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Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 216, 页码: 20
作者:
Gao, Dingding
;
Jin, Nan
;
Fu, Yixian
;
Zhu, Yueyue
;
Wang, Yujie
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/06/11
STAT3 signaling pathway
Benzothiazole
Rational design
Antitumor activity
Molecular docking
3-Deoxy-2 beta,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 12, 页码: 1578-1586
作者:
Shan, Hui
;
Yao, Sheng
;
Ye, Yang
;
Yu, Qiang
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/07/01
JAK/STAT
3-deoxy-2 beta,16-dihydroxynagilactone E
tyrosine kinase inhibitor
allosteric inhibitor
cancer
2-ethoxystypandrone, a novel small-molecule stat3 signaling inhibitor from polygonum cuspidatum, inhibits cell growth and induces apoptosis of hcc cells and hcc cancer stem cells
期刊论文
Bmc complementary and alternative medicine, 2019, 卷号: 19, 页码: 13
作者:
Li, Wuguo
;
Zhang, Qing
;
Chen, Kaotan
;
Sima, Zhenhua
;
Liu, Jingli
收藏
  |  
浏览/下载:88/0
  |  
提交时间:2019/05/08
Polygonum cuspidatum
2-ethoxystypandrone
Hepatocellular carcinoma
Cancer stem cells
Stat3 signaling pathway
Cancer stemness inhibitor
2-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells
期刊论文
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2019, 卷号: 19, 页码: 13
作者:
Li, Wuguo
;
Zhang, Qing
;
Chen, Kaotan
;
Sima, Zhenhua
;
Liu, Jingli
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2020/07/01
Polygonum cuspidatum
2-Ethoxystypandrone
Hepatocellular carcinoma
Cancer stem cells
STAT3 signaling pathway
Cancer stemness inhibitor
3deoxy216dihydroxynagilactoneeanaturalcompoundfrompodocarpusnagipreferentiallyinhibitsjak2stat3signalingbyallostericallyinteractingwiththeregulatorydomainofjak2andinducesapoptosisofcancercells
期刊论文
actapharmacologicasinica, 2019, 卷号: 40, 期号: 12, 页码: 1578
作者:
Shan Hui
;
Yao Sheng
;
Ye Yang
;
Yu Qiang
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/07/01
JAK/STAT
3-deoxy-2β
16-dihydroxynagilactone E
tyrosine kinase inhibitor
allosteric inhibitor
cancer
3-Deoxy-2β,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/ STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells
期刊论文
中国药理学报:英文版, 2019, 卷号: 40.0, 期号: 012, 页码: 1578
作者:
Hui Shan
;
Sheng Yao
;
Yang Ye
;
Qiang Yu
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/12/24
JAK/STAT
3-deoxy-2β,16-dihydroxynagilactone
E
tyrosine
kinase
inhibitor
allosteric
inhibitor
cancer
Parthenolide Inhibits STAT3 Signaling by Covalently Targeting Janus Kinases
期刊论文
MOLECULES, 2018, 卷号: 23, 期号: 6
作者:
Liu, Man
;
Xiao, Chengqian
;
Sun, Mingwei
;
Tan, Minjia
;
Hu, Lihong
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
parthenolide
covalent inhibitor
cell death
JAK/STAT3 signaling
石斑鱼干扰素信号通路关键基因STAT1a和MAVS在病毒感染过程中的作用机制
学位论文
: 南海海洋研究所, 2018
作者:
张竞成
收藏
  |  
浏览/下载:76/0
  |  
提交时间:2019/09/11
石斑鱼,EcSTAT1a,EcMAVS,病毒复制
Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity
期刊论文
JOURNAL OF LIPID RESEARCH, 2017, 卷号: 58, 期号: 11, 页码: 2102-2113
作者:
Sun, Shuhong
;
Wang, Ran
;
Song, Jianwen
;
Guan, Ming
;
Li, Na
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2018/04/25
Glycoprotein 130
Autotaxin
Adipocyte
Insulin Sensitivity
Obesity
Dihydrocelastrol inhibits multiple myeloma cell proliferation and promotes apoptosis through ERK1/2 and IL-6/STAT3 pathways in vitro and in vivo
期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2017, 卷号: 49, 期号: 5, 页码: 420-427
作者:
Hu, Liangning
;
Wu, Huiqun
;
Li, Bo
;
Song, Dongliang
;
Yang, Guang
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
dihydrocelastrol
multiple myeloma
apoptosis
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