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CORC

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Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 4, 页码: 2083-2098
作者:  Huang, Boshi;  Chen, Wenmin;  Zhao, Tong;  Li, Zhenyu;  Jiang, Xiangyi
收藏  |  浏览/下载：15/0  |  提交时间：2019/12/11
First discovery of a potential carbonate prodrug of NNRTI drug candidate RDEA427 with submicromolar inhibitory activity against HIV-1 K103N/Y181C double mutant strain 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 8, 页码: 1348-1351
作者:  Huang, Boshi;  Liu, Xinhao;  Tian, Ye;  Kang, Dongwei;  Zhou, Zhongxia
收藏  |  浏览/下载：2/0  |  提交时间：2019/12/11
Discovery of Novel Diarylpyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the "NNRTI Adjacent" Binding Site 期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 9, 期号: 4, 页码: 334-338
作者:  Huo, Zhipeng;  Zhang, Heng;  Kang, Dongwei;  Zhou, Zhongxia;  Wu, Gaochan
收藏  |  浏览/下载：5/0  |  提交时间：2019/12/11
Design, synthesis and biological evaluation of substituted (+)-SG-l derivatives as novel anti-HIV agents 期刊论文
2018, 卷号: 28, 期号: 10, 页码: 1699-1703
作者:  Liu, Xiaoyu;  Chen, Panpan;  Li, Xiaoyu;  Ba, Mingyu;  Jiao, Xiaozhen
收藏  |  浏览/下载：2/0  |  提交时间：2020/01/03
基于逆转录酶结构和耐药突变的新型非核苷类逆转录酶抑制剂研究进展 期刊论文
国际药学研究杂志, 2018, 期号: 2, 页码: 81-87
作者:  zhengyt@mail.kiz.ac.cn;  唐成润;  杨柳萌;  郑永唐
收藏  |  浏览/下载：18/0  |  提交时间：2018/09/06
Novel fused pyrimidine and isoquinoline derivatives as potent HIV-1 NNRTIs: a patent evaluation of WO2016105532A1, WO2016105534A1 and WO2016105564A1 期刊论文
EXPERT OPINION ON THERAPEUTIC PATENTS, 2017, 卷号: 27, 期号: 4, 页码: 383-391
作者:  Kang, Dongwei;  Huo, Zhipeng;  Wu, Gaochan;  Xu, Jiabao;  Zhan, Peng
收藏  |  浏览/下载：13/0  |  提交时间：2019/12/12
Synthesis, biological evaluation and molecular docking study of N-(2-methoxyphenyl)-6-((4-nitrophenyl)sulfonyl)benzamide derivatives as potent HIV-1 Vif antagonists 期刊论文
European Journal of Medicinal Chemistry, 2017, 卷号: 129, 期号: X, 页码: 310-324
作者:  Zhou M;  Luo RH;  Chen H;  Zhang RH;  Shi JY
收藏  |  浏览/下载：119/0  |  提交时间：2017/02/28
Lindenane sesquiterpenoid dimers from Chloranthus japonicus inhibit HIV-1 and HCV replication 期刊论文
FITOTERAPIA, 2016, 卷号: 115, 期号: 1, 页码: 64-68
作者:  Yan, Haan;  Ba, Ming -Yu;  Li, Xu-Hong;  Guo, Jia-Mei;  Qin, Xu-Jie
收藏  |  浏览/下载：42/0  |  提交时间：2017/02/14
Novel diarylpyrimidines and diaryltriazines as potent HIV-1 NNRTIs with dramatically improved solubility: a patent evaluation of US20140378443A1 期刊论文
EXPERT OPINION ON THERAPEUTIC PATENTS, 2016, 卷号: 26, 期号: 2, 页码: 281-289
作者:  Huang, Boshi;  Kang, Dongwei;  Yang, Jiapei;  Zhan, Peng;  Liu, Xinyong
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/16
Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives targeting the entrance channel of NNRTI binding pocket 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 109, 页码: 294-304
作者:  Yang, Jiapei;  Chen, Wenmin;  Kang, Dongwei;  Lu, Xueyi;  Li, Xiao
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/17

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