×
验证码:
换一张
忘记密码?
记住我
CORC
首页
科研机构
检索
知识图谱
申请加入
托管服务
登录
注册
在结果中检索
科研机构
上海药物研究所 [49]
厦门大学 [31]
复旦大学上海医学院 [18]
中南大学 [16]
山东大学 [11]
昆明植物研究所 [9]
更多...
内容类型
期刊论文 [158]
学位论文 [22]
会议论文 [11]
专利 [3]
发表日期
2021 [4]
2020 [1]
2019 [14]
2018 [14]
2017 [20]
2016 [16]
更多...
学科主题
Biochemist... [4]
Neuroscien... [2]
Cell Biolo... [1]
Chemistry [1]
Multidisci... [1]
Pharmacolo... [1]
更多...
×
知识图谱
CORC
开始提交
已提交作品
待认领作品
已认领作品
未提交全文
收藏管理
QQ客服
官方微博
反馈留言
浏览/检索结果:
共194条,第1-10条
帮助
已选(
0
)
清除
条数/页:
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
排序方式:
请选择
作者升序
作者降序
题名升序
题名降序
发表日期升序
发表日期降序
提交时间升序
提交时间降序
Traceable Nano-Biohybrid Complexes by One-Step Synthesis as CRISPR-Chem Vectors for Neurodegenerative Diseases Synergistic Treatment
期刊论文
ADVANCED MATERIALS, 2021, 页码: 10
作者:
Shen, Jie
;
Lu, Zhiguo
;
Wang, Jianze
;
Hao, Qiulian
;
Ji, Weihong
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2021/08/31
CRISPR
Cas9
CRISPR‐
chem vectors
neurodegenerative diseases synergistic treatment
one‐
step synthesis
traceable nano‐
biohybrid complexes
Increasing the Sampling Efficiency of Protein Conformational Change by Combining a Modified Replica Exchange Molecular Dynamics and Normal Mode Analysis
期刊论文
JOURNAL OF CHEMICAL THEORY AND COMPUTATION, 2021, 卷号: 17, 期号: 1, 页码: 13-28
作者:
Peng, Cheng
;
Wang, Jinan
;
Shi, Yulong
;
Xu, Zhijian
;
Zhu, Weiliang
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2021/05/24
Ameliorating Ribosylation-Induced Amyloid-beta Pathology by Berberine via Inhibiting mTOR/p70S6K Signaling
期刊论文
JOURNAL OF ALZHEIMERS DISEASE, 2021, 卷号: 79, 期号: 2, 页码: 833-844
作者:
Wang, Yang-Yang
;
Yan, Qian
;
Huang, Zhen-Ting
;
Zou, Qian
;
Li, Jing
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/03/29
AGEs
Alzheimer's disease
amyloid-beta
autophagy
berberine
mTOR
Novel Plasma miRNAs as Biomarkers and Therapeutic Targets of Alzheimer's Disease at the Prodromal Stage
期刊论文
JOURNAL OF ALZHEIMERS DISEASE, 2021, 卷号: 83, 期号: 2, 页码: 779-790
作者:
He, Haining
;
Liu, An
;
Zhang, Wei
;
Yang, Huanqing
;
Zhang, Minmin
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/11/04
Alzheimer's disease
biomarkers
microRNAs
mild cognitive impairment
Neuroprotective Effects of Triterpenoids from Camellia japonica against Amyloid β-Induced Neuronal Damage
期刊论文
Journal of Natural Products, 2020, 卷号: 83, 期号: 7, 页码: 2076–2086
作者:
Hyo-Moon Cho
;
Thi-Kim-Quy Ha
;
Thi-Phuong Doan
;
Basanta Dhodary
;
Jin-Pyo An
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/11/16
Molecular Mechanism of Binding Selectivity of Inhibitors toward BACE1 and BACE2 Revealed by Multiple Short Molecular Dynamics Simulations and Free-Energy Predictions
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2019, 卷号: 10, 期号: 10, 页码: 4303-4318
作者:
Chen, Jianzhong
;
Wang, Jinan
;
Yin, Baohua
;
Pang, Laixue
;
Wang, Wei
收藏
  |  
浏览/下载:114/0
  |  
提交时间:2020/07/01
beta-amyloid cleaving enzyme
binding selectivity
MSMD
hierarchical clustering analysis
MM-GBSA
Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungus Aspergillus terreus Thom
期刊论文
PHYTOCHEMISTRY, 2019, 卷号: 165, 页码: 8
作者:
Qi, Changxing
;
Zhou, Qun
;
Gao, Weixi
;
Liu, Mengting
;
Chen, Chunmei
收藏
  |  
浏览/下载:82/0
  |  
提交时间:2019/10/14
Aspergillus terreus Thom
endophytic fungus
3,5-Dimethylorsellinic acid-based meroterpenoid
Adducts
Alzheimer's disease
D3Pockets: A Method and Web Server for Systematic Analysis of Protein Pocket Dynamics
期刊论文
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2019, 卷号: 59, 期号: 8, 页码: 3353-3358
作者:
Chen, Zhaoqiang
;
Zhang, Xinben
;
Peng, Cheng
;
Wang, Jinan
;
Xu, Zhijian
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/07/01
Structure-Based Survey of the Binding Modes of BACE1 Inhibitors
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2019, 卷号: 10, 期号: 2, 页码: 880-889
作者:
Hu, Hangchen
;
Chen, Zhaoqiang
;
Xu, Xiang
;
Xuo, Yechun
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/07/01
BACE1
Alzheimer's disease
inhibitor
ligand binding mode
subsite
substructure
Inhibition of sphingomyelin synthase 1 ameliorates alzheimer-like pathology in APP/PS1 transgenic mice through promoting lysosomal degradation of BACE1
期刊论文
EXPERIMENTAL NEUROLOGY, 2019, 卷号: 311
作者:
Lu, Mei-Hong
;
Ji, Wen-Li
;
Xu, De-En
;
Yao, Pei-Pei
;
Zhao, Xiu-Yun
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/12/04
BACE1
Sphingomyelin
Amyloid-beta
Lysosomal degradation
Alzheimer's disease
Lipids
©版权所有 ©2017 CSpace - Powered by
CSpace