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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers
期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:
Lu, Xuxiu
;
Yu, Rilei
;
Li, Zhen
;
Yang, Mengke
;
Dai, Jiajia
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/04/07
Acquired resistance
Cancer
NSCLC
JC-010a
SHP2
A Phase 2 Study of Befotertinib in Patients with EGFR T790M Mutated NSCLC after Prior EGFR TKIs
期刊论文
JOURNAL OF THORACIC ONCOLOGY, 2022, 卷号: 17
作者:
Lu, S.
;
Zhang, Y.
;
Zhang, G.
;
Zhou, J.
;
Cang, S.
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/12/23
third-generation EGFR-TKI
befotertinib
T790M
Impact of clinical and molecular features on efficacy and outcome of patients with non-small cell lung cancer receiving second-line osimertinib
期刊论文
BMC CANCER, 2022, 卷号: 22
作者:
Jin, Ying
;
Lin, Chen
;
Shi, Xun
;
He, Qiong
;
Yan, Junrong
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/12/23
Clinical and molecular features
Efficacy and outcome
EGFR T790M mutation
Non-small-cell lung cancer
Osimertinib
Clinical outcomes of lung adenocarcinoma patients harboring uncommon epidermal growth factor receptor (EGFR) mutations treated with EGFR-tyrosine kinase inhibitors (TKIs)
期刊论文
ANNALS OF PALLIATIVE MEDICINE, 2021
作者:
Si, Jinfei
;
Gu, Xiaodong
;
Wang, Wenxian
;
Ying, Shenpeng
;
Song, Zhengbo
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2022/02/14
Epidermal growth factor receptor (EGFR)
uncommon mutation
compound mutation
double uncommon mutation
lung adenocarcinoma (lung AC)
LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo
期刊论文
CANCER SCIENCE, 2021, 页码: 12
作者:
Liu, Yingqiang
;
Lai, Mengzhen
;
Li, Shan
;
Wang, Yanan
;
Feng, Fang
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2022/01/18
C797S
epidermal growth factor receptor
fourth-generation EGFR TKI
non-small cell lung cancer
osimertinib resistance
Effect of autoinduction and food on the pharmacokinetics of furmonertinib and its active metabolite characterized by a population pharmacokinetic model
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Zou, Hui-xi
;
Zhang, Yu-feng
;
Zhong, Da-fang
;
Jiang, Yong
;
Liu, Fei
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2022/01/04
furmonertinib
autoinduction
food effect
alkaline phosphatase
body weight
pharmacokinetics
modeling and simulation
NSCLC
The correlation between the abundance of EGFR T790M mutation and osimertinib response in advanced non-small cell lung cancer
期刊论文
TRANSLATIONAL CANCER RESEARCH, 2021, 卷号: 10
作者:
Pan, Guoqiang
;
Chen, Kaiyan
;
Yu, Xiaoqing
;
Sheng, Jiamin
;
Fan, Yun
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/11/01
Non-small cell lung cancer (NSCLC)
T790M abundance
droplet digital PCR (ddPCR)
next generation sequencing (NGS)
osimertinib
Metabolic disposition of the EGFR covalent inhibitor furmonertinib in humans
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Meng, Jian
;
Zhang, Hua
;
Bao, Jing-jing
;
Chen, Zhen-dong
;
Liu, Xiao-yun
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2021/06/11
metabolism
mass balance
distribution
covalent binding
furmonertinib
Metabolic disposition of the EGFR covalent inhibitor furmonertinib in humans
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Meng, Jian
;
Zhang, Hua
;
Bao, Jing-jing
;
Chen, Zhen-dong
;
Liu, Xiao-yun
收藏
  |  
浏览/下载:70/0
  |  
提交时间:2021/06/11
metabolism
mass balance
distribution
covalent binding
furmonertinib
Third-generation EGFR inhibitor HS-10296 in combination with famitinib, a multi-targeted tyrosine kinase inhibitor, exerts synergistic antitumor effects through enhanced inhibition of downstream signaling in EGFR-mutant non-small cell lung cancer cells
期刊论文
THORACIC CANCER, 2021, 页码: 9
作者:
Zhang, Mi
;
Quan, Haitian
;
Fu, Li
;
Li, Yun
;
Fu, Haoyu
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2021/05/24
EGFR‐
mutant non‐
small cell lung cancer
famitinib
HS‐
10296
multi‐
targeted tyrosine kinase inhibitor
third‐
generation EGFR inhibitor
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