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科研机构
上海药物研究所 [7]
厦门大学 [4]
武汉病毒研究所 [2]
兰州大学 [1]
复旦大学上海医学院 [1]
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期刊论文 [14]
学位论文 [1]
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2019 [2]
2018 [2]
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pharmacolo... [1]
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Treatment of Chronic Hepatitis B Virus Infection Using Small Molecule Modulators of Nucleocapsid Assembly: Recent Advances and Perspectives
期刊论文
ACS INFECTIOUS DISEASES, 2019, 卷号: 5, 期号: 5, 页码: 713-724
作者:
Yang, Li
;
Liu, Feifei
;
Tong, Xiankun
;
Hoffmann, Daniel
;
Zuo, Jianping
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
hepatitis B virus
HBV core protein
HBcAg
capsid assembly
capsid assembly modulators (CAMs)
antiviral therapy
clinical trials
Naturally occurring core protein mutations compensate for the reduced replication fitness of a lamivudine-resistant HBV isolate
期刊论文
ANTIVIRAL RESEARCH, 2019, 卷号: 165
作者:
Zhang, Yongmei
;
Zhang, Hu
;
Zhang, Junjie
;
Zhang, Jiming
;
Guo, Haitao
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/12/05
Hepatitis B virus
Drug resistance
Replication fitness
Capsid assembly
Mechanisms and effects on hbv replication of the interaction between hbv core protein and cellular filamin b
期刊论文
Virologica sinica, 2018, 卷号: 33, 期号: 2, 页码: 162-172
作者:
Li, Yilin
;
Sun, Yishuang
;
Sun, Fuyun
;
Hua, Rong
;
Li, Chenlin
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2019/05/08
Filamin b
Core
Hbv replication
Small Molecule Inhibitors of Hepatitis B Virus Nucleocapsid Assembly: A New Approach to Treat Chronic HBV Infection
期刊论文
CURRENT MEDICINAL CHEMISTRY, 2018, 卷号: 25, 期号: 7, 页码: 802-813
作者:
Yang, Li
;
Lu, Mengji
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
Hepatitis B virus
core protein
capsid assembly
capsid assembly modulator
misassembly
antiviral therapy
Exploring the binding mechanism of Heteroaryldihydropyrimidines and Hepatitis B Virus capsid combined 3D-QSAR and molecular dynamics
期刊论文
ANTIVIRAL RESEARCH, 2017, 卷号: 137, 页码: 151-164
作者:
Tu, J
;
Li, JJ
;
Shan, ZJ
;
Zhai, HL
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2017/05/08
Heteroaryldihydropyrimidines (HAPs)
HBV capsid protein
Quantitative structure-activity relationship
Molecular dynamics
Binding free energy
Effect of a hepatitis B virus inhibitor, NZ-4, on capsid formation
期刊论文
ANTIVIRAL RESEARCH, 2016, 卷号: 125, 页码: 25-33
作者:
Yang, Li
;
Wang, Ya-Juan
;
Chen, Hai Jun
;
Shi, Li-Ping
;
Tong, Xian-Kun
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2019/01/08
Anti-hepatitis B virus compound
Capsid formation
pgRNA packaging
Arg-rich domain I
Faster-migrating capsid
A Novel Pyridazinone Derivative Inhibits Hepatitis B Virus Replication by Inducing Genome-Free Capsid Formation
期刊论文
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 卷号: 59, 期号: 11, 页码: 7061-7072
作者:
Wang, Ya-Juan
;
Lu, Dong
;
Xu, Yi-Bin
;
Xing, Wei-Qiang
;
Tong, Xian-Kun
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation
期刊论文
ACTA PHARMACOLOGICA SINICA, 2014, 卷号: 35, 期号: 3, 页码: 410-418
作者:
Yang, Li
;
Shi, Li-ping
;
Chen, Hai-jun
;
Tong, Xian-kun
;
Wang, Gui-feng
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
hepatitis B
virus replication
capsid assembly
pregenomic RNA
non-nucleoside compound
isothiafludine
lamivudine
adefovir
entecavir
lsothlafliudilne, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation
期刊论文
Acta Pharmacologica Sinica, 2014, 卷号: 35, 期号: 3, 页码: 410
作者:
Yang Li
;
Shi Liping
;
Chen Haijun
;
Tong Xiankun
;
Wang Guifeng
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/12/24
hepatitis B
virus replication
capsid assembly
pregenomic RNA
non-nucleoside compound
isothiafludine
lamivudine
adefovir
entecavir
lsothlafliudilneanovelnonnucleosidecompoundinhibitshepatitisbvirusreplicationthroughblockingpregenomicrnaencapsidation
期刊论文
actapharmacologicasinica, 2014, 卷号: 35, 期号: 3, 页码: 410
作者:
Yang Li
;
Shi Liping
;
Chen Haijun
;
Tong Xiankun
;
Wang Guifeng
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/07/01
hepatitis B
virus replication
capsid assembly
pregenomic RNA
non-nucleoside compound
isothiafludine
lamivudine
adefovir
entecavir
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