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上海药物研究所 [19]
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期刊论文 [43]
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Development of Taccalonolide AJ-Hydroxypropyl-beta-Cyclodextrin Inclusion Complexes for Treatment of Clear Cell Renal-Cell Carcinoma
期刊论文
MOLECULES, 2020, 卷号: 25, 期号: 23, 页码: 14
作者:
Han, Jing
;
Zhang, Siwang
;
Niu, Junxin
;
Zhang, Chunli
;
Dai, Weichen
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/05/24
taccalonolide AJ
microtubule stabilizer
hydroxypropyl-β
-cyclodextrin
inclusion complex
clear-cell renal-cell carcinoma
1-Phenyl-dihydrobenzoindazoles as novel colchicine site inhibitors: Structural basis and antitumor efficacy
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 177, 页码: 448-456
作者:
Jiang, Junhang
;
Zhang, Hao
;
Wang, Chongqing
;
Zhang, Qingsen
;
Fang, Shaoyu
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/07/01
Microtubule-targeting agents
Colchicine site inhibitors
Cis-trans photoisomerization
X-ray co-crystal structure
Water-soluble prodrug
Disruption of protein neddylation with MLN4924 attenuates paclitaxel-induced apoptosis and microtubule polymerization in ovarian cancer cells
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 卷号: 508, 期号: 3
作者:
Li, Siying
;
Li, Wanying
;
Xie, Min
;
Wei, Zhentong
;
Guo, Haoran
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/12/05
Neddylation
MLN4924
Paclitaxel resistance
Ovarian cancer
Discovery of Novel Quinoline–Chalcone Derivatives as Potent Antitumor Agents with Microtubule Polymerization Inhibitory Activity
期刊论文
Journal of Medicinal Chemistry, 2019, 卷号: Vol.62 No.2, 页码: 993-1013
作者:
Wenlong Li
;
Feijie Xu
;
Wen Shuai
;
Honghao Sun
;
Hong Yao
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  |  
浏览/下载:12/0
  |  
提交时间:2019/12/17
The Structure of MT189-Tubulin Complex Provides Insights into Drug Design
期刊论文
LETTERS IN DRUG DESIGN & DISCOVERY, 2019, 卷号: 16, 期号: 9, 页码: 1069-1073
作者:
Li, Zhongping
;
Ma, Lingling
;
Wu, Chengyong
;
Meng, Tao
;
Ma, Lanping
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  |  
浏览/下载:7/0
  |  
提交时间:2020/07/01
Crystal structure
tubulin
colchicine binding site
inhibitor
MT189
drug design
Synthesis, Crystal Structure and Bioactivity of Ethyl 1-((2-Bromophenyl)carbamoyl)-2-(3,4,5-trimethoxyphenyl) cyclopropanecarboxylate
期刊论文
结构化学, 2019, 卷号: 38.0, 期号: 012, 页码: 2070-2076
作者:
Jia H(贾辉)
;
Zhong HY(钟涵宇)
;
Zhang JY(张敬一)
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2021/02/02
cycolpropylamide
analogues
synthesis
bioactivity
microtubule-stabilizing
agents
Conductive Ag-Based Modification of Hydroxyapatite Microtubule Array and Its Application to Enzyme-Free Glucose Sensing
期刊论文
CHEMISTRYSELECT, 2018, 卷号: 3, 期号: 9, 页码: 2542, 2547
作者:
Jiang, Yingying
;
Liu, Haiyan
;
Qi, Xuan
;
Sun, Jun
;
Li, Mei
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2018/12/28
conductive modification
enzyme-free glucose sensing
hydroxyapatite
microtubule array
polyaniline
Disruption of protein neddylation with MLN4924 attenuates paclitaxel-induced apoptosis and microtubule polymerization in ovarian cancer cells
期刊论文
Biochemical and Biophysical Research Communications, 2018
作者:
Wanying Li
;
Xiaoling Hong
;
;
Siying Li
;
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/05
Neddylation
MLN4924
Paclitaxel resistance
Ovarian cancer
The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: Vol.293 No.24, 页码: 9461-9472
作者:
Yang, JH
;
Yan, W
;
Yu, YM
;
Wang, YX
;
Yang, T
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/02/25
microtubule
cancer prevention
cancer
natural product
tubulin
X-ray crystallography
drug resistance
Chalcone
Colchicine
Millepachine
s-trans conformation
Tubulin
PMN inhibits colorectal cancer cells through inducing mitotic arrest and p53-dependent apoptosis via the inhibition of tubulin polymerization
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 卷号: 499, 期号: 4, 页码: 927-933
作者:
Wu, Xingkang
;
Shen, Yuemao
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  |  
浏览/下载:6/0
  |  
提交时间:2019/12/11
PMN
Colorectal cancer
Mitotic arrest
Microtubule
Apoptosis
p53
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