交时间：2019/12/11
Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors by exploring the structure-activity relationship of solvent-exposed regions I 期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 卷号: 93, 期号: 4, 页码: 430-437
作者:  Kang, Dongwei;  Wang, Zhao;  Chen, Meng;  Feng, Da;  Wu, Gaochan
收藏  |  浏览/下载：9/0  |  提交时间：2019/12/11
Incidence and types of HIV-1 drug resistance mutation among patients failing first-line antiretroviral therapy 期刊论文
Journal of Pharmacological Sciences, 2019
作者:  Xiao-lu Luo;  Li-da Mo;  Guo-sheng Su;  Jin-ping Huang;  Jing Wu
收藏  |  浏览/下载：6/0  |  提交时间：2019/12/13
Combining New Non-Nucleoside Reverse Transcriptase Inhibitors (RTIs) with AZT Results in Strong Synergism against Multi-RTI-Resistant HIV-1 Strains 期刊论文
MOLECULES, 2018, 卷号: 23, 期号: 7
作者:  Yu, Fei;  Li, Wen;  Wang, Lili;  Dai, Yu;  Lu, Xin
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/05

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