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上海药物研究所 [3]
大连化学物理研究所 [2]
湖南大学 [2]
北京大学 [1]
西安交通大学 [1]
内容类型
期刊论文 [9]
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2019 [1]
2018 [3]
2012 [1]
2011 [3]
2007 [1]
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Mechanisms of poor oral bioavailability of flavonoid Morin in rats: From physicochemical to biopharmaceutical evaluations
期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 卷号: Vol.128, 页码: 290-298
作者:
Li, Jianbo
;
Yang, Yang
;
Ning, Erjuan
;
Peng, Youmei
;
Zhang, Jinjie
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/17
Morin
Oral absorption mechanism
Intestinal first-pass metabolism
Physicochemical
Biopharmaceutical
A Biomimetic Human Gut-on-a-Chip for Modeling Drug Metabolism in Intestine
期刊论文
ARTIFICIAL ORGANS, 2018, 卷号: 42, 期号: 12, 页码: 1196-1205
作者:
Guo, Yaqiong
;
Li, Zhongyu
;
Su, Wentao
;
Wang, Li
;
Zhu, Yujuan
收藏
  |  
浏览/下载:63/0
  |  
提交时间:2019/06/20
Gut-on-a-chip
Caco-2
Intestinal metabolism
Biomimetic
Drug metabolism
A biomimetic human gut-on-a-chip for modeling drug metabolism in intestine
期刊论文
Artificial organs, 2018, 卷号: 42, 期号: 12, 页码: 1196-1205
作者:
Guo, Yaqiong
;
Li, Zhongyu
;
Su, Wentao
;
Wang, Li
;
Zhu, Yujuan
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2019/05/08
Gut-on-a-chip
Caco-2
Intestinal metabolism
Biomimetic
Drug metabolism
Mechanisms of poor oral bioavailability of flavonoid Morin in rats: From physicochemical to biopharmaceutical evaluations.
期刊论文
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2018
作者:
Li Jianbo
;
Yang Yang
;
Ning Erjuan
;
Peng Youmei
;
Zhang Jinjie
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/26
Biopharmaceutical
Intestinal
first-pass
metabolism
Morin
Oral
absorption
mechanism
Physicochemical
Intestinal Absorption and First-Pass Metabolism of Polyphenol Compounds in Rat and Their Transport Dynamics in Caco-2 Cells
期刊论文
PLOS ONE, 2012, 卷号: 7, 期号: [db:dc_citation_issue]
作者:
Teng, Zenghui
;
Yuan, Chengjun
;
Zhang, Feng
;
Huan, Menglei
;
Cao, Weidong
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/10
An Examination of the Potential Effect of Lipids on the First-Pass Metabolism of the Lipophilic Drug Anethol Trithione
期刊论文
JOURNAL OF PHARMACEUTICAL SCIENCES, 2011, 卷号: 100, 期号: 11, 页码: 5048-5058
作者:
Yu, Hong-Zhen
;
Han, Si-Fei
;
Li, Ping
;
Zhu, Chun-Liu
;
Zhang, Xin-Xin
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
anethol trithione
medium chain triglycerides
first-pass metabolism
hepatic metabolism
nonlinear pharmacokinetics
dose proportionality
drug metabolizing enzymes
inhibition
formulation
lipids
Absorption and Disposition of Scutellarin in Rats: A Pharmacokinetic Explanation for the High Exposure of Its Isomeric Metabolite
期刊论文
DRUG METABOLISM AND DISPOSITION, 2011, 卷号: 39, 期号: 11, 页码: 2034-2044
作者:
Gao, Chunying
;
Chen, Xiaoyan
;
Zhong, Dafang
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/01/08
Contribution of Carboxylesterase in Hamster to the Intestinal First-Pass Loss and Low Bioavailability of Ethyl Piperate, an Effective Lipid-Lowering Drug Candidate
期刊论文
DRUG METABOLISM AND DISPOSITION, 2011, 卷号: 39, 期号: 5, 页码: 796-802
作者:
Lu, Youli
;
Bao, Narisu
;
Borjihan, Gereltu
;
Ma, Yanling
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
ADME evaluation in drug discovery. 7. Prediction of oral absorption by correlation and classification
期刊论文
journal of chemical information and modeling, 2007
Hou, Tingjun
;
Wang, Junmei
;
Zhang, Wei
;
Xu, Xiaojie
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2015/11/12
HUMAN INTESTINAL-ABSORPTION
POLAR SURFACE-AREA
CACO-2 CELL-LINE
MOLECULAR CONNECTIVITY
GENETIC ALGORITHMS
PERMEABILITY
HUMANS
QSAR
DESCRIPTORS
PERMEATION
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