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山东大学 [6]
上海药物研究所 [4]
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大连化学物理研究所 [1]
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期刊论文 [11]
会议论文 [1]
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Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H, 3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 17, 页码: 3836-3845
作者:
Gao, Ping
;
Cheng, Xiqiang
;
Sun, Lin
;
Song, Shu
;
Alvarez, Mar
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/11
HIV-1
RNase H
Integrase
Dual inhibitors
Update on Recent Developments in Small Molecular HIV-1 RNase H Inhibitors (2013-2016): Opportunities and Challenges
期刊论文
CURRENT MEDICINAL CHEMISTRY, 2018, 卷号: 25, 期号: 14, 页码: 1682-1702
作者:
Wang, Xueshun
;
Gao, Ping
;
Menendez-Arias, Luis
;
Liu, Xinyong
;
Zhan, Peng
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/11
AIDS
HIV-1
RNase H inhibitors
dual inhibitors
drug design
SAR
antiviral
metalloenzyme
5-Hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 155, 页码: 714-724
作者:
Sun, Lin
;
Gao, Ping
;
Dong, Guanyu
;
Zhang, Xujie
;
Cheng, Xiqiang
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/11
HAART
HIV-1 dual inhibitors
HIV-1 IN
RNase H
5-hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives
Privileged
structure
Discovery of novel 3-hydroxypicolinamides as selective inhibitors of HIV-1 integrase-LEDGF/p75 interaction
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 125, 页码: 1051-1063
作者:
Zhang, Feng-Hua
;
Debnath, Bikash
;
Xu, Zhong-Liang
;
Yang, Liu-Meng
;
Song, Li-Rui
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  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
HIV-1 integrase
Allosteric inhibitor
LEDGF/p75
Dimerization
3-Hydroxypicolinamide
Discovery of novel 3-hydroxypicolinamides as selective inhibitors of HIV-1 integrase-LEDGF/p75 interaction
期刊论文
European Journal of Medicinal Chemistry, 2017, 卷号: 125, 期号: X, 页码: 1051-1063
作者:
Zhang FH
;
Debnath B
;
Zheng YT
;
Neamati N[*]
;
Long YQ[*]
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  |  
浏览/下载:72/0
  |  
提交时间:2016/11/07
3-Hydroxypicolinamide
Allosteric inhibitor
Dimerization
HIV-1 integrase
LEDGF/p75
Probing Origin of Binding Difference of inhibitors to MDM2 and MDMX by Polarizable Molecular Dynamics Simulation and QM/MM-GBSA Calculation
期刊论文
SCIENTIFIC REPORTS, 2015, 卷号: 5
作者:
Chen, Jianzhong
;
Wang, Jinan
;
Zhang, Qinggang
;
Chen, Kaixian
;
Zhu, Weiliang
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  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
Novel piperidinylamino-diarylpyrimidine derivatives with dual structural conformations as potent HIV-1 non-nucleoside reverse transcriptase inhibitors
期刊论文
Bioorganic and Medicinal Chemistry Letters, 2013, 卷号: 23, 期号: 24, 页码: 6593-6597
作者:
Chen,X.
;
Liu,X.
;
Meng,Q.
;
Wang,D.
;
Liu,H.
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  |  
浏览/下载:9/0
  |  
提交时间:2019/12/23
DAPY
Dual conformations
HIV-1 NNRTIs
Molecular hybridization
Piperidin-4-yl-aminopyrimidines
Computational Studies of Difference in Binding Modes of Peptide and Non-Peptide Inhibitors to MDM2/MDMX Based on Molecular Dynamics Simulations
期刊论文
international journal of molecular sciences, 2012, 卷号: 13, 期号: 2, 页码: 2176-2195
作者:
Chen, Jianzhong
;
Zhang, Dinglin
;
Zhang, Yuxin
;
Li, Guohui
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2015/11/13
p53-MDM2/MDMX interaction
molecular dynamics simulation
binding free energy
alanine scanning
The Development of HEPT-Type HIV Non-Nucleoside Reverse Transcriptase Inhibitors and Its Implications for DABO Family
期刊论文
CURRENT PHARMACEUTICAL DESIGN, 2012, 卷号: 18, 期号: 27, 页码: 4165-4186
作者:
Chen, Wenmin
;
Zhan, Peng
;
Wu, Jingde
;
Li, Zhenyu
;
Liu, Xinyong
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/23
HIV-1
HEPT
NNRTI
DABO
structure-activity relationship
drug design
dual inhibitor
pyrimidinedione
Highly Potent and Dual-acting Pyrimidinedione Inhibitors of HIV-1 Possess a High Genetic Barrier to Resistance
会议论文
22nd International Conference on Antiviral Research, MAY 03-07, 2009
作者:
Liu, Xinyong
;
Zhan, Peng
;
Pannecouque, Christophe
;
De Clercq, Erik
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  |  
浏览/下载:3/0
  |  
提交时间:2019/12/31
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