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Intestinal farnesoid X receptor signaling controls hepatic fatty acid oxidation 期刊论文
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2022, 卷号: 1867, 期号: 2, 页码: 13
作者:  Lu, Dasheng;  Liu, Yameng;  Luo, Yuhong;  Zhao, Jie;  Feng, Chao
收藏  |  浏览/下载:49/0  |  提交时间:2022/01/18
Discovery of novel ketoxime ether derivatives with potent FXR agonistic activity, oral effectiveness and high liver/blood ratio 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 43, 页码: 13
作者:  Tang, Xuehang;  Ning, Mengmeng;  Ye, Yangliang;  Gu, Yipei;  Yan, Hongyi
收藏  |  浏览/下载:49/0  |  提交时间:2021/11/04
miR-552-3p modulates transcriptional activities of FXR and LXR to ameliorate hepatic glycolipid metabolism disorder 期刊论文
JOURNAL OF HEPATOLOGY, 2021, 卷号: 74, 期号: 1, 页码: 8-19
作者:  Fan, Lei;  Lai, Rongtao;  Ma, Ningning;  Dong, Yunxia;  Li, Yu
收藏  |  浏览/下载:41/0  |  提交时间:2021/05/24
Discovery and Optimization of Non-bile Acid FXR Agonists as Preclinical Candidates for the Treatment of Nonalcoholic Steatohepatitis 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 21, 页码: 12748-12772
作者:  Li, Junyou;  Liu, Mengqi;  Li, Yazhou;  Sun, Dan-dan;  Shu, Zhihao
收藏  |  浏览/下载:22/0  |  提交时间:2021/05/24
The protective effect and mechanism of the FXR agonist obeticholic acid via targeting gut microbiota in non-alcoholic fatty liver disease 期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2019, 卷号: 13
作者:  Zhang, Dan-Ying;  Zhu, Lin;  Liu, Hai-Ning;  Tseng, Yu-Jen;  Weng, Shu-Qiang
收藏  |  浏览/下载:25/0  |  提交时间:2019/12/05
Beneficial effect of resveratrol on α‑naphthyl isothiocyanate‑induced cholestasis via regulation of the FXR pathway 期刊论文
Molecular medicine reports, 2018, 卷号: 17, 期号: 1, 页码: 1863-1872
作者:  Ding, Lili;  Zhang, Binfeng;  Li, Jinmei;  Yang, Li;  Wang, Zhengtao
收藏  |  浏览/下载:28/0  |  提交时间:2019/01/08
FXR Primes the Liver for Intestinal FGF15 Signaling by Transient Induction of beta-Klotho 期刊论文
MOLECULAR ENDOCRINOLOGY, 2016, 卷号: 30, 期号: 1, 页码: 92-103
作者:  Fu, Ting;  Kim, Young-Chae;  Byun, Sangwon;  Kim, Dong-Hyun;  Seok, Sunmi
收藏  |  浏览/下载:23/0  |  提交时间:2019/01/08
Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor alpha (FXR alpha) in Stabilizing the Homodimerization of the Receptor 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 卷号: 290, 期号: 32, 页码: 19888-19899
作者:  Xu, Xing;  Xu, Xin;  Liu, Peng;  Zhu, Zhi-yuan;  Chen, Jing
收藏  |  浏览/下载:10/0  |  提交时间:2019/01/08
Design, Synthesis, and Biological Evaluation of Novel Nonsteroidal FarnesoidX Receptor (FXR) Antagonists: Molecular Basis of FXR Antagonism 期刊论文
CHEMMEDCHEM, 2015, 卷号: 10, 期号: 7, 页码: 1184-1199
作者:  Huang, Huang;  Si, Pei;  Wang, Lei;  Xu, Yong;  Xu, Xin
收藏  |  浏览/下载:16/0  |  提交时间:2019/01/08
Discovery of New Non-Steroidal Farnesoid X Receptor Modulators Through 3D Shape Similarity Search and Structure-Based Virtual Screening 期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2015, 卷号: 85, 期号: 4, 页码: 481-487
作者:  Wang, Lei;  Si, Pei;  Sheng, Yayun;  Chen, Yingjie;  Wan, Ping
收藏  |  浏览/下载:20/0  |  提交时间:2019/01/08


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