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科研机构
上海药物研究所 [6]
湖南大学 [3]
华南理工大学 [2]
北京大学 [1]
中南大学 [1]
武汉大学 [1]
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期刊论文 [14]
会议论文 [1]
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2019 [2]
2018 [4]
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2015 [2]
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2012 [1]
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1-Phenyl-dihydrobenzoindazoles as novel colchicine site inhibitors: Structural basis and antitumor efficacy
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 177, 页码: 448-456
作者:
Jiang, Junhang
;
Zhang, Hao
;
Wang, Chongqing
;
Zhang, Qingsen
;
Fang, Shaoyu
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/07/01
Microtubule-targeting agents
Colchicine site inhibitors
Cis-trans photoisomerization
X-ray co-crystal structure
Water-soluble prodrug
Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site
期刊论文
European Journal of Medicinal Chemistry, 2019, 卷号: Vol.163, 页码: 428-442
作者:
Wenlong Li
;
Wen Shuai
;
Honghao Sun
;
Feijie Xu
;
Yi Bi
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/13
Quinoline
Indole
Microtubule
Tubulin
inhibitor
Colchicine
binding
site
Antitumor
Inhibition of kinesin family member 20B sensitizes hepatocellular carcinoma cell to microtubule-targeting agents by blocking cytokinesis
期刊论文
CANCER SCIENCE, 2018, 卷号: 109, 期号: 11, 页码: 3450-3460
作者:
Liu, Xinran
;
Zhang, Xia
;
Chen, Yuchen
;
Meng, Lijing
;
Chen, Hong
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2019/04/28
Spindle Assembly Checkpoint
Oncogenic Role
Breast-cancer
Mitotic Exit
Liver
Paclitaxel
Adenocarcinoma
Accumulation
Suppression
Resistance
Inhibition of kinesin family member 20B sensitizes hepatocellular carcinoma cell to microtubule-targeting agents by blocking cytokinesis
期刊论文
CANCER SCIENCE, 2018, 卷号: 109, 期号: 11
作者:
Liu, Xinran
;
Li, Yangkai
;
Zhang, Xia
;
Liu, Xin-Yuan
;
Peng, Anlin
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/05
cytokinesis defect
hepatocellular carcinoma
KIF20B
metaphase and telophase inhibition
microtubule-targeting agent resistance
Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site.
期刊论文
European journal of medicinal chemistry, 2018, 卷号: Vol.163, 页码: 428-442
作者:
Li Wenlong
;
Shuai Wen
;
Sun Honghao
;
Xu Feijie
;
Bi Yi
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/26
Antitumor
Colchicine
binding
site
Indole
Microtubule
Quinoline
Tubulin
inhibitor
Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site
期刊论文
European Journal of Medicinal Chemistry, 2018
作者:
Wenlong Li
;
Wen Shuai
;
Honghao Sun
;
Feijie Xu
;
Yi Bi
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/26
Quinoline
Indole
Microtubule
Tubulin
inhibitor
Colchicine
binding
site
Antitumor
A Hybrid Chalcone Combining the Trimethoxyphenyl and Isatinyl Groups Targets Multiple Oncogenic Proteins and Pathways in Hepatocellular Carcinoma Cells
期刊论文
PLOS ONE, 2016
Cao, Lili
;
Zhang, Lijun
;
Zhao, Xiang
;
Zhang, Ye
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2017/12/04
CANCER-CELLS
TUBULIN POLYMERIZATION
BIOLOGICAL EVALUATION
MUTATIONAL LANDSCAPE
MOLECULAR THERAPIES
ANTITUBULIN AGENTS
IN-VIVO
NUCLEOLIN
KINASE
IDENTIFICATION
Dual targeting of microtubule and topoisomerase II by alpha-carboline derivative YCH337 for tumor proliferation and growth inhibition
期刊论文
ONCOTARGET, 2015, 卷号: 6, 期号: 11, 页码: 8960-8973
作者:
Yi, Jun-Mei
;
Zhang, Xiao-Fei
;
Huan, Xia-Juan
;
Song, Shan-Shan
;
Wang, Wei
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
YCH337
alpha-carboline derivative
microtubule
topoisomerase II
antitumor activity
Re-expression of LKB1 in LKB1-mutant EKVX cells leads to resistance to paclitaxel through the up-regulation of MDR1 expression
期刊论文
LUNG CANCER, 2015, 卷号: 88, 页码: 131-138
作者:
Mao, Kaisheng[1,2,3,4]
;
Liu, Fakeng[1,4]
;
Liu, Xiuju[1]
;
Khuri, Fadlo R.[1]
;
Marcus, Adam I.[1]
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/04/25
Microtubule targeting agents
Paclitaxel resistance
Tumor suppressor
Promoter methylation
Multi-drug resistance
Serine/threonine kinase
Microtubule-targeting anticancer agents from marine natural substance.
期刊论文
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2014, 卷号: 14, 期号: 3, 页码: 409-417
作者:
Liu, Zhiguo
;
Xu, Pengfei
;
Wu, Tao
;
Zeng, Wenbin*
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/03
Anticancer
marine
microtubule
natural products
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