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科研机构
北京大学 [5]
内容类型
期刊论文 [5]
发表日期
2012 [1]
2011 [3]
2010 [1]
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Ethaselen: a potent mammalian thioredoxin reductase 1 inhibitor and novel organoselenium anticancer agent
期刊论文
free radical biology and medicine, 2012
Wang, Lihui
;
Yang, Zhiyu
;
Fu, Jianing
;
Yin, Hanwei
;
Xiong, Kun
;
Tan, Qiang
;
Jin, Hongwei
;
Li, Jing
;
Wang, Tianyu
;
Tang, Wanchen
;
Yin, Jin
;
Cai, Gaoxiong
;
Liu, Mi
;
Kehr, Sebastian
;
Becker, Katja
;
Zeng, Huihui
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2015/11/10
Mammalian thioredoxin reductase 1
Thioredoxin
Ethaselen
Enzyme inhibitor
Selenium compound
Anticancer agent
Free radicals
GLUTATHIONE-REDUCTASE
CANCER-THERAPY
MOLECULAR-MECHANISM
GROWTH-INHIBITION
ANTITUMOR QUINOLS
ESCHERICHIA-COLI
CARCINOMA-CELLS
LUNG-CARCINOMA
HUMAN PLACENTA
IN-VITRO
Selenium-containing thioredoxin reductase inhibitor ethaselen sensitizes non-small cell lung cancer to radiotherapy
期刊论文
anti cancer drugs, 2011
Wang, Lei
;
Fu, Jia-ning
;
Wang, Jing-yu
;
Jin, Cun-jing
;
Ren, Xiao-yuan
;
Tan, Qiang
;
Li, Jing
;
Yin, Han-wei
;
Xiong, Kun
;
Wang, Tian-yu
;
Liu, Xin-min
;
Zeng, Hui-hui
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2015/11/13
ethaselen
NF-kappa B
non-small cell lung cancer
radiosensitizer
thioredoxin reductase inhibitor
IONIZING-RADIATION
KAPPA-B
APOPTOSIS
LINES
CARBOPLATIN
THERAPY
GROWTH
EXPRESSION
MECHANISM
Novel mechanism of ethaselen in poorly differentiated colorectal RKO cell growth inhibition: Simultaneous regulation of TrxR transcription, expression and enzyme activity
期刊论文
differentiation, 2011
Yin, Hanwei
;
Li, Jing
;
Xiong, Kun
;
Wang, Lihui
;
Wang, Tianyu
;
Tan, Qiang
;
Fu, Jianing
;
Ren, Xiaoyuan
;
Zeng, Huihui
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2015/11/10
Thioredoxin reductase
Ethaselen
RKO cell
LoVo cell
Poorly differentiated
Wnt/beta-catenin
THIOREDOXIN REDUCTASE INHIBITOR
CANCER STEM-CELLS
BETA-CATENIN
PROGENITOR CELLS
TGF-BETA
IN-VITRO
APOPTOSIS
PROTEIN
GENE
LINES
Thioredxin reductase inhibitor ethaselen increases the drug sensitivity of the colon cancer cell line LoVo towards cisplatin via regulation of G1 phase and reversal of G2/M phase arrest
期刊论文
investigational new drugs, 2011
Fu, Jia-ning
;
Li, Jing
;
Tan, Qiang
;
Yin, Han-wei
;
Xiong, Kun
;
Wang, Tian-yu
;
Ren, Xiao-yuan
;
Zeng, Hui-hui
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2015/11/10
Ethaselen
Cisplatin
Combination index
Cell cycle regulation
LoVo
DNA-DAMAGE
QUANTITATIVE-ANALYSIS
INDUCED CYTOTOXICITY
POSSIBLE INVOLVEMENT
CYCLE
APOPTOSIS
P53
MECHANISM
GROWTH
UCN-01
Augmented antitumor effects of combination therapy of cisplatin with ethaselen as a novel thioredoxin reductase inhibitor on human A549 cell in vivo
期刊论文
investigational new drugs, 2010
Tan, Qiang
;
Li, Jing
;
Yin, Han-wei
;
Wang, Li-hui
;
Tang, Wan-chen
;
Zhao, Fang
;
Liu, Xin-min
;
Zeng, Hui-hui
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2015/11/10
Ethaselen
Thioredoxin reductase inhibitor
Cisplatin
Non-small cell lung cancer
Combination chemotherapy
Synergistic effect
LUNG-CANCER CELLS
MAMMALIAN THIOREDOXIN
POSSIBLE INVOLVEMENT
CYCLE ARREST
APOPTOSIS
CARCINOMA
DESIGN
GROWTH
LINES
CIS-DIAMMINEDICHLOROPLATINUM(II)
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