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CORC

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Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 216, 页码: 20
作者:  Gao, Dingding;  Jin, Nan;  Fu, Yixian;  Zhu, Yueyue;  Wang, Yujie
收藏  |  浏览/下载：43/0  |  提交时间：2021/06/11
3-Deoxy-2 beta,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells 期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 12, 页码: 1578-1586
作者:  Shan, Hui;  Yao, Sheng;  Ye, Yang;  Yu, Qiang
收藏  |  浏览/下载：9/0  |  提交时间：2020/07/01
Novel-targeted therapy for hematological malignancies with JAK and HDAC dual inhibitors 期刊论文
FUTURE MEDICINAL CHEMISTRY, 2019, 卷号: 11, 期号: 15, 页码: 1849-1852
作者:  Liang, Xuewu;  Liu, Hong;  Zhang, Yingjie
收藏  |  浏览/下载：14/0  |  提交时间：2020/07/01
Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 8, 页码: 3898-3923
作者:  Liang, Xuewu;  Zang, Jie;  Li, Xiaoyang;  Tang, Shuai;  Huang, Min
收藏  |  浏览/下载：18/0  |  提交时间：2020/07/01
Discovery of novel selective Janus kinase 2 (JAK2) inhibitors bearing a 1H-pyrazolo[3,4-d]pyrimidin-4-amino scaffold 期刊论文
2019, 卷号: 27, 期号: 8, 页码: 1562-1576
作者:  Yin, Yuan;  Chen, Cheng-Juan;  Yu, Ru-Nan;  Shu, Lei;  Zhang, Tian-Tai
收藏  |  浏览/下载：3/0  |  提交时间：2020/01/03
3deoxy216dihydroxynagilactoneeanaturalcompoundfrompodocarpusnagipreferentiallyinhibitsjak2stat3signalingbyallostericallyinteractingwiththeregulatorydomainofjak2andinducesapoptosisofcancercells 期刊论文
actapharmacologicasinica, 2019, 卷号: 40, 期号: 12, 页码: 1578
作者:  Shan Hui;  Yao Sheng;  Ye Yang;  Yu Qiang
收藏  |  浏览/下载：12/0  |  提交时间：2020/07/01
3-Deoxy-2β,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/ STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells 期刊论文
中国药理学报:英文版, 2019, 卷号: 40.0, 期号: 012, 页码: 1578
作者:  Hui Shan;  Sheng Yao;  Yang Ye;  Qiang Yu
收藏  |  浏览/下载：16/0  |  提交时间：2020/12/24
A new xanthatin analogue 1 beta-hydroxyl-5 alpha-chloro-8-epi-xanthatin induces apoptosis through ROS-mediated ERK/p38 MAPK activation and JAK2/STAT3 inhibition in human hepatocellular carcinoma 期刊论文
BIOCHIMIE, 2018, 卷号: 152, 期号: 2018, 页码: 43-52
作者:  Fang, Xin-Yi;  Zhang, Hai;  Zhao, Lin;  Tan, Shuai;  Ren, Qing-Cuo
收藏  |  浏览/下载：14/0  |  提交时间：2020/12/24
Discovery of a series of dihydroquinoxalin-2(1H)-ones as selective BET inhibitors from a dual PLK1-BRD4 inhibitor 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 137, 页码: 176-195
作者:  Hu, Jianping;  Wang, Yingqing;  Li, Yanlian;  Xu, Lin;  Cao, Danyan
收藏  |  浏览/下载：32/0  |  提交时间：2019/01/08
Identification of 4-(2-furanyl)pyrimidin-2-amines as Janus kinase 2 inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 卷号: 25, 页码: 75-83
作者:  Wang, Yazhou;  Huang, Wei;  Xin, Minhang;  Chen, Pan;  Gui, Li
收藏  |  浏览/下载：4/0  |  提交时间：2019/11/26

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