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New monoamine antidepressant, hypidone hydrochloride (YL-0919), enhances the excitability of medial prefrontal cortex in mice via a neural disinhibition mechanism
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Zhang, Yong-Mei
;
Ye, Lu-Yu
;
Li, Tian-Yu
;
Guo, Fan
;
Guo, Fei
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/01/04
YL-0919
medial prefrontal cortex
GABAergic neurons
5-HT1A receptor
GAD67-GFP transgenic mice
disinhibition
fluoxetine
electrophysiological recording
Insights into agonist-elicited activation of the human glucose-dependent insulinotropic polypeptide receptor
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2021, 卷号: 192, 页码: 16
作者:
Yuliantie, Elita
;
van der Velden, Wijnand J. C.
;
Labroska, Viktorija
;
Dai, Antao
;
Zhao, Fenghui
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  |  
浏览/下载:44/0
  |  
提交时间:2021/11/04
Glucose-dependent insulinotropic polypeptide receptor
G protein-coupled receptor
GPCR structure-function relationship
ERK
cAMP
Arrestin
Microfluidic paper-based chips in rapid detection: Current status, challenges, and perspectives
期刊论文
TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2021, 卷号: 143, 页码: 15
作者:
Qin, Xiaoxiao
;
Liu, Jiajing
;
Zhang, Zhong
;
Li, Jinhua
;
Yuan, Li
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  |  
浏览/下载:15/0
  |  
提交时间:2022/08/10
Microfluidic paper-based chips
Rapid detection
Food safety
Portable device
Pathogen
Novel selective kappa agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Wei, Yuan-yuan
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浏览/下载:40/0
  |  
提交时间:2021/11/04
kappa-opioid receptor agonist
4,5-expoxymorphinan
antinociception
conditioned place aversion
sedation
U50,488H
morphine
Nor-BNI
beta-FNA
Different conformational responses of the beta(2)-adrenergic receptor-Gs complex upon binding of the partial agonist salbutamol or the full agonist isoprenaline
期刊论文
NATIONAL SCIENCE REVIEW, 2021, 卷号: 8
作者:
Yang, Fan
;
Ling, Shenglong
;
Zhou, Yingxin
;
Zhang, Yanan
;
Lv, Pei
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  |  
浏览/下载:43/0
  |  
提交时间:2021/11/01
cryo-EM structure
G protein-coupled receptor (GPCR)
partial and full agonists
conformational change
desensitization
Signaling profiles in HEK 293T cells co-expressing GLP-1 and GIP receptors
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 8
作者:
Wang, Yu-zhe
;
Yang, De-hua
;
Wang, Ming-wei
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浏览/下载:22/0
  |  
提交时间:2021/11/04
glucagon-like peptide-1 receptor
glucose-dependent insulinotropic peptide receptor
peptide 19
LY3298176
heteromerization
type 2 diabetes
Hypothalamic Melanocortin and Mesencephalic Dopamine Systems Regulate Reward-related Behaviors in Food Intake and Drug Use
期刊论文
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2021, 卷号: 48, 期号: 5, 页码: 541-549
作者:
Liu Ying
;
Liu Chao
;
Lin Qing-Hua
;
Zhang Jian-Jun
;
Du Wen-Jie
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  |  
浏览/下载:55/0
  |  
提交时间:2021/08/07
motivated behavior
drug addiction
dopamine
melanocortin system
proopiomelanocortin neuron
agouti-related protein neuron
The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity
期刊论文
JOURNAL OF INNATE IMMUNITY, 2021, 页码: 15
作者:
Martensson, Jonas
;
Sundqvist, Martina
;
Manandhar, Asmita
;
Leremias, Loukas
;
Zhang, Linjie
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  |  
浏览/下载:42/0
  |  
提交时间:2021/05/24
Neutrophils
G protein-coupled receptors
Cross-talk
Nicotine adenine dinucleotide phosphate oxidase
Insights into the molecular mechanism of positive cooperativity between partial agonist MK-8666 and full allosteric agonist AP8 of hGPR40 by Gaussian accelerated molecular dynamics (GaMD) simulations
期刊论文
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021, 卷号: 19, 页码: 3978-3989
作者:
An, Xiaoli
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  |  
浏览/下载:13/0
  |  
提交时间:2021/12/08
hGPR40
Positive binding cooperativity
Partial agonist
AgoPAM
Gaussian accelerated molecular dynamics simulation
Evaluation of biased agonism mediated by dual agonists of the GLP-1 and glucagon receptors
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 180, 页码: 16
作者:
Darbalaei, Sanaz
;
Yuliantie, Elita
;
Dai, Antao
;
Chang, Rulue
;
Zhao, Peishen
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  |  
浏览/下载:19/0
  |  
提交时间:2020/12/21
G protein-coupled receptor
Glucagon-like peptide-1 receptor
Glucagon receptor
Biased agonism
Unimolecular dual agonist
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