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上海药物研究所 [20]
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期刊论文 [66]
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Decreased mitochondrial DNA copy number in nerve cells and the hippocampus during nicotine exposure is mediated by autophagy
期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2021, 卷号: 226
作者:
Wang, Hongjuan
;
Chen, Huan
;
Han, Shulei
;
Fu, Yaning
;
Tian, Yushan
收藏
  |  
浏览/下载:115/0
  |  
提交时间:2021/11/15
nicotine
mtDNA copy number
autophagy
mitochondrial abnormalities
Imatinib inhibits the malignancy of hepatocellular carcinoma by suppressing autophagy
期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2021, 卷号: 906, 页码: 8
作者:
Xiao, Meng-Chao
;
Qian, Hui
;
Huang, Chen-Kai
;
Zheng, Bai-Nan
;
Yan, Fang-Zhi
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  |  
浏览/下载:50/0
  |  
提交时间:2021/11/04
Imatinib
Autophagy
Hepatocarcinoma
Sorafenib
Synergetic effect
ULK1 inhibitor induces spindle microtubule disorganization and inhibits phosphorylation of Ser10 of histone H3
期刊论文
FEBS OPEN BIO, 2020, 卷号: 10
作者:
Ji, Xinmiao
;
Zhang, Xin
;
Li, Zhiyuan
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  |  
浏览/下载:22/0
  |  
提交时间:2020/12/07
autophagy
mitosis
MRT68921
polyploidy
SBI‐
0206965
ULK1 inhibitor
SHR-A1403, a novel c-mesenchymal-epithelial transition factor (c-Met) antibody-drug conjugate, overcomes AZD9291 resistance in non-small cell lung cancer cells overexpressing c-Met
期刊论文
CANCER SCIENCE, 2019, 页码: 11
作者:
Tong, Mengya
;
Gao, Mingzhao
;
Xu, Yongping
;
Fu, Li
;
Li, Yun
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
AZD9291
c-Met ADC
c-Met overexpression
resistance
SHR-A1403
1-Phenyl-dihydrobenzoindazoles as novel colchicine site inhibitors: Structural basis and antitumor efficacy
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 177, 页码: 448-456
作者:
Jiang, Junhang
;
Zhang, Hao
;
Wang, Chongqing
;
Zhang, Qingsen
;
Fang, Shaoyu
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/07/01
Microtubule-targeting agents
Colchicine site inhibitors
Cis-trans photoisomerization
X-ray co-crystal structure
Water-soluble prodrug
SHR-A1403, a novel c-Met antibody-drug conjugate, exerts encouraging anti-tumor activity in c-Met-overexpressing models
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 7, 页码: 971-979
作者:
Yang, Chang-yong
;
Wang, Lei
;
Sun, Xing
;
Tang, Mi
;
Quan, Hai-tian
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
SHR-A1403
c-Met ADC
anti-tumor
patient-derived xenograft (PDX)
molecular mechanisms
The Novel Nature Microtubule Inhibitor Ivalin Induces G2/M Arrest and Apoptosis in Human Hepatocellular Carcinoma SMMC-7721 Cells In Vitro
期刊论文
MEDICINA-LITHUANIA, 2019, 卷号: 55, 期号: 8
作者:
Liu, Fangyuan
;
Lin, Shiqi
;
Zhang, Caiyun
;
Ma, Jiahui
;
Han, Zhuo
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/11
Ivalin
carpesium divaricatum
HCC
microtubule
cell cycle arrest
apoptosis
Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site
期刊论文
European Journal of Medicinal Chemistry, 2019, 卷号: Vol.163, 页码: 428-442
作者:
Wenlong Li
;
Wen Shuai
;
Honghao Sun
;
Feijie Xu
;
Yi Bi
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/13
Quinoline
Indole
Microtubule
Tubulin
inhibitor
Colchicine
binding
site
Antitumor
The Structure of MT189-Tubulin Complex Provides Insights into Drug Design
期刊论文
LETTERS IN DRUG DESIGN & DISCOVERY, 2019, 卷号: 16, 期号: 9, 页码: 1069-1073
作者:
Li, Zhongping
;
Ma, Lingling
;
Wu, Chengyong
;
Meng, Tao
;
Ma, Lanping
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/07/01
Crystal structure
tubulin
colchicine binding site
inhibitor
MT189
drug design
Synthesis, Crystal Structure and Bioactivity of Ethyl 1-((2-Bromophenyl)carbamoyl)-2-(3,4,5-trimethoxyphenyl) cyclopropanecarboxylate
期刊论文
结构化学, 2019, 卷号: 38.0, 期号: 012, 页码: 2070-2076
作者:
Jia H(贾辉)
;
Zhong HY(钟涵宇)
;
Zhang JY(张敬一)
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2021/02/02
cycolpropylamide
analogues
synthesis
bioactivity
microtubule-stabilizing
agents
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