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浏览/检索结果: 共11条，第1-10条 帮助 已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Efficient precise knockin with a double cut HDR donor after CRISPR/Cas9-mediated double-stranded DNA cleavage 期刊论文 2017, 卷号: 18 作者:  Zhang, Jian-Ping;  Li, Xiao-Lan;  Li, Guo-Hua;  Chen, Wanqiu;  Arakaki, Cameron 收藏  |  浏览/下载：4/0  |  提交时间：2020/01/04 CRISPR  Genome editing  Knockin  Homology-directed repair (HDR)  Non-homologous end joining (NHEJ)  Donor design  293 T  Human induced pluripotent stem cells   An alternative strategy for targeted gene replacement in plants using a dual-sgRNA/Cas9 design 期刊论文 SCIENTIFIC REPORTS, 2016, 卷号: 6, 页码: - 作者:  Zhao, Yongping;  Zhang, Congsheng;  Liu, Wenwen;  Gao, Wei;  Liu, Changlin 收藏  |  浏览/下载：8/0  |  提交时间：2016/12/05 CRISPR/Cas9: A powerful tool for crop genome editing 期刊论文 The Crop Journal, 2016, 卷号: 4, 期号: 2, 页码: 75-82 作者:  Song Gaoyuan;  Jia Meiling;  Chen Kai;  Kong Xingchen;  Khattak Bushra 收藏  |  浏览/下载：5/0  |  提交时间：2017/04/20 CRISPR/Cas9  Double-strand break  Genome editing  TALENs  ZFNs   CRISPR/Cas9: A powerful tool for crop genome editing 期刊论文 The Crop Journal, 2016, 卷号: 4, 期号: 2, 页码: 75-82 作者:  Song Gaoyuan;  Jia Meiling;  Chen Kai;  Kong Xingchen;  Khattak Bushra 收藏  |  浏览/下载：5/0  |  提交时间：2017/10/22 CRISPR/Cas9  Double-strand break  Genome editing  TALENs  ZFNs   Precise Genome Modification via Sequence-Specific Nucleases-Mediated Gene Targeting for Crop Improvement 期刊论文 FRONTIERS IN PLANT SCIENCE, 2016, 卷号: 7, 页码: - 作者:  Sun, Yongwei;  Li, Jingying;  Xia, Lanqin 收藏  |  浏览/下载：5/0  |  提交时间：2017/05/03 clustered regularly interspersed short palindromic repeats (CRISPR)/Cas9  crops  double strand breaks (DSBs)  gene targeting (GT)  homology-directed repair (HDR)  sequence-specific nucleases (SSNs)  transcription activator-like effector nucleases (TALENs)  zinc finger nucleases (ZFNs)   The application of genome editing in studying hearing loss 期刊论文 Hearing Research, 2015, 卷号: 327, 期号: Volume 327, 页码: 102-108 作者:  Zou, Bing;  Mittal, Rahul;  Grati, M'hamed;  Lu, Zhongmin;  Shu, Yilai 收藏  |  浏览/下载：9/0  |  提交时间：2019/12/03 AAV  Adeno-associated virus  ARHL  age-related hearing loss  Cas9  CRISPR-associated nuclease 9  CRISPR  clustered, regularly interspaced, short palindromic repeat  crRNA  CRISPR RNA  dCas9  defective Cas9  DSBs  double-strand breaks  gRNA  guide RNA  HDR  homology-directed-repair  HL  hearing loss  HR  homologous recombination  NHEJ  non-homologous-end-joining  PAM  protospacer-adjacent motif  RVD  repeat-variable di-residue  siRNA  small interfering RNA  TALENs  transcriptional activator-like effector nucleases  TALEs  transcription activator-like effectors  tracrRNA  trans-acting crRNA  ZFNs  Zinc finger nucleases   Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells 期刊论文 细胞研究英文版, 2015 Wu, Yuxuan; Zhou, Hai; Fan, Xiaoying; Zhang, Ying; Zhang, Man; Wang, Yinghua; Xie, Zhenfei; Bai, Meizhu; Yin, Qi; Liang, Dan; Tang, Wei; Liao, Jiaoyang; Zhou, Chikai; Liu, Wujuan; Zhu, Ping; Guo, Hongshan; Pan, Hong; Wu, Chunlian; Shi, Huijuan; Wu, Ligang; Tang, Fuchou; Li, Jinsong 收藏  |  浏览/下载：4/0  |  提交时间：2015/11/13 CRISPR-Cas9  spermatogonial stem cell  gene therapy  GERMLINE TRANSMISSION  IN-VITRO  MUSCULAR-DYSTROPHY  CAS9 NUCLEASE  MODIFIED MICE  SELF-RENEWAL  C-KIT  GENOME  GENERATION  CULTURE   Creating a monomeric endonuclease TALE-I-SceI with high specificity and low genotoxicity in human cells 期刊论文 核酸研究, 2015 Lin, Jianfei; Chen, He; Luo, Ling; Lai, Yongrong; Xie, Wei; Kee, Kehkooi 收藏  |  浏览/下载：3/0  |  提交时间：2015/11/13 ZINC-FINGER NUCLEASES  HISTONE H2AX PHOSPHORYLATION  GENE-THERAPY  MAMMALIAN-CELLS  CAS9  ARCHITECTURE  SYSTEMS  REPAIR  BREAKS   Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells 期刊论文 CELL RESEARCH, 2015, 卷号: 25, 期号: 1, 页码: 67-79 作者:  Wu, YX;  Zhou, H;  Fan, XY;  Zhang, Y;  Zhang, M 收藏  |  浏览/下载：44/0  |  提交时间：2015/07/22 CRISPR-Cas9  spermatogonial stem cell  gene therapy   Various applications of TALEN- and CRISPR/Cas9-mediated homologous recombination to modify the Drosophila genome 期刊论文 2014 Yu, Zhongsheng; Chen, Hanqing; Liu, Jiyong; Zhang, Hongtao; Yan, Yan; Zhu, Nannan; Guo, Yawen; Yang, Bo; Chang, Yan; Dai, Fei; Liang, Xuehong; Chen, Yixu; Shen, Yan; Deng, Wu-Min; Chen, Jianming; Zhang, Bo; Li, Changqing; Jiao, Renjie 收藏  |  浏览/下载：3/0  |  提交时间：2015/11/16 Drosophila  TALEN  CRISPR/Cas9  Homologous recombination  Targeted genomic modification  ZINC-FINGER NUCLEASES  ONE-STEP GENERATION  TARGETED MUTAGENESIS  C. ELEGANS  EFFICIENT  RNA  TRANSCRIPTION  MELANOGASTER  ZEBRAFISH  STRATEGY